Age-Related Changes in Control of Blood Pressure and Heart Rate During Sleep in the Rat

The Influence of Aging on Pharyngeal Collapsibility During Sleep

“…27 Impairment in the negative pressure reflex with aging may reflect a generalized deterioration in reflexes including reduced responses to noxious stimuli, reduced deep tendon reflexes, and poorer control of arterial BP and heart rate during sleep. 28,29 The precise events leading to arousal and apnea termination are still not well understood. After airway occlusion, respiratory stimulation from falling PO 2 and rising PCO 2 , and increasing intrathoracic negative pressure appear to work in combination to produce arousal.…”

Physiological Sleep‐dependent Changes in Arterial Blood Pressure: Central Autonomic Commands and Baroreflex Control

“…However, in cats studied 1 month after surgery, HR increases on passing from NREMS to REMS, as occurs with ABP 54 . There are also discrepancies among studies on rats, with an increase, 56,61 a decrease 25,34,37,49 or no significant change 23,24 in HR being reported during REMS. Similarly, in different inbred mouse strains, an increase, a decrease or no significant change in the mean value of HR has been observed during REMS without any apparent relationship with changes in ABP 50 …”

Systemic Homeostasis and Poikilostasis in Sleep

“…A decrease in heart rate was observed in cats early after surgery (Mancia et al, 1971) and an increase after a prolonged recovery from surgery (Sei et al, 1989). In rats, an increase (Sei and Morita, 1996b;Sei et al, 2002), a decrease (Miki et al, 2003(Miki et al, , 2004Nagura et al, 2004;Yoshimoto et al, 2004) and a non-significant change Zoccoli et al, 2001) in heart rate were reported. In rabbits (Fig.…”