Age-Related Changes in Vancomycin Protein Binding: Is It Time to Take It Seriously?
Jessica Gadsby,
Lucy Stachow,
Hussain Mulla
Abstract:Background:
Vancomycin (VAN) protein binding in plasma is influenced by illness and age; hence, doses titrated according to total concentrations are fraught. In this study, model-estimated free VAN concentrations (EFVC) were compared with assumed free VAN concentrations (AFVC) in neonates, children, and adults in the intensive care unit and those on dialysis.
Methods:
Patient cohorts were identified from the hospital database. Demographics, clinical cha… Show more
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