Age-Related Changes in the Melatonin and Thymulin Biorhythms as Risk Factors for Human Neurodegenerative Diseases

Labunets, I. F.

doi:10.31031/ggs.2017.01.000506

Cited by 3 publications

(2 citation statements)

References 40 publications

(59 reference statements)

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“…Other authors and ourselves found night time peak of blood thymulin level in adult human subjects [17,34]. We revealed season fluctuations in the thymulin level in adult healthy subjects and their disturbances in aging [18,35]. It is characteristic of elderly human subjects that age changes of the rhythmicity of immune system functions coincide with desynchronosis of the thymic endocrine function [8,18,27].…”

Section: Healthy Subjectssupporting

confidence: 50%

Changes in Melatonin Biorhythms and Immune- Neuroendocrine Interactions in Oncological Patients of Different Ages

F¹

2018

GGS

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The frequency of tumors in aging increases worldwide. The use of chronobiological approaches in studying circadian and circannul rhythms of various organism functions may be perspective for effective diagnosis, prevention and treatment of oncologic patients of different age. This review presents the data about changes of the basic components in control system of the biorhythms in aging and tumor development. We present the results of our study about the biorhythms of the immune system in healthy adult subjects and their changes in aging and cancer as well as their links with the disturbances in rhythmicity of thymic hormone thymulin. The role of disturbances in the interrelations of biorhythms melatonin and cortisol levels for development of desynchronosis thymulin and immune system functions in aging and cancer are underlined.The importance of using chronobiological approaches for estimation of changes in the immune and neuroendocrine system in the oncopatients and the use of melatonin as synchronizing agent in the their basic treatment schemes is substantiated. Schemes of melatonin administration should be based on age-related changes of the sensitivity immune and endocrine systems to its influence.

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Section: Healthy Subjectssupporting

confidence: 50%

Changes in Melatonin Biorhythms and Immune- Neuroendocrine Interactions in Oncological Patients of Different Ages

F¹

2018

GGS

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“…Organisms use both circadian and circannual rhythms for time measurements. The rhythms are linked to fluctuating factors such as light and temperature [ 1 , 2 , 3 ]. Light strongly affects behavioural and metabolic rhythms along with a host of numerous processes that determine the temporally correct expression of genes [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing

Rezzani

Franco

Hardeland

et al. 2020

IJMS

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For years the thymus gland (TG) and the pineal gland (PG) have been subject of increasingly in-depth studies, but only recently a link that can associate the activities of the two organs has been identified. Considering, on the one hand, the well-known immune activity of thymus and, on the other, the increasingly emerging immunological roles of circadian oscillators and the rhythmically secreted main pineal product, melatonin, many studies aimed to analyse the possible existence of an interaction between these two systems. Moreover, data confirmed that the immune system is functionally associated with the nervous and endocrine systems determining an integrated dynamic network. In addition, recent researches showed a similar, characteristic involution process both in TG and PG. Since the second half of the 20th century, evidence led to the definition of an effectively interacting thymus-pineal axis (TG-PG axis), but much has to be done. In this sense, the aim of this review is to summarize what is actually known about this topic, focusing on the impact of the TG-PG axis on human life and ageing. We would like to give more emphasis to the implications of this dynamical interaction in a possible therapeutic strategy for human health. Moreover, we focused on all the products of TG and PG in order to collect what is known about the role of peptides other than melatonin. The results available today are often unclear and not linear. These peptides have not been well studied and defined over the years. In this review we hope to awake the interest of the scientific community in them and in their future pharmacological applications.

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The Relationships of Age-Related Changes in the Biorhythms of the Thymus Endocrine Function and Pineal Melatonin-Producing Function in Healthy People

Labunets¹

2024

Sleep Medicine - Asleep or Awake?

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The circadian and circannual rhythms play the main role in the adaptation of human immune and pituitary-adrenal systems functioning to the changing photoperiod. The rhythmicity of thymus endocrine function is an important part of the chronobiological organization of immune system. The pineal hormone melatonin is the central regulator of rhythms of healthy human organism functions and involves thymus hormones (namely FTS/thymulin) in synchronizing influence on the immune system functioning. Age-related changes of thymus hormone and melatonin rhythms in healthy people are linked and precede the aging desynchronosis of immune and pituitary-adrenal system functions. In healthy male versus female the above changes occur at earlier life periods and are more pronounced. The thymus endocrine function does not completely disappear in the elderly/old people and is able to respond to the synchronizing influence of melatonin with part of the adrenal gland. Age-related changes in the circadian and circannual rhythms of the thymus hormone, melatonin, immune system, and adrenal gland functions become more pronounced at the development of age-associated diseases (neurodegenerative, cardiovascular, oncological). Melatonin can be perspective medicine for restoration of disturbed rhythmicity of thymus, immune system, and adrenal glands in accelerated human aging and in patients with age-dependent diseases.

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Age-Related Changes in the Melatonin and Thymulin Biorhythms as Risk Factors for Human Neurodegenerative Diseases

Cited by 3 publications

References 40 publications

Changes in Melatonin Biorhythms and Immune- Neuroendocrine Interactions in Oncological Patients of Different Ages

Changes in Melatonin Biorhythms and Immune- Neuroendocrine Interactions in Oncological Patients of Different Ages

Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing

The Relationships of Age-Related Changes in the Biorhythms of the Thymus Endocrine Function and Pineal Melatonin-Producing Function in Healthy People

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