Age-Related Changes in Tissue and Plasma Zinc Levels: Modulation by Exogenously Administered Melatonin

Öztürk, Güler; Akbulut, K. Gonca; Afrasyap, Lale

doi:10.1080/03610730802271922

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…Our findings do not preclude an alteration of the micronutrient content in the bone matrix; the addition of trace amounts of zinc [19], [20], [21], [22] or strontium [23], [24], [25] to bone matrix can improve fracture resistance and strength without affecting overall weight or total mineral content. Melatonin has been shown to affect absorption of micronutrients, including ions [26], [27] such as zinc [28], [29].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Melatonin on the Physical Properties of Bones and Egg Shells in the Laying Hen

et al. 2013

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Laying hens often experience unbalanced calcium utilization which can cause deficiencies in bone and egg mineralization. Because melatonin has been shown to affect bone mineralization in other animals, we examined whether treating hens with melatonin would affect eggshell thickness and improve skeletal performance, thereby reducing skeletal and egg shell defects. Birds were given a diet containing either low (30 µg/kg), medium (300 µg/kg), or high (3 mg/kg) concentrations of melatonin, or control feed through approximately one laying cycle. We examined the weight, length, and strength of egg, femur, tibia, and keel. Hens treated with a high concentration of melatonin showed significant strengthening in their femur and tibia, as measured by maximum force sustained and breaking force, compared to controls. Egg weights from hens treated with melatonin were significantly greater than those from hens that were not treated with melatonin. Conversely, egg shell mass of hens treated with melatonin was significantly lower than those of hens not treated with melatonin. Our data suggest that melatonin may affect the allocation of calcium to bone at the expense of egg shell mineralization.

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Section: Discussionmentioning

confidence: 99%

The Effects of Melatonin on the Physical Properties of Bones and Egg Shells in the Laying Hen

et al. 2013

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“…The strength of the dietary supplement lies in the rational combination of these three nutrients given the potent synergy between the effect of melatonin, magnesium, and zinc. 28,47 Moreover, the melatonin, magnesium, and zinc supplement conveyed in pear pulp appears to be safe. No significant unwanted side or adverse effects were observed in the treated group, as reported in previous studies.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Melatonin, Magnesium, and Zinc on Primary Insomnia in Long-Term Care Facility Residents in Italy: A Double-Blind, Placebo-Controlled Clinical Trial

Rondanelli

Opizzi

Monteferrario

et al. 2011

Journal of the American Geriatrics Society

103

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“…Tissue levels of zinc and copper decrease with aging in animals [13][14][15], but previously no data has been available regarding animal or human vaginal tissues. However, in the human uterus (corpus) during menopause, copper levels were seen to rise as zinc levels fell [23].…”

Section: Discussionmentioning

confidence: 99%

“…Animal experiments revealed that zinc affects the extracellular matrix of the vagina. Also, in aging mice and rats, the tissue concentration of zinc and copper decreases [13][14][15]. Histological and histochemical pictures of vaginas from mice with a zinc-deficient diet look similar to ovariectomized animals.…”

Section: Introductionmentioning

confidence: 85%

Evaluation of zinc and copper levels in vaginal tissues and whole blood: correlation with age

Csikós¹,

Kozma

Baranyai

et al. 2021

BMC Women's Health

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Background Zinc and copper are essential trace elements and play a crucial role in the homeostasis of connective tissues. In this study, we aimed to define zinc and copper levels in the vaginal tissue and establish whether a correlation exists between the zinc and copper levels either or both in whole blood or vaginal tissue samples and whether the finding correlates with the age of the patient or at least with her menopausal status. Methods We collected whole blood and vaginal tissue samples from 32 women and measured their zinc and copper levels by inductively coupled plasma optical emission spectrometry. We have performed Student's t test to evaluate the differences in the mean levels of trace elements and multiple regression to evaluate the association between vaginal tissue zinc/copper levels and age, menopausal status, number of vaginal deliveries, and zinc/copper blood levels. Results Zinc levels were significantly higher in both the vaginal tissues and whole blood samples than copper levels (p < 0.01). In the vaginal tissue samples, a strong positive correlation could be detected between zinc and copper levels (r = 0.82, p < 0.01). In the vaginal tissue, a negative correlation was found for zinc and copper levels with the age of women (r = − 0.27, p = 0.04 and r = − 0.56, p < 0.01). Multiple linear regression model (age, menopausal status, vaginal delivery and copper/zinc blood levels) showed that only age remained a significant predictor for zinc and copper vaginal tissues levels (p = 0.03, 95% CI − 2.28 to − 0.06; p = 0.004, 95% CI − 1.76 to − 0.34). Conclusions Zinc and copper levels in the vaginal tissue decline with age. Out of the examined variables (age, menopausal status, vaginal delivery, and copper/zinc levels), only age is a significant predictor of vaginal zinc/copper levels.

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Age-Related Changes in Tissue and Plasma Zinc Levels: Modulation by Exogenously Administered Melatonin

Cited by 9 publications

References 30 publications

The Effects of Melatonin on the Physical Properties of Bones and Egg Shells in the Laying Hen

The Effects of Melatonin on the Physical Properties of Bones and Egg Shells in the Laying Hen

The Effect of Melatonin, Magnesium, and Zinc on Primary Insomnia in Long-Term Care Facility Residents in Italy: A Double-Blind, Placebo-Controlled Clinical Trial

Evaluation of zinc and copper levels in vaginal tissues and whole blood: correlation with age

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