Age-related changes in the biomechanics of healing patellar tendon

Collagen‐platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament

“…3 However, basic science studies of partial ACL transection and patellar tendon healing suggest that the scar formed in skeletally mature animals is actually stronger that that formed in skeletally immature animals. 23,56 As patients with open physes are vulnerable to ACL injury, and stand to have the longest period of disability if premature osteoarthritis occurs, it is clinically important to begin to examine ACL healing in this population; however, the effects of skeletal maturity on ligament healing have yet to be defined and the results obtained here may be less applicable to adult models.…”

The Role of Mechanical Loading in Tendon Development, Maintenance, Injury, and Repair

“…While age-related sarcopenia has been repeatedly documented, the effect of aging on tendon biomechanical properties is inconclusive 74,[79][80][81][82][83] . Methodological differences make study comparisons difficult, although the majority of investigators have suggested that collagen loss occurs in older individuals [84][85][86] .…”

“…A substantial component of age-related strength loss may be the result of inactivity and can be modified by an appropriate exercise program [87][88][89][90][91][92] . Studies have shown that collagen and elastin production, along with collagen fibril diameter and collagen cross-linking, decrease as a result of age 82 . Consequently, tendon tensile strength and stiffness decrease, contributing to injury.…”

Effects of stress shielding and subsequent restressing on mechanical properties of regenerated and residual tissues in rabbit patellar tendon after resection of its central one-third

“…However, the strengths of both tissues at 24 weeks were still significantly lower compared to the control level. Moreover, Dressler et al (2006) have shown that at 26 weeks post-surgery, the maximum stress of the regenerated tissue in one-year-old rabbits reached only 23% of the control level. These phenomena may cause post-operative complications in operated PTs, for example, the disruption of remaining PTs (DeLee and Craviotto, 1991;Marumoto et al, 1996).…”

“…Previous studies in animal models, which simulated graft harvest for the ACL reconstruction surgery using the central one-third PT, have demonstrated inferior material properties of the tissue regenerated in the central defect and the residual PT tissue (Dressler et al, 2006;Miyashita et al, 1997;Tohyama et al, 2003). In these studies, the operated knees were allowed unconfined weight bearing after surgery.…”