Age-related changes in the metoclopramide-induced prolactin release in nulliparous women

Parra, Adalberto; Alarcón, José; Gaviño, Fernando Gaviño; Ramírez, A; Monteros, A. Espinosa de los

doi:10.1016/s0015-0282(16)56032-4

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…For example, lower concentrations of serum dehydroepiandrosterone sulfate (DHEAS) and dehydroepiandrosterone (DHEA) have been associated with a first fullterm pregnancy rather than increasing parity (46,47). Lower basal serum prolactin levels have been found in primiparas than nulliparas (48,49) independent of age, and lower levels in parous women were unrelated to number of pregnancies (48). Hormonal changes of pregnancy that promote adipose tissue gain, retention, and/or redistribution resulting in insulin resistance may influence blood lipid metabolism, but little is known about these associations postpartum.…”

Section: Discussionmentioning

confidence: 99%

Long-term Plasma Lipid Changes Associated with a First Birth: The Coronary Artery Risk Development in Young Adults Study

Gunderson

Lewis

Murtaugh³

et al. 2004

American Journal of Epidemiology

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Previous studies have reported declines in high density lipoprotein (HDL) cholesterol 1-2 years after pregnancy. In 1986-1996, the authors prospectively examined the association between childbearing and changes in fasting plasma lipids (low density lipoprotein, HDL, and total cholesterol; triglycerides) among 1,952 US women (980 Black, 972 White) in the Coronary Artery Risk Development in Young Adults study. Repeated-measures multiple linear regression was used to examine lipid changes over three time intervals (baseline to years 5, 7, and 10) in time-dependent follow-up groups: P0 (0 pregnancies), P1 (>/=1 miscarriages/abortions), B1 (1 birth), and B2 (>/=2 births). Means stratified by race and baseline parity (nulliparous or parous) were fully adjusted for study center, time, height, baseline diet, and other baseline and time-dependent covariates (age, smoking, education, weight, waist circumference, alcohol intake, oral contraceptive use, physical activity, short pregnancies). For both races, fully adjusted HDL cholesterol declines of -3 to -4 mg/dl were associated with a first birth versus no pregnancies during follow-up (p < 0.001). Higher-order births were not associated with greater declines in HDL cholesterol (B2 similar to B1, no association among women parous at baseline). In Whites, total and low density lipoprotein cholesterol declines were associated with follow-up births. HDL cholesterol declines of -3 to -4 mg/dl after a first birth persisted during the 10 years of follow-up independent of weight, central adiposity, and selected behavior changes.

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Section: Discussionmentioning

confidence: 99%

Long-term Plasma Lipid Changes Associated with a First Birth: The Coronary Artery Risk Development in Young Adults Study

Gunderson

Lewis

Murtaugh³

et al. 2004

American Journal of Epidemiology

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“…36,37 Yet, time interval from menarche to ®rst ever birth may not only represent the in¯uence of a previous pregnancy at a young age, but the in¯uence of gestational hormones on body fat accumulation among women who may be physically immature despite their adult chronologic age (eg late age at menarche and short interval to ®rst birth). The reported long-term effects of a ®rst full-term pregnancy on subsequent hormonal development include lower basal and stimulated serum prolactin levels for parous compared to nulliparous women, 38 as well as increases in these levels according to chronological age at ®rst full-term pregnancy and time since ®rst full-term pregnancy. 39 It is possible that these pituitary hormones may in¯uence body weight regulation, particularly during the postpartum period.…”

Section: Discussionmentioning

confidence: 99%

The relative importance of gestational gain and maternal characteristics associated with the risk of becoming overweight after pregnancy

2000

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OBJECTIVES: To assess the relationships between gestational gain, raceaethnicity, reproductive history, age, education and the risk of becoming overweight after pregnancy. STUDY DESIGN: Prospective cohort study of adult women from four raceaethnicity groups who had two consecutive births between 1980 and 1990 at the University of California, San Francisco (UCSF). MEASUREMENTS: Height and pregravid weights for each pregnancy were self-reported. Women were classi®ed as overweight or not overweight according to the Institute of Medicine (IOM) criteria for pregnancy. Gestational gain was de®ned as the difference between the pregravid weight and the last weight before delivery of the ®rst study pregnancy. SUBJECTS: 1300 healthy women aged 18 ± 41 y who had a singleton, full-term, live birth (index or ®rst study pregnancy) followed by a second birth. Self-reported pregravid weights and heights were used to calculate body mass index (BMI). Women with a pregravid BMI below 26.0 kgam 2 before the index pregnancy were classi®ed as not overweight (n 1128). Overweight status following the index pregnancy was based on pregravid BMI for the second pregnancy. RESULTS: Seventy-two women (6.4%) became overweight following the index pregnancy. Statistically signi®cant independent predictors of the risk of becoming overweight included: maternal age 24 ± 30 vs above 30 y, high gestational gain, short interval from menarche to ®rst ever birth (`8 y), and young age at menarche (`12 y). The risk of becoming overweight was increased 2.5 ± 3 times for each of these risk factors. Whites were 4.5 times more likely to become overweight than Asians, but blacks and Hispanics did not appear to differ from whites. Parity, time interval, smoking habit, education, marital status and other factors were not associated with the risk of becoming overweight. CONCLUSIONS: These ®ndings suggest that young age at menarche, maternal age and short time from menarche to ®rst ever birth may be as important as high gestational weight gain in determining the risk of becoming overweight after pregnancy.

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“…In this case Glucose insulin ratio-6.094 (fasting G/I ratio was > 4.5.) [16,17] showing insulin resistance. However, LH/FSH ratio was within normal limits.…”

Section: Discussionmentioning

confidence: 99%

A case of infertility due to PCOS treated successfully with homoeopathy

Rath¹

2020

Int. J. Homoeopathic Sci.

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Infertility is defined as "the inability to conceive after multiple sustained attempts of unprotected intercourse for at least 2years. Polycystic ovarian syndrome (PCOS) which affects 8-10% of reproductive-aged females is the most common endocrine cause of infertility. Earlier reports in literature have highlighted the role of individualized homoeopathic treatment in the management of PCOS with infertility. A case report of successful management of secondary infertility due to PCOS with homoeopathic treatment presented herewith. A 31 years old obese lady presented to OPD of CRI(H),NOIDA with clinical presentation of PCOS and secondary infertility. She was diagnosed as PCOS based on Androgen society and Rotterdam criteria and managed on the lines of individualized homoeopathic medicine Sepia and followed for a period of 2years. Regularization of menstrual cycle, reduction in serum testosterone level, significant improvement in insulin sensitivity, normalization of ultrasound pattern of ovaries followed with conception and normal delivery with homoeopathic medicine were observed.

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Age-related changes in the metoclopramide-induced prolactin release in nulliparous women

Cited by 9 publications

References 23 publications

Long-term Plasma Lipid Changes Associated with a First Birth: The Coronary Artery Risk Development in Young Adults Study

Long-term Plasma Lipid Changes Associated with a First Birth: The Coronary Artery Risk Development in Young Adults Study

The relative importance of gestational gain and maternal characteristics associated with the risk of becoming overweight after pregnancy

A case of infertility due to PCOS treated successfully with homoeopathy

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