Age-related changes in superoxide dismutase, glutathione peroxidase, catalase and xanthine oxidoreductase/xanthine oxidase activities in the rabbit cornea

Čejková, Jitka; Vejražka, Martin; Plátenı́k, Jan; Stípek, S

doi:10.1016/j.exger.2004.08.006

Cited by 52 publications

(33 citation statements)

References 25 publications

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“…25 It has been previously reported that SOD activity decreases in older animals. 26 In the present study, we showed that mtMnSOD activity decreases with age. But the mechanisms of age-induced reduction of mtMnSOD were not addressed in the present study.…”

Section: Mnsod Activity and Macrophage Apoptosismentioning

confidence: 52%

Age-Induced Reduction in Mitochondrial Manganese Superoxide Dismutase Activity and Tolerance of Macrophages Against Apoptosis Induced by Oxidized Low Density Lipoprotein

Fujimoto

Kobayashi

Ohno

2010

Circ J

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Section: Mnsod Activity and Macrophage Apoptosismentioning

confidence: 52%

Age-Induced Reduction in Mitochondrial Manganese Superoxide Dismutase Activity and Tolerance of Macrophages Against Apoptosis Induced by Oxidized Low Density Lipoprotein

Fujimoto

Kobayashi

Ohno

2010

Circ J

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“…Oxidized lipids decrease the fluidity and increase the permeability of the inner mitochondrial membrane (252). Oxidative damage proteins also increase markedly with age (249). Toxic roles for oxidized proteins have been proposed (i.e.…”

Section: Agingmentioning

confidence: 99%

“…During aging some of the free radical scavenging systems are decreased (249,250) and as a consequence an increased escape of free radicals occurs, targeting lipids, proteins and DNA in proximity to the respiratory chain (251). Oxidized lipids decrease the fluidity and increase the permeability of the inner mitochondrial membrane (252).…”

Section: Agingmentioning

confidence: 99%

Mitochondrial dysfunction in human pathologies

Monsalve¹

2007

Front Biosci

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The integrity of mitochondrial function is fundamental to cell life. The cell demands for mitochondria and their complex integration into cell biology, extends far beyond the provision of ATP. It follows that disturbances of mitochondrial function lead to disruption of cell function, expressed as disease or even death. Mitochondria are major producers of free radical species and also possibly of nitric oxide, and are, at the same time, major targets for oxidative damage. In this review we consider recent developments in our knowledge of how the mitochondrial production of reactive oxygen species (ROS) plays a critical role in several major human pathologies. We will also consider recent advances in our understanding of the molecular mechanisms involved in mitochondrial ROS detoxification.

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“…14) Papers has suggested a role for the alteration of GST expression in the resistance of the lens to oxidative cataracts in murine animals. 50,51) Furthermore, GSTM exhibits a dethiolate activity such as that of thioltransferase, suggesting that GSTM plays an important role in the cleavage of the mixed disulfides produced under oxidative stress. 19,26) These results suggest that GSTs play a role as an important anti-oxidant enzyme under oxidative stress.…”

Section: Resultsmentioning

confidence: 99%