Age-related changes in responsiveness of various rat tissue lymphocytes to mitogens

Kaplan, Phyllis-Jean; Garvey, James E.

doi:10.1016/0165-2478(81)90067-5

Cited by 10 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, TC‐PTP −/− splenocytes had impaired responses to both mitogenic stimuli, suggesting that besides having an effect of B and T‐cell development, TC‐PTP may be involved in their function as well. It will be interesting to determine whether TC‐PTP −/− mice experience accelerated but normal age‐related thymic involution, given that both thymic involution and decreased ConA responsiveness of T cells are observed during the normal aging process (26, 27) as well as in TC‐PTP −/− mice, or whether the change in thymic size and cellularity is due to another pathological condition.…”

Section: The Knockout Mouse Model Of Tc‐ptpmentioning

confidence: 99%

T‐cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

Doody

Bourdeau

Tremblay

2009

Immunological Reviews

102

View full text Add to dashboard Cite

The immune system requires for its proper ontogeny, differentiation, and maintenance the function of several tyrosine kinases and adapters that create and modify tyrosine phosphorylation sites. Tyrosine phosphorylation is a crucial protein modification in immune cell signaling and can be reversed by protein tyrosine phosphatases (PTPs). Much progress has been made in identifying and understanding PTP function in the immune system. In this review, we present one of these proteins, named T-cell PTPs (TC-PTP) (gene name PTPN2), a classical, non-receptor PTP that is ubiquitously expressed with particularly high expression in hematopoietic tissues. TC-PTP is remarkable not only by the fact that it appears to influence most, if not all, cells involved in the development of the immune system, from stem cells to differentiated lineages, but also recent findings have positioned it at the core of several human diseases from autoimmune disease to cancer.

show abstract

Section: The Knockout Mouse Model Of Tc‐ptpmentioning

confidence: 99%