Age‐related changes in scalp topography to novel and target stimuli

Friedman, David; Simpson, Gregory V.; Hamberger, Marla J.

doi:10.1111/j.1469-8986.1993.tb02060.x

Cited by 244 publications

(147 citation statements)

References 43 publications

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“…4). This result is consistent with the common finding in the literature, that young, adult and elderly differ in their ability to inhibit the processing of task irrelevant information resulting in a higher level of general attention during oddball task (Ford and Pfefferbaum 1991;Friedman et al 1993;Anderer et al 1998a;Ford et al 2001). Furthermore, if we analyze the …”

Section: Discussionsupporting

confidence: 80%

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

et al. 2014

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Auditory event-related potentials (AERPs) are widely used in diverse fields of today's neuroscience, concerning auditory processing, speech perception, language acquisition, neurodevelopment, attention and cognition in normal aging, gender, developmental, neurologic and psychiatric disorders. However, its transposition to clinical practice has remained minimal. Mainly due to scarce literature on normative data across age, wide spectrum of results, variety of auditory stimuli used and to different neuropsychological meanings of AERPs components between authors. One of the most prominent AERP components studied in last decades was N1, which reflects auditory detection and discrimination. Subsequently, N2 indicates attention allocation and phonological analysis. The simultaneous analysis of N1 and N2 elicited by feasible novelty experimental paradigms, such as auditory oddball, seems an objective method to assess central auditory processing. The aim of this systematic review was to bring forward normative values for auditory oddball N1 and N2 components across age. EBSCO, PubMed, Web of Knowledge and Google Scholar were systematically searched for studies that elicited N1 and/or N2 by auditory oddball paradigm. A total of 2,764 papers were initially identified in the database, of which 19 resulted from hand search and additional references, between 1988 and 2013, last 25 years. A final total of 68 studies met the eligibility criteria with a total of 2,406 participants from control groups for N1 (age range 6.6-85 years; mean 34.42) and 1,507 for N2 (age range 9-85 years; mean 36.13). Polynomial regression analysis revealed that N1 latency decreases with aging at Fz and Cz, N1 amplitude at Cz decreases from childhood to adolescence and stabilizes after 30-40 years and at Fz the decrement finishes by 60 years and highly increases after this age. Regarding N2, latency did not covary with age but amplitude showed a significant decrement for both Cz and Fz. Results suggested reliable normative values for Cz and Fz electrode locations; however, changes in brain development and components topography over age should be considered in clinical practice.

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Section: Discussionsupporting

confidence: 80%

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

et al. 2014

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“…Target tones were 80 dB SPL and 50 ms in duration. Because the novel sounds had variable rise times and durations (Friedman et al, 1993), responses were imprecisely phase locked and were not analyzed.…”

Section: Tasksmentioning

confidence: 99%

The dependence of P300 amplitude on gamma synchrony breaks down in schizophrenia

et al. 2008

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Introduction-Auditory P300 amplitude reduction in schizophrenia is canonical and may be explained by poor synchronization or reduced power of the underlying neural activity. We asked if patients have reduced synchrony and power, and whether together with P300 amplitude, they make unique or overlapping contributions to the discrimination between patients and controls. We also asked whether people who have large P300s have higher power and greater synchrony of neural activity, and if the relationships between P300 and power and synchrony are different in patients and healthy controls.Methods-We recorded EEG data from 22 controls and 21 patients with schizophrenia (DSM-IV) while they performed an auditory target (p=.10) detection task. We used wavelet analyses to estimate total power and synchrony of delta, theta, alpha, beta, and gamma activity in a 50ms window around the peak of the P300 to the target from the single trial data. We measured P300 amplitude from the average of the single trials, in a 50ms window around its peak.Results and Conclusions-P300 amplitude and delta and theta synchrony were reduced in patients; delta power and synchrony better distinguished between groups than P300 amplitude. In healthy controls, but not patients, gamma synchrony predicted P300 amplitude, but delta did not. In patients, P300 and gamma synchrony are affected by independent factors; the relationship between them is attenuated by an additional pathophysiological process.

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“…This component is called "novelty P3" or "P3a", which has a shorter latency than P3b and has a frontal/central amplitude distribution (Courchesne et al, 1975;Friedman et al, 1993;Squires et al, 1975). This component can be elicited by auditory (Squires et al, 1975), visual (Courchesne et al, 1975), and somatosensory stimuli (Yamaguchi and Knight, 1991).…”

Section: P3b and P3amentioning

confidence: 99%

“…This component was considered to be "P3a", which has been reported when "novel" non-target stimuli were used (Courchesne et al, 1975;Friedman et al, 1993).…”

Section: Stimulus Contextmentioning

confidence: 99%

Stimulus context determines whether non-target stimuli are processed as task-relevant or distractor information

Sawaki

Katayama

2006

Clinical Neurophysiology

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Objective: The P300 event-related brain potential (ERP) was elicited using a visual three-stimulus oddball paradigm (standard 0.70, target 0.15, non-target 0.15) to examine how target/standard stimulus context affects non-target processing.Methods: Target/standard discrimination difficulty (easy or difficult) and non-target /target similarity (similar or dissimilar) were manipulated orthogonally. Participants (N = 13) were instructed to respond to each infrequent target stimulus by pressing a button.Results: Target stimuli in all task conditions elicited P3b, which was affected only by the difficulty of target/standard discrimination. When target/standard discrimination was easy, the amplitude of non-target P3 was larger for similar than for dissimilar non-target. In contrast, when target/standard discrimination was difficult, non-target stimuli elicited P3a, the amplitude of which was larger for dissimilar than for similar non-target. Thus, the P300 component for non-target stimuli and the pattern of the effect of target similarity on each P300 component varied as a function of the target/standard stimulus context. Conclusions:The target/standard stimulus context influences the attentional set for stimulus processing such that it determines whether non-target stimuli are processed as task-relevant or distractor information.

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Age‐related changes in scalp topography to novel and target stimuli

Cited by 244 publications

References 43 publications

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

The dependence of P300 amplitude on gamma synchrony breaks down in schizophrenia

Stimulus context determines whether non-target stimuli are processed as task-relevant or distractor information

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