Age-related changes in corneal and ocular higher-order wavefront aberrations

Amano, Shiro; Amano, Yuki; Yamagami, Satoru; Miyai, Takashi; Miyata, Kazunori; Samejima, Tomokazu; Oshika, Tetsuro

doi:10.1016/j.ajo.2004.01.005

Cited by 189 publications

(121 citation statements)

References 26 publications

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“…In this study, since primarily the central region of the double-pass LSF was examined, aberrations and diffraction likely had a dominant role in determining the LSF shape. The results of the current study indicate broadening of the Lorentzian fitted curve with age, corresponding to previous studies that have reported increased aberrations due to aging in normal subjects (Hammond et al, 2000;Artal et al, 2002;Brunette et al, 2003;Amano et al, 2004). Also, the width of the LSF depends on pupil size and has been reported to vary by 1.8 arc min for pupil diameters in the range of 4.9~6.6 mm (Campbell and Gubisch, 1966).…”

Section: Discussionsupporting

confidence: 61%

Representing the retinal line spread shape with mathematical functions

Yang

Wanek

Shahidi

2008

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To report a mathematical function that characterizes the double-pass line spread function (LSF) of the human eye. Determining analytical functions that represent the double-pass LSF is important because it allows modeling the optical performance of the eye. Methods: Optical section retinal images, generated in normal human eyes using a modified slit-lamp biomicroscope, were analyzed to derive the double-pass LSF by plotting the intensity distribution of laser light reflected/ scattered from the vitreoretinal interface. Three mathematical functions (Lorentzian, Gaussian, exponential) were fitted to the double-pass LSF and the root mean square error (RMSE) was calculated to provide a measure of the goodness of fit. Results: The Lorentzian function provided the best representation of the double-pass LSF of normal human eyes. The full width at half maximum (FWHM) of the Lorentzian fitted curve was positively correlated with age, indicating that the double-pass LSF broadens with age. Furthermore, the goodness of fit of the Lorentzian function was significantly better in younger subjects as compared with older subjects, suggesting that the fitted function to the double-pass LSF may vary according to age. Conclusion: The results demonstrate an age-related change in the double-pass LSF width and the goodness of fit of the Lorentzian function.

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Section: Discussionsupporting

confidence: 61%

Representing the retinal line spread shape with mathematical functions

Yang

Wanek

Shahidi

2008

J. Zhejiang Univ. Sci. B

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“…5,6 Therefore, the total ocular aberration increases with age, leading to deterioration of optical quality in older subjects. [7][8][9][10] When the crystalline lens is replaced by an intraocular lens (IOL) in cataract surgery, further changes may occur. It has been shown that ocular higher-order aberration in pseudophakic eyes is comparable with that in phakic eyes of subjects of the same age.…”

Section: Introductionmentioning

confidence: 99%

Correlation of higher-order wavefront aberrations with visual function in pseudophakic eyes

Hayashi

Yoshida

Hayashi

2007

Eye

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Aim To study the correlation between higher-order wavefront aberrations and visual function in eyes with a spherical monofocal intraocular lens (IOL), and to see if the aberrations differ between eyes that received different types of IOLs. Methods One hundred forty-eight eyes of 148 patients who underwent phacoemulsification and implantation of one of five types of acrylic IOL were enrolled. At 1 month after surgery, ocular aberrations were measured using a Hartmann-Shack aberrometer and corneal aberrations were measured using videokeratography. In addition, the aberration of internal optics was determined by subtracting the corneal aberration from the ocular aberration. These aberrations were correlated with visual acuity and with contrast visual acuity under both photopic and mesopic conditions. Results Ocular, corneal, and internal optic aberrations (total aberration, coma, and spherical aberration) were all correlated significantly with visual acuity, as well as with photopic and mesopic contrast visual acuity. The associations between internal optic aberrations and visual function tended to be stronger than were those of corneal aberrations. Furthermore, ocular aberrations differed significantly between eyes with the five different IOLs (Pp0.0078). Specifically, the internal optic spherical aberration was markedly significantly different between eyes (P ¼ 0.0142), and the corneal coma showed a marginally significant difference (P ¼ 0.0421). Conclusion Ocular, corneal, and internal optic higher-order wavefront aberrations are correlated significantly with visual function in eyes with a spherical monofocal IOL. The spherical aberration of the internal optics and coma of the cornea vary between eyes with different types of IOL.

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“…[1][2][3] Thus far, numerous fundamental studies on ocular wavefront aberrations have been carried out, and some of them have elucidated that HOAs increase with age. [4][5][6] However, most studies have been conducted in adults and the information on HOAs in a pediatric population is still very limited. [6][7][8][9] The influence of accommodation on HOAs has also been investigated, 2,[10][11][12][13][14] and previous studies have shown that HOAs change with increasing levels of accommodation.…”

Section: Introductionmentioning

confidence: 99%

Influence of cycloplegia with topical cyclopentolate on higher-order aberrations in myopic children

Hiraoka

Nakamura

Ogata

et al. 2014

Eye

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Purpose To investigate the influence of cycloplegia with topical cyclopentolate on wavefront aberrations in myopic children. Design This is a prospective, comparative study. Methods Twenty-eight myopic children with a mean age of 7.25±2.55 were enrolled in this study. We evaluated refraction and wavefront aberrations before and after cycloplegia with 1% cyclopentolate hydrochloride. Ocular and corneal aberrations were simultaneously measured and compared with each other. Individual Zernike components were also analyzed up to the sixth order. All these parameters were compared before and after cycloplegia. Results Ocular higher-order aberrations (HOAs) significantly increased after cycloplegia (P ¼ 0.012 for spherical-like and P ¼ 0.015 for total HOAs). Corneal HOAs did not change after cycloplegia. When corneal and ocular HOAs were compared, the ocular HOAs were significantly smaller than the corneal HOAs in spherical-like aberrations (Po0.001) and total HOAs (P ¼ 0.006). As for individual Zernike components, ocular aberration generally showed smaller or equivalent values in comparison with corneal aberration. In addition, each Zernike component showed a large standard deviation. Conclusions Internal optics compensates for corneal HOAs in myopic children, and paralysis of tonic accommodation with cyclopentolate considerably affects ocular HOAs. However, inter-individual variation in each Zernike component is quite large in myopic children.

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Age-related changes in corneal and ocular higher-order wavefront aberrations

Cited by 189 publications

References 26 publications

Representing the retinal line spread shape with mathematical functions

Representing the retinal line spread shape with mathematical functions

Correlation of higher-order wavefront aberrations with visual function in pseudophakic eyes

Influence of cycloplegia with topical cyclopentolate on higher-order aberrations in myopic children

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