2012
DOI: 10.1016/j.bbi.2011.09.013
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Age-related changes in the hippocampus (loss of synaptophysin and glial–synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL

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Cited by 48 publications
(37 citation statements)
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“…The decrease in CD200 concurs with our previous findings (Lyons et al, 2007a) and the age-related decrease in synaptophysin in hippocampus is similar to that described previously in the dentate gyrus (Davies et al, 2003;Mullany and Lynch, 1997) and is consistent with the finding that CD200 is expressed at synapses (Ojo et al, 2011).…”
Section: Synaptophysin and Cd200 Are Decreased With Agesupporting
confidence: 82%
See 1 more Smart Citation
“…The decrease in CD200 concurs with our previous findings (Lyons et al, 2007a) and the age-related decrease in synaptophysin in hippocampus is similar to that described previously in the dentate gyrus (Davies et al, 2003;Mullany and Lynch, 1997) and is consistent with the finding that CD200 is expressed at synapses (Ojo et al, 2011).…”
Section: Synaptophysin and Cd200 Are Decreased With Agesupporting
confidence: 82%
“…These findings confirm the previously-reported age-related decrease in CD200 (Lyons et al, 2007a) and suggest that the loss of synapses, indicated by decreased synaptophysin, might contribute to this change. Interestingly, CD200 has been reported to be expressed on presynaptic terminals where co-localization with synaptophysin has been observed (Ojo et al, 2011). There was no evidence of an agerelated change in CD200R.…”
Section: Discussionmentioning
confidence: 68%
“…16 FGL proved to exert beneficial effects in different models of neurological or psychiatric diseases. 6,7,[11][12][13][14]20 In the present study, repeated administration of the peptide mimetic FGL affected kindling progression as well as associated alterations in the number of neuronal progenitor cells and early postmitotic cells. The impact of FGL on kindling progression is indicated by a reduced number of stimulations necessary to induce a generalized seizure.…”
Section: ■ Results and Discussionmentioning
confidence: 89%
“…6,13,14 Pharmacokinetic studies have confirmed a relevant brain penetration rate of the peptide in rats and humans. FGL concentrations proved to be detectable in the cerebrospinal fluid of rats within 10 min following subcutaneous administration resulting in stable concentrations up to 5 h. 19 In humans, concentrations in the cerebrospinal fluid have been analyzed following intranasal administration, thus confirming relevant brain access in translational studies.…”
Section: ■ Results and Discussionmentioning
confidence: 99%
“…Even during oestrus cycle there is an intense fluctuation in dendritic density in rodents. Furthermore, ovariectomy or menopause itself results in a significant decrease of synaptic and dendritic density (Ojo et al, 2011;Woolley and McEwen, 1992). Data on estrogen effect also suggest that it acts directly at synapses by activating second messenger signaling, resulting in a rapid altering in neuronal excitability, synaptic transmission, and/or synaptic plasticity (Woolley, 2007).…”
Section: Estrogen: Afforded Protection and Plasticity Following Brainmentioning
confidence: 99%