Age-related changes in ultrastructure of mitochondria. Effect of SkQ1

Bakeeva, L. E.

doi:10.1134/s0006297915120068

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…Nowadays, SkQ1 is being used in many fields: inflammation [122,123], wound healing [122,124], tumor growth suppression [125], Alzheimer's disease [126], fertility [127], aging [128,129], immunoregulation [130], ischemia [131] and mitochondrial diseases [132,133] among others. All of them are related with mitochondrial function and ROS homeostasis.…”

Section: Plastoquinone and Skq1mentioning

confidence: 99%

“…Idebenone LHON Approved for patients' treatment [46][47][48] Friedreich ataxia Patients' treatment [27,[49][50][51] Pulmonary fibrosis Tested in vivo [64] Dementia Patients' treatment [65] MELAS Patients' treatment [66] Glaucoma Patients' treatment [67] Mitoquinone Heart failure Tested in vivo [76] Hypertension Tested in vivo [77] Diabetic kidney disease Tested in vivo [78] Alcoholic fatty liver disease Tested in vivo [79] Hepatitis C Patients' treatment [80] Parkinson's disease Patients' treatment [81,82] Alzheimer's disease Tested in vivo [83,84] Huntington's disease Tested in vivo [85] Amyotrophic lateral sclerosis Tested in vivo [86] Traumatic brain injury Tested in vivo [87] Decylubiquinone LHON In vitro studies [102] Cancer Tested in vivo [103][104][105] Hypertension Tested in vivo [106] SkQ1 Inflammation Tested in vivo [122,123] Wound healing Tested in vivo [122,124] Tumor growth suppression In vitro studies [125] Alzheimer's disease Tested in vivo [126] Fertility Tested in vivo [127] Aging Tested in vivo [128,129] Immunoregulation Tested in vivo [130] Ischemia Tested in vivo [131] Dry eye treatment Patients' treatment…”

Section: Coenzyme Q 10 Analogue Medical Applications Level Of Study Rmentioning

confidence: 99%

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Coenzyme Q10 Analogues: Benefits and Challenges for Therapeutics

et al. 2021

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Coenzyme Q10 (CoQ10 or ubiquinone) is a mobile proton and electron carrier of the mitochondrial respiratory chain with antioxidant properties widely used as an antiaging health supplement and to relieve the symptoms of many pathological conditions associated with mitochondrial dysfunction. Even though the hegemony of CoQ10 in the context of antioxidant-based treatments is undeniable, the future primacy of this quinone is hindered by the promising features of its numerous analogues. Despite the unimpeachable performance of CoQ10 therapies, problems associated with their administration and intraorganismal delivery has led clinicians and scientists to search for alternative derivative molecules. Over the past few years, a wide variety of CoQ10 analogues with improved properties have been developed. These analogues conserve the antioxidant features of CoQ10 but present upgraded characteristics such as water solubility or enhanced mitochondrial accumulation. Moreover, recent studies have proven that some of these analogues might even outperform CoQ10 in the treatment of certain specific diseases. The aim of this review is to provide detailed information about these Coenzyme Q10 analogues, as well as their functionality and medical applications.

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