volume 5, issue 10, P725-740 2013
DOI: 10.18632/aging.100603
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Nicole Noren Hooten, Megan Fitzpatrick, William H. Wood, Supriyo De, Ngozi Ejiogu, Yongqing Zhang, Julie A. Mattison, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans

Abstract: microRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate gene expression by targeting specific mRNAs. Altered expression of circulating miRNAs have been associated with age-related diseases including cancer and cardiovascular disease. Although we and others have found an age-dependent decrease in miRNA expression in peripheral blood mononuclear cells (PBMCs), little is known about the role of circulating miRNAs in human aging. Here, we examined miRNA expression in human serum from young…

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