Age-related changes in the number of cresyl-violet-stained, parvalbumin and NMDAR 2B expressing neurons in the human spiral ganglion

Kaur, Charanjeet; Saini, Shubhi; Pal, Indra; Kumar, Pavnesh; Sati, Hem Chandra; Jacob, Tony George; Bhardwaj, D.N.; Roy, Tara Sankar

doi:10.1016/j.heares.2020.107883

Cited by 8 publications

(4 citation statements)

References 89 publications

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“…8 H–J ( Xing, et al., 2012 ). These results are consistent with previous human temporal bone studies showing age-related loss of spiral ganglion cells ( Kaur, et al., 2020 ; Makary, et al., 2011 ). In addition, myelin degeneration and myelinated fiber loss identified in the cochleas of the older donors suggests that dysfunction of myelinating Schwann cells may contribute to auditory nerve pathology and the subsequent decline of auditory function in neural presbyacusis.…”

Section: Consequences Of Peripheral Declines and Neural Presbyacusissupporting

confidence: 93%

Translational and interdisciplinary insights into presbyacusis: A multidimensional disease

et al. 2021

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Highlights Presbyacusis presents with metabolic, neural, and/or sensory phenotypes. Reduced endocochlear potential is likely to be a key contributor to presbyacusis. Genetic factors contribute to presbyacusis, including single-gene variants. There appear to be downstream effects of presbyacusis on brain function and structure.

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Section: Consequences Of Peripheral Declines and Neural Presbyacusissupporting

confidence: 93%

Translational and interdisciplinary insights into presbyacusis: A multidimensional disease

et al. 2021

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“…Recent human temporal bone studies demonstrate a sharp decline in spiral ganglion population starting in the mid-fifties with continued decline with increasing age. 48 Human temporal bones with genetic conditions causing loss of hair cells such as Usher 1B (myosin VII mutation) showed significant loss of not only hair cells but also spiral ganglion neurons demonstrating that loss of peripheral trophic support also results in human spiral ganglion loss. 49 This suggests that in humans both aging and loss of trophic support can reduce spiral ganglion populations, which in turn can affect CI outcomes.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Profiling in the Perilymph of Cochlear Implant Patients: Identifying Markers that Correlate to Audiological Outcomes

et al. 2021

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Hypothesis MicroRNA (miRNA) expression profiles from human perilymph correlate to post cochlear implantation (CI) hearing outcomes. Background The high inter-individual variability in speech perception among cochlear implant recipients is still poorly understood. MiRNA expression in perilymph can be used to characterize the molecular processes underlying inner ear disease and to predict performance with a cochlear implant. Methods Perilymph collected during CI from 17 patients was analyzed using microarrays. MiRNAs were identified and multivariable analysis using consonant-nucleus-consonant testing at 6 and 18 months post implant activation was performed. Variables analyzed included age, gender, preoperative pure tone average (PTA), and preoperative speech discrimination (word recognition [WR]). Gene ontology analysis was performed to identify potential functional implications of changes in the identified miRNAs. Results Distinct miRNA profiles correlated to preoperative PTA and WR. Patients classified as poor performers showed downregulation of six miRNAs that potentially regulate pathways related to neuronal function and cell survival. Conclusion Individual miRNA profiles can be identified in microvolumes of perilymph. Distinct non-coding RNA expression profiles correlate to preoperative hearing and postoperative cochlear implant outcomes.

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“…It is now widely accepted that over-activation of NMDARs leads to the development of AD ( Xu et al, 2021 ; Abad-Perez et al, 2023 ). However, recent studies have found that NMDARs are not only expressed in the cranial brain, but also in inner hair cells (IHCs), and that overactivation of NMDARs also results in Glu release in IHCs ( Tang et al, 2014 ; Kaur et al, 2020 ; Song et al, 2021 ). Excessive Glu release causes excitatory neurotoxic effects, reducing the number of ribbon synapses in the cochlea and altering synaptic morphology, resulting in impaired signaling of the cochlear nerve and affecting the patient’s hearing ( Hong et al, 2018 ).…”

Section: Hypothesismentioning

confidence: 99%

Sensorineural hearing loss and cognitive impairment: three hypotheses

Zhao,

Wang,

Cui

et al. 2024

Front. Aging Neurosci.

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Sensorineural hearing loss (SNHL) is a category of hearing loss that often leads to difficulty in understanding speech and other sounds. Auditory system dysfunction, including deafness and auditory trauma, results in cognitive deficits via neuroplasticity. Cognitive impairment (CI) refers to an abnormality in the brain’s higher intellectual processes related to learning, memory, thinking and judgment that can lead to severe learning and memory deficits. Studies have established a strong correlation between SNHL and CI, but it remains unclear how SNHL contributes to CI. The purpose of this article is to describe three hypotheses regarding this relationship, the mainstream cognitive load hypothesis, the co-morbidity hypothesis, and the sensory deprivation hypothesis, as well as the latest research progress related to each hypothesis.

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Age-related changes in the number of cresyl-violet-stained, parvalbumin and NMDAR 2B expressing neurons in the human spiral ganglion

Cited by 8 publications

References 89 publications

Translational and interdisciplinary insights into presbyacusis: A multidimensional disease

Translational and interdisciplinary insights into presbyacusis: A multidimensional disease

MicroRNA Profiling in the Perilymph of Cochlear Implant Patients: Identifying Markers that Correlate to Audiological Outcomes

Sensorineural hearing loss and cognitive impairment: three hypotheses

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