2014
DOI: 10.18632/aging.100669 View full text |Buy / Rent full text
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Abstract: Cardiac tissue macrophages (cTMs) are abundant in the murine heart but the extent to which the cTM phenotype changes with age is unknown. This study characterizes aging-dependent phenotypic changes in cTM subsets. Using the Cx3cr1GFP/+ mouse reporter line where GFP marks cTMs, and the tissue macrophage marker Mrc1, we show that two major cardiac tissue macrophage subsets, Mrc1−GFPhi and Mrc1+GFPhi cTMs, are present in the young (<10 week old) mouse heart, and a third subset, Mrc1+GFPlo, comprises ~50% of total… Show more

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“…4B-4C). These findings are also consistent with the reported observations that show downregulation of immune response genes (45). Interestingly, we found a lesser number of neutrophils in TLR2-KO hearts (Fig.…”
Section: Tlr2 Deficient Hearts Harbour Reduced Residual Macrophages Asupporting
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“…4B-4C). These findings are also consistent with the reported observations that show downregulation of immune response genes (45). Interestingly, we found a lesser number of neutrophils in TLR2-KO hearts (Fig.…”
Section: Tlr2 Deficient Hearts Harbour Reduced Residual Macrophages Asupporting
“…Age-dependent decline in the number of macrophages has been observed in aging hearts (35,43). Therefore, we tested whether TLR2-KO hearts showed any changes in the population of macrophages in the heart.…”
Section: Tlr2 Deficient Hearts Harbour Reduced Residual Macrophages Amentioning
“…In the heart, we and others have recently shown that cTMs are also proliferative (Fig. 2), dividing throughout life (Epelman et al, 2014;Heidt et al, 2014;Pinto et al, 2014).…”
Section: Embryonic and Adult Origins Of Cardiac Tissue Macrophagesmentioning
“…Such monocyte-derived cardiac macrophages have been reported to hold higher proinflammatory potential, compared with their embryonic counterparts (5). Furthermore, Pinto et al (57) reported that a profibrotic resident macrophage subset (defined as CX3CR1 low CD206 + ) arises in the myocardium of 30-wk-old animals. In the current study, we also expand these observations and report shifts in the myocardial myeloid compartment at advanced ages (in animals aged 12 to 15 mo old).…”
Section: Discussionmentioning