Age-Related Changes in the Content of Sirtuin 1 in Human Dermal Fibroblasts

Golubtsova, N. N.; Filippov, F. N.; Гунин, А. Г.

doi:10.1134/s207905701704004x

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…The results suggest involvement of sirtuin 1 pathway in ∆Np63-induced aging model. Further studies on cell cultures and human tissues confirmed age-dependent downregulation of SIRT1 gene expression [18,19,21]. Serial passage of human dermal fibroblasts, which is a model of replicative senescence, revealed decrease in extracellular matrix components accompanied by SIRT1 reduction [19].…”

Section: Cutaneous Sirtuin 1 Expression Decreases With Agementioning

confidence: 77%

“…Another study on SIRT1 expression in human skin biopsies, retrieved from females aged 20-67, revealed age-dependent decrease in SIRT1 in dermal fibroblasts [18]. In line with this, Golubstova et al [21]. performed an analysis of tissue specimens from human fetuses and people aged between 20-week gestation and 85 years.…”

Section: Cutaneous Sirtuin 1 Expression Decreases With Agementioning

confidence: 83%

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Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review

Bielach-Bazyluk

Zbroch

Myśliwiec

et al. 2021

Cells

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Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic causative factors of aging. Intrinsic aging is related to compromised cellular proliferative capacity, and may be accelerated by harmful environmental influences with the greatest significance of ultraviolet radiation exposure, contributing not only to premature aging, but also to skin carcinogenesis. The overall skin cancer burden and steadily increasing global antiaging market provide an incentive for searching novel targets to improve skin resistance against external injury. Sirtuin 1, initially linked to extension of yeast and rodent lifespan, plays a key role in epigenetic modification of proteins, histones, and chromatin by which regulates the expression of genes implicated in the oxidative stress response and apoptosis. The spectrum of cellular pathways regulated by sirtuin 1 suggests its beneficial impact on skin aging. However, the data on its role in carcinogenesis remains controversial. The aim of this review was to discuss the relevance of sirtuin 1 in skin aging, in the context of intrinsic factors, related to genetic premature aging syndromes, as well as extrinsic modifiable ones, with the assessment of its future application. PubMed were searched from inception to 4 January 2021 for relevant papers with further search carried out on ClinicalTrials.gov. The systematic review included 46 eligible original articles. The evidence from numerous studies proves sirtuin 1 significance in both chronological and premature aging as well as its dual role in cancer development. Several botanical compounds hold the potential to improve skin aging symptoms.

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Section: Cutaneous Sirtuin 1 Expression Decreases With Agementioning

confidence: 77%

Section: Cutaneous Sirtuin 1 Expression Decreases With Agementioning

confidence: 83%

Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review

Bielach-Bazyluk

Zbroch

Myśliwiec

et al. 2021

Cells

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“…In mouse models of photoaging, mTOR components are increased and AMPK is decreased [72,73] . Similarly, sirtuins are noted to be decreased in fibroblasts isolated from both sunexposed and photoaged individuals [74][75][76] . While these alterations infer that aged skin is signaling a state of nutrient excess, metabolomic profiling of epidermal samples suggests there is downregulation of anabolic biosynthetic pathways and upregulation of catabolic pathways, consistent with an overall impaired function of nutrient sensing [77,78] .…”

Section: Impaired Nutrient Sensingmentioning

confidence: 91%

Aging skin and non-surgical procedures: a basic science overview

Vandiver¹,

Hogan²

2020

Plast Aesthet Res

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Skin aging is a major cosmetic concern and associated with extensive changes in skin function and structure. The understanding of the basic science underlying skin aging is rapidly progressing, anchored around nine fundamental hallmarks of aging defined in 2013. Here we present the evidence for the relevance of each hallmark of aging to skin aging, emphasizing the uniquely prominent roles of oxidative damage and the extracellular matrix in photoaging. We review the existing evidence for how established treatments of skin aging target each fundamental hallmark and discuss targets for potential future treatments.

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“…Sirtuins, another nutrient-sensor in the opposite direction to IIS and mTOR, the role of which in skin aging has been well reviewed in a systemic review including 37 experimental and 16 human observation studies [ 19 ]. In skin biopsies from human donors (fetuses at pregnant age 20 to 40 week, and people from birth to 85 years old), the authors found a decreased content in sirtuin 1 accompanied by reduced proliferation of dermal fibroblasts in aged groups [ 20 ]. In parallel, another study with skin samples from females aged 20 ~ 67 also demonstrated a declined protein level of sirtuin 1 and accumulated ROS levels in elder groups [ 21 ].…”

Section: Hallmarks Of Agingmentioning

confidence: 99%

“…Age-related: sirtuin 1 content ↓; proliferation of dermal fibroblasts ↓ [20] Skin biopsies of females aged 20-67 Age-related: sirtuin…”

Section: Increased Mtorc2 Pathwaymentioning

confidence: 99%

Hallmarks of Skin Aging: Update

Jin¹,

Li²,

Zong³

et al. 2023

Aging and disease

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Aging is defined as impaired physiological integrity, decreased function, increased susceptibility to external risk factors and various diseases. Skin, the largest organ in our body, may become more vulnerable to insult as time goes by and behave as aged skin. Here, we systemically reviewed three categories including seven hallmarks of skin aging. These hallmarks including genomic instability and telomere attrition, epigenetic alterations and loss of proteostasis, deregulated nutrient-sensing, mitochondrial damage and dysfunction, cellular senescence, stem cell exhaustion/dysregulation, and altered intercellular communication. These seven hallmarks can generally be divided into three categories including (i) causes of damages as primary hallmarks in skin aging; (ii) responses to damage as antagonistic hallmarks in skin aging; and (iii) culprits of the phenotype as integrative hallmarks in skin aging.

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Age-Related Changes in the Content of Sirtuin 1 in Human Dermal Fibroblasts

Cited by 4 publications

References 17 publications

Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review

Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review

Aging skin and non-surgical procedures: a basic science overview

Hallmarks of Skin Aging: Update

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