Age‐related changes in the composition of the cornified envelope in human skin

Rinnerthaler, Mark; Duschl, Jutta; Steinbacher, Peter; Salzmann, Manuel; Bischof, Johannes; Schüller, M.; Wimmer, Heinz; Peer, Thomas; Bauer, Johann; Richter, Klaus

doi:10.1111/exd.12135

Cited by 81 publications

(77 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(17)(18)(19)(20)(21)(22)(23) (C) Effect of environmental factors which lead to FLG proteolysis such as low ambient humidity, skin irritants, pruritus / excoriations / mechanical damage, age and water. (24,25) Later will be reviewed the genetic variation of FLG.…”

Section: Factors Influence On Skin Barrier Dysfunctionsmentioning

confidence: 99%

Molecular Genetic of Atopic Dermatitis : An Update

Al‐Shobaili

Ahmed

Alnomair

et al. 2016

IJHS

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The pathogenesis of AD remains unclear, but the disease results from dysfunctions of skin barrier and immune response, where both genetic and environmental factors play a key role. Recent studies demonstrate the substantial evidences that show a strong genetic association with AD. As for example, AD patients have a positive family history and have a concordance rate in twins. Moreover, several candidate genes have now been suspected that play a central role in the genetic background of AD. In last decade advanced procedures similar to genome-wide association (GWA) and single nucleotide polymorphism (SNP) have been applied on different population and now it has been clarified that AD is significantly associated with genes of innate/adaptive immune systems, human leukocyte antigens (HLA), cytokines, chemokines, drug-metabolizing genes or various other genes. In this review, we will highlight the recent advancements in the molecular genetics of AD, especially on possible functional relevance of genetic variants discovered to date.

show abstract

Section: Factors Influence On Skin Barrier Dysfunctionsmentioning

confidence: 99%

Molecular Genetic of Atopic Dermatitis : An Update

Al‐Shobaili

Ahmed

Alnomair

et al. 2016

IJHS

View full text Add to dashboard Cite

show abstract

“…These proteins are important components of the cornified envelope cross-linked to loricrin during cornified envelope formation [78]. Having multiple cysteine residues, SPRRs demonstrate the capability of quenching ROS by forming intramolecular disulfide bonds [79]. It was reported that, during the process of aging, the cornified envelope is intensely altered [79].…”

Section: Antioxidant Enzymesmentioning

confidence: 99%

“…Having multiple cysteine residues, SPRRs demonstrate the capability of quenching ROS by forming intramolecular disulfide bonds [79]. It was reported that, during the process of aging, the cornified envelope is intensely altered [79]. However, elevated levels of SPRRs were found, which possibly indicate the presence of a compensation mechanism of the aged cornified envelope [79].…”

Section: Antioxidant Enzymesmentioning

confidence: 99%

“…It was reported that, during the process of aging, the cornified envelope is intensely altered [79]. However, elevated levels of SPRRs were found, which possibly indicate the presence of a compensation mechanism of the aged cornified envelope [79]. The discovery of SPRRs' anti-oxidative capabilities emphasizes the tight link between the cornified envelope function as an epidermal barrier against the environment and its anti-oxidative line of defense, suggesting an efficient evolutionary process.…”

Section: Antioxidant Enzymesmentioning

confidence: 99%

See 1 more Smart Citation

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

et al. 2016

View full text Add to dashboard Cite

Abstract:The skin, being the largest organ of the body, functions as a barrier between our body and the environment. It is consistently exposed to various exogenous and endogenous stressors (e.g., air pollutants, ionizing and non-ionizing irradiation, toxins, mitochondrial metabolism, enzyme activity, inflammatory process, etc.) producing reactive oxygen species (ROS) and physical damage (e.g., wounds, sunburns) also resulting in reactive oxygen species production. Although skin is equipped with an array of defense mechanisms to counteract reactive oxygen species, augmented exposure and continued reactive oxygen species might result in excessive oxidative stress leading to many skin disorders including inflammatory diseases, pigmenting disorders and some types of cutaneous malignancy. The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance and of defensive enzymes such as the phase II enzymes. Induction of the Keap1-Nrf2 pathway may have a beneficial effect in the treatment of a large number of skin disorders by stimulating an endogenous defense mechanism. However, prolonged and enhanced activation of this pathway is detrimental and, thus, limits the therapeutic potential of Keap1-Nrf2 modulators. Here, we review the consequences of oxidative stress to the skin, and the defense mechanisms that skin is equipped with. We describe the challenges of maintaining skin redox balance and its impact on skin status and function. Finally, we suggest a novel strategy for maintenance of skin redox homeostasis by modulating the Keap1-Nrf2 pathway using nanotechnology-based delivery systems.

show abstract

“…The stratum corneum lipid composition changes over the course of life as well as in diabetes [2]. Filaggrin, an integral part of the cornified envelope, linking corneocytes to the intercellular lipids, decreases with age [3]. Its degradation products essentially contribute to the natural moisturizing factor [4], which frequently declines in aged male skin [5].…”

Section: Introductionmentioning

confidence: 99%

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of <b><i>Lactococcus lactis</i></b> Emulsion in Humans

Hausmann

Hertz-Kleptow

Zoschke

et al. 2019

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Background/Aims: The skin provides protection against chemical, physical, and biological stressors, yet the skin morphology changes over the course of life. These changes might affect the skin barrier function and facilitate the onset of age-related diseases. Since orally applied lactic acid bacteria ameliorate signs of aged and atopic skin, we investigated the effects of a topically applied Lactococcus lactis emulsion. Methods: In a blinded, randomized, vehicle-controlled trial, we studied topical Lactococcus effects both in vitro and in 20 healthy female volunteers. Commercially available reconstructed human epidermis (RHE) was treated for 4 days (once daily) and volar forearms were treated for 30 days (twice daily). Results: Lactococcus formulations improve the skin barrier in RHE as shown by increased filaggrin and human β-defensin-2 expression as well as by the 23% declined mean apparent permeability coefficients for caffeine. A reduction of 18% in transepidermal water loss confirms this effect in humans. Moreover, Lactococcus emulsion optimized skin hydration and surface pH. Skin irritation was not detected. Conclusions: Lactococcus emulsion improved the skin barrier function with good biocompatibility. Moreover, our study exemplifies the translational predictive capacity of testing on RHE with respect to Lactococcus emulsion.

show abstract

Age‐related changes in the composition of the cornified envelope in human skin

Cited by 81 publications

References 71 publications

Molecular Genetic of Atopic Dermatitis : An Update

Molecular Genetic of Atopic Dermatitis : An Update

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of <b><i>Lactococcus lactis</i></b> Emulsion in Humans

Contact Info

Product

Resources

About