2013
DOI: 10.18632/aging.100603
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Age-related changes in microRNA levels in serum

Abstract: microRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate gene expression by targeting specific mRNAs. Altered expression of circulating miRNAs have been associated with age-related diseases including cancer and cardiovascular disease. Although we and others have found an age-dependent decrease in miRNA expression in peripheral blood mononuclear cells (PBMCs), little is known about the role of circulating miRNAs in human aging. Here, we examined miRNA expression in human serum from young… Show more

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Cited by 252 publications
(130 citation statements)
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“…1). Age‐related miRNA expression studies in whole blood (ElSharawy et al ., 2012), PBMCs (Noren Hooten et al ., 2010), and serum (Noren Hooten et al ., 2013; Zhang et al ., 2014) have similarly reported that the majority of age‐related miRNAs show decreased expression in older individuals.…”
Section: Resultsmentioning
confidence: 99%
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“…1). Age‐related miRNA expression studies in whole blood (ElSharawy et al ., 2012), PBMCs (Noren Hooten et al ., 2010), and serum (Noren Hooten et al ., 2013; Zhang et al ., 2014) have similarly reported that the majority of age‐related miRNAs show decreased expression in older individuals.…”
Section: Resultsmentioning
confidence: 99%
“…In comparison with previous age‐related miRNA expression studies (Noren Hooten et al ., 2010, 2013; ElSharawy et al ., 2012; Zhang et al ., 2014), our study included > 25 times as many participants ( N  = 5221 vs N  < 200) and a wide age range (24–92 years). As such, our study was well powered to investigate differential levels of miRNA expression in relation to age.…”
Section: Discussionmentioning
confidence: 99%
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“…Total RNA including miRNAs was isolated using the Absolutely RNA miRNA Kit (Agilent) and analyzed using the Agilent Mouse miRNA Microarray 15.0. Microarray was performed and analyzed as previously described (Noren Hooten et al ., 2013). Individual miRNAs with pairwise z‐test P value ≤ 0.05, absolute value of Z ratio ≥ 1.5, with fdr ≤ 0.3 were considered significantly changed.…”
Section: Methodsmentioning
confidence: 99%
“…Additionally, dicer loss‐of‐function mutations in Caenorhabditis elegans reduce lifespan and homeostatic stress responses (Mori et al ., 2012). We reported that miRNA levels decrease with advancing age in human peripheral blood mononuclear cells (PBMCs) and primate skeletal muscle, while others have found decreased levels of miRNAs with age in mouse brain and in C. elegans (Noren Hooten et al ., 2010, 2013; Smith‐Vikos & Slack, 2012; Mercken et al ., 2013). Given the conservation of miRNAs across species, and that a single miRNA can regulate C. elegans lifespan and predict the mortality of individual C. elegans (Smith‐Vikos & Slack, 2012), it is likely that miRNAs play an important role in regulating lifespan in humans and other species.…”
Section: Introductionmentioning
confidence: 99%