Age-related changes in nitric oxide content and nitric oxide synthase activity in senescence-accelerated mouse (SAMP8) brain

Yokoi, Isao; Inada, Kazunori; Habu, Hiroshi; Kabuto, Hideaki; Mori, Akitane; Ohyama, Hideki; Iwaya, Kazuo; Koyama, Shigeki; Nishijima, Yutaka; Nishijima, Katsumi

doi:10.1007/978-3-0348-7337-6_36

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Senescence-accelerated Mouse (Sam)1

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2008

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“…Akitane and Jiankang Liu hypothesized that one possible mechanism for accelerated aging may be an increase in oxidative stress in this animal model. They observed age-associated biochemical changes in the brain and liver, and suggested that the mechanism of senescence acceleration in SAM is related to ROS-induced damage [48,49]. Then, Akitane carried out an experiment to administer the spin-trapping agent N-tert-alpha-phenylbutylnitrone (PBN) to SAM, and found that PBN treated animals as compared with control sham injected animals revealed a remarkable extension of the mean life span in both male and female groups.…”

Section: Senescence-accelerated Mouse (Sam)mentioning

confidence: 99%