Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs

Francuski, Jelena; Radovanović, Anita; Andrić, Nenad; Krstic, V.; Bogdanović, Dragan; Hadžić, V.; Todorović, Vladimir S.; Macanović, Mirjana Lazarević; Petit, Stéphane; Beck-Cormier, Sarah; Guicheux, Jérôme; Gauthier, Olivier; Filipović, Milica Kovačević

doi:10.1016/j.jcpa.2014.09.002

Cited by 12 publications

(18 citation statements)

References 24 publications

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“…In a recent research study in man, the tidemark count poorly and non‐significantly correlated with the human OARSI scores in the middle part of 42 lateral tibial condyles, with OARSI scores ranging from 0 (normal) to 4 (superficial delamination to mid‐zone erosion) (Deng et al, ). These results support the idea, also proposed by other authors (Bonde et al, ; Francuski et al, ; Lane & Bullough, ; Muir et al, ; Oegema et al, ), that tidemark multiplication is not a unique feature of osteoarthritis and can be found in normal animals. OARSI scores in the current study were low.…”

Section: Discussionsupporting

confidence: 92%

“…In the current study, the number of tidemarks was higher in the tibia than in the femur. A difference in number of tidemarks has also been described in dogs (Francuski et al, ). In femoral cartilage, tidemark multiplication was more frequently observed in working dogs than in non‐working dogs, whilst in the tibial cartilage it was more frequently observed in non‐working dogs.…”

Section: Discussionmentioning

confidence: 76%

“…In horses, the number of tidemarks was higher in non‐athletic than in racehorses with articular pathology (Muir et al, ). In non‐working and working German shepherd dogs, the tidemark duplication in the femur and the tibia has been suggested to be related to ageing (Francuski et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Age‐related morphometric changes of the tidemark in the ovine stifle

Hontoir

Pirson

Simon

et al. 2019

Anat Histol Embryol

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Though the ovine stifle is commonly used to study osteoarthritis, there is limited information about the age‐related morphometric changes of the tidemark. The objective of this study was to document the number of tidemarks in the stifle of research sheep without clinical signs of osteoarthritis and of various ages (n = 80). Articular cartilage of the medial and lateral tibial condyles and of the medial and lateral femoral condyles was assessed by histology: (a) to count the number of tidemark; and (b) to assess the OARSI (Osteoarthritis Research Society International) score for structural changes of cartilage. The number of tidemarks varied between anatomical regions, respectively, from 4.2 in the medial femoral condyle to 5.0 in the lateral tibial condyle. The axial part showed a significant higher number of tidemarks than the abaxial part, for all regions except the medial tibial condyle. Whilst the tidemark count strongly correlated with age (Spearman's correlation coefficient = 0.70; 95% confidence interval (95% CI): 0.67–0.73; p < 0.0001), the OARSI score was weakly correlated with age in our cohort of sheep (Spearman's correlation coefficient = 0.25; 95% CI: 0.19–0.30; p < 0.0001). Interestingly, no tidemark was seen in the three animals aged 6 months. Our data indicate that the number of tidemarks increases with age and vary with anatomical region. The regional variation also revealed a higher number of tidemarks in the tibia than in the femur. This could be attributed to the local variation in cartilage response to strain and to the difference in chondrocyte biology and density.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 76%

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Age‐related morphometric changes of the tidemark in the ovine stifle

Hontoir

Pirson

Simon

et al. 2019

Anat Histol Embryol

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“…low-grade, aging-associated chronic inflammation (Franceschi and Bonafe, 2003;Mobasheri et al, 2015). As effective treatments are not available, both OA and DDD show high rates of reoccurrence and slow recovery, often becoming chronic (Henschke et al, 2008;Hoy et al, 2010a;Hoy et al, 2010b).…”

Section: Degenerative Joint Diseasesmentioning

confidence: 99%

“…Physiological mechanical loading can restore the biochemical properties of both tissues, while underloading and overloading reduce tissue function (Gawri et al, 2014;Setton and Chen, 2006;Verteramo and Seedhom, 2007;Wang et al, 2013). ECM turnover is regulated by MMPs and ADAMTS and it is affected by age and degeneration, as the ability of cartilaginous tissues to maintain the ECM declines when both factors increase (Francuski et al, 2014;Illien-Junger et al, 2010;Le Maitre et al, 2004;Molinos et al, 2015;Pauli et al, 2011;Sztrolovics et al, 1997;Wuertz et al, 2009;Yin and Xia, 2014). The effect of osmolarity on the turnover of articular cartilage and IVD ECM is well documented (Amin et al, 2011;Ishihara et al, 1997;Johnson et al, 2014;Wuertz et al, 2007).…”

Section: Trp Channels In Joint Diseasesmentioning

confidence: 99%

The role of transient receptor potential channels in joint diseases

Krupková

Zvick²,

Wuertz‐Kozak³

2017

eCM

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Transient receptor potential channels (TRP channels) are cation selective transmembrane receptors with diverse structures, activation mechanisms and physiological functions. TRP channels act as cellular sensors for a plethora of stimuli, including temperature, membrane voltage, oxidative stress, mechanical stimuli, pH and endogenous as well as exogenous ligands, thereby illustrating their versatility. As such, TRP channels regulate various functions in both excitable and non-excitable cells, mainly by mediating Ca 2+ homeostasis. Dysregulation of TRP channels is implicated in many pathologies, including cardiovascular diseases, muscular dystrophies and hyperalgesia. However, the importance of TRP channel expression, physiological function and regulation in chondrocytes and intervertebral disc (IVD) cells is largely unexplored. Osteoarthritis (OA) and degenerative disc disease (DDD) are chronic age-related disorders that significantly affect the quality of life by causing pain, activity limitation and disability. Furthermore, currently available therapies cannot effectively slow-down or stop progression of these diseases. Both OA and DDD are characterised by reduced tissue cellularity, enhanced inflammatory responses and molecular, structural and mechanical alterations of the extracellular matrix, hence affecting load distribution and reducing joint flexibility. However, knowledge on how chondrocytes and IVD cells sense their microenvironment and respond to its changes is still limited. In this review, we introduced six families of mammalian TRP channels, their mechanisms of activation as well as activation-driven cellular consequences. We summarised the current knowledge on TRP channel expression and activity in chondrocytes and IVD cells and the significance of TRP channels as therapeutic targets for the treatment of OA and DDD.

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