Age-Related Changes in Heart Rate during Copulatory Behavior of Male Rats

Terada, Misao; Wato, Seiko; Kromkhun, Pacharaporn; Hashimoto, Haruo; Taniguchi, Kazumi; Sakurai, Fujiro; Yokosuka, Makoto; Nagy, György; Saitô, Tôru

doi:10.1538/expanim.58.427

Cited by 8 publications

(3 citation statements)

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“…Consistent with this idea, sexual activity evokes HPA axis activation [53, 54] and the magnitude of the HPA response varies with degree of sexual experience [55, 56]. Additionally, sexual activity can also evoke increases in heart rate and blood pressure [57–61], and in neuronal activation [62, 63]. However, it is unclear whether palatable food intake evokes similar physiological stress activation, and whether this varies with familiarity with the palatable food.…”

Section: Introductionmentioning

confidence: 99%

Activation of physiological stress responses by a natural reward: Novel vs. repeated sucrose intake

Egan

Ulrich‐Lai

2015

Physiology & Behavior

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Pharmacological rewards, such as drugs of abuse, evoke physiological stress responses, including increased heart rate and blood pressure, and activation of the hypothalamic-pituitary-adrenal (HPA) axis. It is not clear to what extent the natural reward of palatable foods elicits similar physiological responses. In order to address this question, HPA axis hormones, heart rate, blood pressure and brain pCREB immunolabeling were assessed following novel and repeated sucrose exposure. Briefly, adult, male rats with ad libitum food and water were given either a single (day 1) or repeated (twice-daily for 14 days) brief (up to 30 minutes) exposure to a second drink bottle containing 4 ml of 30% sucrose drink vs. water (as a control for bottle presentation). Sucrose-fed rats drank more than water-fed on all days of exposure, as expected. On day 1 of exposure, heart rate, blood pressure, plasma corticosterone, and locomotion were markedly increased by presentation of the second drink bottle regardless of drink type. After repeated exposure (day 14), these responses habituated to similar extents regardless of drink type and pCREB immunolabeling in the hypothalamic paraventricular nucleus (PVN) also did not vary with drink type, whereas basolateral amygdala pCREB was increased by sucrose intake. Taken together, these data suggest that while sucrose is highly palatable, physiological stress responses were evoked principally by the drink presentation itself (e.g., an unfamiliar intervention by the investigators), as opposed to the palatability of the offered drink.

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Section: Introductionmentioning

confidence: 99%

Activation of physiological stress responses by a natural reward: Novel vs. repeated sucrose intake

Egan

Ulrich‐Lai

2015

Physiology & Behavior

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“…Studies on the external genitalia were also performed in reproductive physiology and biology for copulation (Terada et al 2009). In the field of toxicology and teratology, precise definition of developmental parameters has been required.…”

Section: Introductionmentioning

confidence: 99%

Systematic analyses of murine masculinization processes based on genital sex differentiation parameters

Suzuki

Yamada

2015

Dev Growth Differ

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Murine reproductive tissues of the external genitalia and perineum develop with remarkably distinctive characteristics in males and females. Although many researches on such mouse organ development have been reported, there are still limited parameters that evaluate the developmental sexual differences of external genitalia and perineum. Furthermore, elucidation of the recent developmental signals for the external genitalia and perineum requires up-to-date knowledge of gene functions in reproductive science. To promote researches on reproductive organ formation, establishment of parameters for the androgen-mediated formation of external genitalia and perineum is essential. In this study, we propose genital sex differentiation parameters (GSDP), a set of developmental parameters based on systematic three-dimensional tissue reconstruction and cumulative histological analyses. We define the sexual differences of external genitalia and perineum by GSDP through analyzing mouse models, androgen inhibitor-induced feminization experiments and Mafb mutant mouse with defective urethral differentiation. The urethral parameters displayed prominent reduction by the androgen inhibitor (finasteride) treatment. However, genital tubercle (GT) size parameters were not affected by such treatment. These results indicated that sensitivity to dihydrotestosterone was different between embryonic GT size and urethral formation. Furthermore, we evaluated the extent of urethral defects of Mafb mutant mice by GSDP. Thus, GSDP is a set of useful parameters to define the sexual differences during external genitalia and perineum development.

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“…Basic sexual behavior data are essential because patterns of sexual behavior vary with species. We have previously reported a change in heart rate (HR) in stallions and both young adult and aged male rats during copulation, as measured using a telemetry system, showing the function of the autonomic nervous system [4][5][6][7] and indicating that copulatory behavior increases the load on the circulatory system. However, in-depth research on physiological indices in the male dog during copulatory behavior has yet to be conducted.…”

Section: Introductionmentioning

confidence: 99%

Time‐dependent changes in cardiovascular function during copulatory behavior induced by the hand method in the male dog

Terada

Horii²,

Sato

et al. 2013

Reprod Medicine & Biology

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PurposeEjaculation in the male dog consists of three fractions. Observation of behavior and measurement of heart rate (HR), and plasma noradrenaline (NA) and adrenaline (Ad) concentrations were researched sequentially, and a fundamental examination of the features of sympathetic nerve activity during copulatory behavior induced by the hand method in the male dog was undertaken.MethodsWe investigated the breeding capability of male dogs. HR, plasma NA level and plasma Ad levels were measured during ejaculation induced by the hand method.ResultsHR was 125.8 ± 6.0 beats/min at rest, and peaked during mounting at 195.2 ± 8.2 beats/min. Moreover, HR at 3 min after the first fraction decreased to values similar to those at rest. Plasma NA and Ad concentrations during copulatory behavior induced by the hand method did not differ significantly from those at rest. However, although there was no significant difference, plasma NA concentration during ejaculation of the third fraction peaked at about 1.8 times the baseline value.ConclusionsIn the male dog, excitation of sympathetic nerves of long duration during erection of the penis and ejaculation is questionable. However, inhibition of sympathetic nerves and activation of parasympathetic nerves is thought to occur during erection of the penis and ejaculation.

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Age-Related Changes in Heart Rate during Copulatory Behavior of Male Rats

Cited by 8 publications

References 28 publications

Activation of physiological stress responses by a natural reward: Novel vs. repeated sucrose intake

Activation of physiological stress responses by a natural reward: Novel vs. repeated sucrose intake

Systematic analyses of murine masculinization processes based on genital sex differentiation parameters

Time‐dependent changes in cardiovascular function during copulatory behavior induced by the hand method in the male dog

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