Age-Related Changes in Central and Peripheral Corneal Thickness

Rüfer, Florian; Schröder, Arne; Bader, Christine; Erb, Carl

doi:10.1097/01.ico.0000240095.95067.3f

Cited by 53 publications

(18 citation statements)

References 27 publications

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“…9,14 Conversely, collagen deposition and collagen fibril diameter have been shown to increase with age, suggesting that age-related biomechanical adaptations are likely to be complex and multilayered. In terms of corneal thickness (epithelium plus stroma), available literature has described a negative 17,18 as well as positive 19 correlation between central corneal thickness and age. Nonetheless, it is difficult to ascertain whether these changes are due to the epithelium, stroma, or a combination of both.…”

Section: Discussionmentioning

confidence: 99%

<p>Wide Stromal Mapping Using an Anterior Segment Optical Coherence Tomography</p>

Hashmani¹,

Hashmani²,

Asghar³

et al. 2020

OPTH

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Purpose: To quantify and assess the reproducibility of the corneal stromal thickness profiles captured by the SD-OCT. Secondly, we correlated the zonal thicknesses to the age, gender and axial length. Methods: We included 227 normal eyes of 227 patients with a maximum hypermetropia of +5 and myopia of-6 diopters (D). Subjects with an intraocular pressure exceeding 22 mm Hg, evidence of cataract formation, history of ophthalmic surgery or disease were excluded. Lastly, reproducibility was evaluated in a subset of 50 participants by means of an identical scan protocol repeated by 2 different OCT operators. Results: Stromal values were consistently thicker in the peripheral cornea (p<0.001). Age was negatively correlated with approximately every sector of the stroma with notable exceptions of the center (r=0.117, p=0.088) and the superior inner (r=0.057, 0.409), middle (r=0.086, p=0.209) and outer locations (r=0.120, p=0.079). There was no statistical significance in most sectors when looking at the axial length, gender and K1/K2. This method was highly reproducible in terms of both the ICC and COV. Conclusion: Corneal stromal mapping is highly reproducible and shows a negative correlation to age. Additionally, the periphery of the stroma is consistently thicker to the center. Other variables like gender and axial length show no relationship to the corneal stroma.

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Section: Discussionmentioning

confidence: 99%

<p>Wide Stromal Mapping Using an Anterior Segment Optical Coherence Tomography</p>

Hashmani¹,

Hashmani²,

Asghar³

et al. 2020

OPTH

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“…Recent work highlights the directional specificity of the cornea and demonstrates that a corneal transplant is a bioactive scaffold that has a distinct orientation and regional densities 2, 19 . Structural collagen in the human eye provides stability to the cornea, maintains intra-ocular pressure, and affects the degree of corneal astigmatism present 20, 21 .…”

Section: Discussionmentioning

confidence: 99%

“…Structural collagen in the human eye provides stability to the cornea, maintains intra-ocular pressure, and affects the degree of corneal astigmatism present 20, 21 . The preferential alignment of corneal collagen and variations in regional density and thickness has been shown to have physiological importance in stability and function, and maintaining alignment during transplantation may facilitate graft healing, survival or post-surgical refraction 19,20,22–24 . A technical drawback to testing this hypothesis has been that Eye Banks would need to mark the orientation of every cornea prior to removal from the globe, not only those corneas destined for corneal transplants.…”

Section: Discussionmentioning

confidence: 99%

Identifying the Palisades of Vogt in Human Ex Vivo Tissue

et al. 2016

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Purpose The Palisades of Vogt (POV) constitute the corneal epithelial stem cell niche, but identification of this region in ex-vivo tissue is difficult. Here we introduce a simple, direct method of identifying the POV in unsectioned, ex-vivo human tissue. Methods Twenty-two eyes were studied, four whole and eighteen rims. Orientation of whole eyes was determined and the eyes were marked to maintain their cardinal orientation prior to dissection. Samples were imaged with brightfield, linearly polarized light and transmitted circularly polarized light (CPL) and optical coherence tomography (OCT) volumes were acquired in all twelve clock hours around the limbus. Five samples were also fluorescently labeled to identify the epithelial basement membrane, and whole mounts were imaged with laser scanning confocal microscopy. Images were compared to confirm that the structures visible with polarized light were POV. Results Under CPL the POV presented as amber radial ridges visible in the superior and inferior regions of the tissue. Identification of POV was confirmed by correlating the structures seen under CPL, OCT and laser-scanning confocal microscopy. Conclusions CPL can be used to quickly identify POV regions in donor tissue. This technique can assist in targeted harvesting of stem cell regions for research and tissue for limbal transplant.

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“…Measurements of CCT, ACV and ACD can be done by using ultrasonic methods but these methods are cornea contact and may lead to superficial corneal lesions and transmission of infections. 6 Non-contact methods such as optical coherence tomography (OCT), Scheimpflug topography systems and slit scanning technologies have been used widely. [7][8][9] The Galilei Dual Scheimpflug Analyzer is one of the Scheimpflug topography system which is based on a revolving dual-channel Scheimpflug camera and a Placido disk.…”

Section: Ori̇ji̇nal Araştirma Original Researchmentioning

confidence: 99%

The Assessment of Age-Related Changes in Anterior Segment Parameters Measured by Dual Scheimpflug Analyzer

Aksoy¹,

Çakır²,

Özmen³

et al. 2020

Turkiye Klinikleri J Ophthalmol

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The aim of this study was to investigate the changes according to age in anterior segment parameters measured by Galilei Dual Scheimpflug Analyzer. Material and Methods: Healthy subjects were recruited and classified into seven groups according to age. Group 1 consisted of subjects whose ages ranged between 5 and 10 years. Group 2, 3, 4, 5, 6, 7 consisted of subjects who were in their second, third, forth, fifth, sixth and seventh decades, respectively. After a detailed examination, anterior segment parameters were assessed by using Galilei Dual Scheimpflug Analyzer. The following parameters were obtained from topographic and pachymetric maps for analysis: anterior chamber angle (ACA), anterior chamber depth (ACD), anterior chamber volume (ACV), central corneal thickness (CCT), pupil diameter (PD) and corneal horizontal diameter (CHD). Statistical analysis was performed by using SPSS for Windows version 23.0. Results: The age of subjects ranged between 5 and 67 years. Of 229 subjects, 152 (66.4%) were female and 77 (33.6%) were male. The decrease in CCT, CHD, PD, ACD and ACA with age was statistically significant and a negative correlation was present (p=0.000). Except Group 1, the decline in ACV by increasing age was statistically significant and a negative correlation was present [r (458) =-0.34. p=0.000]. Conclusion: All anterior segment parameters except mean ACV measured by Galilei Dual Scheimpflug Analyzer were found to decline with age and mean ACD achieved to adult size till the beginning of the second decade.

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Age-Related Changes in Central and Peripheral Corneal Thickness

Abstract: The normal values presented here are a suitable reference basis for future studies in whites. Peripheral corneal thickness is asymmetric and seems to undergo age-related anatomic changes. This information should be considered when planning penetrating keratoplasty and refractive surgery.

Cited by 53 publications

References 27 publications

<p>Wide Stromal Mapping Using an Anterior Segment Optical Coherence Tomography</p>

<p>Wide Stromal Mapping Using an Anterior Segment Optical Coherence Tomography</p>

Identifying the Palisades of Vogt in Human Ex Vivo Tissue

The Assessment of Age-Related Changes in Anterior Segment Parameters Measured by Dual Scheimpflug Analyzer

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