Age-related changes in interleukin production in BALB/cNNia and SJL/J mice and their modification after administration of foreign macromolecules

Gorczynski, Reginald M.; Dubiski, S.; Munder, P. G.; Cinader, B.; Westphal, Otto

doi:10.1016/0165-2478(93)90013-r

Cited by 21 publications

(28 citation statements)

References 14 publications

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“…These animals were not immunized and constitute a different mouse strain. Considering the latter, BALB/c mice tend to have a constant IL-2 production throughout the life span (Gorczynski et al 1993) whereas C57/BL6 mice present a reduced IL-2 production with ageing (Kubo and Cinader 1990;Wakikawa et al 1999). These different strain features could partially explain IL-2 secretion differences observed between studies.…”

Section: Discussionmentioning

confidence: 73%

Dehydroepiandrosterone Sulphate Enhances IgG and Interferon-Gamma Production During Immunization to Tuberculosis in Young But not Aged Mice

et al. 2006

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Ageing of the endocrine system (endocrinosenescence) has been closely related to immunosenescence. Dehydroepiandrosterone sulphate (DHEAS), a steroid hormone produced by the adrenals with reported enhancing immunomodulatory properties, consistently decline during ageing in parallel to detrimental increase in peripheral glucocorticoids. We investigated here the adjuvant effects of DHEAS during intraperitoneal immunization to Mycobacterium tuberculosis heat shock protein 70 (mycHSP70) in old (24 months) as well as young (3 months) BALB/c mice. Both young and old mice had significantly higher Immunoglobulin G (IgG) levels following immunization. Young mice co-immunized with mycHSP70-DHEAS presented an early increase in specific IgG levels and showed increased Interferon-gamma production compared to old mice. Also, T cells of immunized young animals were consistently more resistant to the immunosuppressive effects of glucocorticoids and to DHEAS. DHEAS was not effective in modulating antigen-specific T-cell proliferation, Interleukin-2 production or percentage of recent activated T-cell subsets (CD4 + CD69 + and CD8 + CD69 +). Our data further indicate mycHSP70 as a putative good antigen in vaccine to tuberculosis. Our data also suggest that DHEAS produced adjuvant effects upon humoral and some cellular immune responses of young, but not old mice and indicate that immunization with DHEAS is capable of changing T-cell responses to steroids.

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Section: Discussionmentioning

confidence: 73%

Dehydroepiandrosterone Sulphate Enhances IgG and Interferon-Gamma Production During Immunization to Tuberculosis in Young But not Aged Mice

et al. 2006

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“…Our earlier studies documented that the crude CLP described above could function in vivo by activating cytokine production from macrophages, and in particular could alter cytokine production from cells of aged mice in a manner, which produced a response more typical of younger isogeneic mice [8]. To assess whether ␥-Hb, in combination with CLP, could differentially alter cytokine production from LPS-stimulated macrophages of aged versus young mice, the following study was performed.…”

Section: Clp Lps and Hbγ-chain Interact Differentially In Inducing Cmentioning

confidence: 99%

“…Sheep fetal liver extract (hereafter referred to as CLP) was prepared at Clinique La Prairie (Montreux, Switzerland) as described in earlier reports [8]. Adult and fetal (cord blood) was obtained from human volunteers and from sheep, red cells washed twice in PBS, and the cell pellet lysed with one-fold volume of distilled sterile water.…”

Section: Preparation Of Sheep Fetal Liver Extract (Clp) and Fetal/adumentioning

confidence: 99%

Analysis of interaction of cloned human and/or sheep fetal hemoglobin γ-chain and LPS in augmenting induction of inflammatory cytokine production in vivo and in vitro

Gorczynski¹,

Alexander²,

Bessler³

et al. 2005

Immunology Letters

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“…PKC was partially purified by DE-52 chromatography and as sayed by the transfer o f [y-32P]ATP to type III-S lysine-rich histone as described [24]. All samples were assayed in triplicate under these conditions.…”

Section: Pkc Assaymentioning

confidence: 99%

Immunological Functions of Aged Human Monocytes

et al. 1995

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Aging is associated with an increased occurrence of infection and cancer, and, as people age, they begin to exhibit age-related immune deficiencies, collectively termed immunosenescence. To determine the effects of age on human monocytes, ‘aged monocytes’ (isolated from individuals > 65 years of age) were compared with ‘young monocytes’ (isolated from individuals -25 years of age) for their ability to be activated by lipopolysaccharide. Our results show that aged monocytes display a decrease in their cytotoxicity against tumor cells in vitro, a decrease in interleukin (IL1) secretion (although no decrease in IL1 precursor production was observed), a decrease in reactive oxygen and nitrogen intermediate (ROI/RNI) release, an increase in intracellular levels of cyclic adenosine monophosphate and a loss of protein kinase translocation. Therefore, aged monocytes present distinct characteristics of immunosenescence.

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Age-related changes in interleukin production in BALB/cNNia and SJL/J mice and their modification after administration of foreign macromolecules

Cited by 21 publications

References 14 publications

Dehydroepiandrosterone Sulphate Enhances IgG and Interferon-Gamma Production During Immunization to Tuberculosis in Young But not Aged Mice

Dehydroepiandrosterone Sulphate Enhances IgG and Interferon-Gamma Production During Immunization to Tuberculosis in Young But not Aged Mice

Analysis of interaction of cloned human and/or sheep fetal hemoglobin γ-chain and LPS in augmenting induction of inflammatory cytokine production in vivo and in vitro

Immunological Functions of Aged Human Monocytes

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