Age-related changes in brain biogenic monoamines and monoamine oxidase

Stancheva, S; Petkov, V.; Alova, L

doi:10.1016/0306-3623(87)90097-8

Cited by 19 publications

(7 citation statements)

References 13 publications

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“…The significant decrease in brain serotonin levels and loss of diurnal serotonin differences in 12, 18 and 24 months obtained in present study could be responsible for the altered wheel running activity, feeding, drinking and core temperature in old rats with higher standard error and decreased melatonin synthesis and its out flow reported by earlier workers (Li and Satinoff 1995;Mishima et al 2001). In addition the age-related changes in morphology of serotonergic neurons in rat brain stem nuclei (Lolova 1996), frontal cortex, striatum, hypothalamus (Petkov et al 1987) and in various brain regions (Timiras et al 1984), decline in transport and uptake of tryptophan (Tang and Melethil 1995), melatonin and norepinephrine levels (Cardinali et al 2002) and MT 1 melatonin receptor in SCN (Wu et al 2007). The age induced decreased serotonin levels could also be responsible for age related increased MAO-B levels and neurodegeneration (Toussaint et al 2000).…”

Section: Discussionmentioning

confidence: 96%

Daily serotonin rhythms in rat brain during postnatal development and aging

Jagota

Kalyani

2008

Biogerontology

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Aging is characterized by progressive decline in most physiological functions. The age-related sleep disturbances have been attributed to disturbances of circadian function. Neurotransmitter serotonin plays important role in the photic and non-photic regulation of circadian rhythms and is a precursor of melatonin, an internal zeitgeber. To understand the age induced changes in the functional integrity of circadian system, we studied daily serotonin rhythms in brain by measuring serotonin levels at variable time points in wide range of age groups such as 15 days, 1, 2, 3 (adult), 4, 6, 9, 12, 18 and 24-months old male Wistar rats. Animals were maintained under light-dark conditions (LD 12:12), 2 weeks prior to experiment. We report here, mean serotonin levels over 24 h period in brain is highest at 3 months and daily serotonin rhythmicity reliably begins at 3 months and disintegrates at middle age and beyond. The age induced changes in daily serotonin rhythmicity in brain obtained in present study will be a step towards understanding age induced disorders of circadian function.

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Section: Discussionmentioning

confidence: 96%

Daily serotonin rhythms in rat brain during postnatal development and aging

Jagota

Kalyani

2008

Biogerontology

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“…An impairment of baroreceptor reflex sensitivity occurs during ageing in humans (Giannattasio et al 1994) and in rats (Tanabe and Bufiag 1989). Catecholamine content and turnover studies in the rat have shown hypothalamic noradrenaline to be reduced (Simpkins 1984;Roubein et al 1986;Reymond et al 1989) or unchanged (Carfagna et al 1985;Petkov et al 1987;Huguet et al 1993;Rodriguez-Gdmez et al 1995) with advanced age. Reduced concentrations of the noradrenaline precursor, dopamine, have been reported in specific brain regions including the hypothalamus (Simpkins 1984;Carfagna et al 1985;Reymond et al 1989), median eminence and striatum (Demarest et al 1980) of aged rats.…”

Section: Introductionmentioning

confidence: 99%

Altered in vivo catecholamine release in the hypothalamic paraventricular nucleus of the aged rat

Hastings

Pavia

Morris

1996

Naunyn-Schmiedeberg's Arch Pharmacol

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The effect of age on basal and stimulated noradrenaline release in the hypothalamic paraventricular nucleus (PVN) of the rat was examined by in vivo microdialysis. Microdialysis probes were inserted into the PVN of 3 and 18 month old anaesthetised Sprague Dawley rats and perfused with a modified Ringer solution. Following four basal 30-min collections, transmitter release was stimulated by perfusion with 100 mM potassium for one collection. After re-equilibration, blood pressure was raised 60 mmHg for 30 min by phenylephrine infusion (1-1.3 mg/kg) then a 2-h recovery period followed. Dialysate collections were injected directly onto a reverse phase HPLC-ECD (HPLC with electrochemical detection). Basal extracellular noradrenaline concentrations were found to be similar in adult and old animals. Basal dihydroxyphenylacetic acid (DOPAC) concentrations were significantly greater in old compared to adult rats (P < 0.05). Potassium depolarisation induced a significant increase in noradrenaline concentrations in both age groups (P < 0.001), however the noradrenaline response to potassium stimulation was significantly reduced in the aged rats (P < 0.05). Potassium-induced decreases in DOPAC and homovanillic acid (HVA) concentrations were seen in both age groups. Following phenylephrine infusion, a modest delayed reduction in noradrenaline levels, which failed to reach statistical significance, was seen. Phenylephrine-induced hypertension was associated with decreased DOPAC and HVA concentrations in adult (P < 0.05) and old (P < 0.05) rats, respectively. These results indicate that ageing is associated with changes in dopaminergic and noradrenergic activity in the PVN of the rat. A reduction in noradrenaline response to maximal stimulation induced by potassium depolarisation was observed with ageing. The alteration in the activity of the catecholaminergic pathways to the PVN induced by phenylephrine infusion appears to be age dependent.

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“…The significant decrease in SCN serotonin levels and loss of serotonin rhythmicity in 12, 18 and 24 months old rats obtained in present study is in agreement with age induced changes reported by some workers such as the altered wheel running activity, feeding, drinking and core temperature in old rats with higher standard error and decreased melatonin synthesis and its out flow (Li and Satinoff 1995;Mishima et al 2001). In addition the age-related changes in morphology of serotonergic neurons in rat brain stem nuclei (Lolova 1996), frontal cortex, striatum, hypothalamus (Petkov et al 1987) and in various brain regions (Timiras et al 1984) were reported earlier.…”

Section: Discussionmentioning

confidence: 87%

Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male Wistar rat

Jagota

Kalyani

2009

Biogerontology

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The decline in physiological functions with aging may affect the ability of the SCN, the biological clock, circadian pacemaker to transmit rhythmic information to other neural target sites, and thereby modify the expression of biological rhythms resulting in circadian disorders. Neurotransmitter serotonin plays important role in the photic and non-photic regulation of circadian rhythms and is a precursor of neurohormone melatonin, an internal zeitgeber. To assess effects of aging on the functional integrity of circadian system, we studied daily serotonin rhythms in the SCN by measuring serotonin levels at variable time points in wide range of age groups such as 15 days, 1, 2, 3 (adult), 4, 6, 9, 12, 18 and 24 months old male wistar rats. Animals were maintained in light-dark conditions (LD; 12:12) two weeks prior to experiment. We report here that in 15 days, 1 and 2 months old rat SCN the mean serotonin level is low and daily serotonin rhythm is just beginning; at 3, 4 and 6 months, serotonin levels and rhythms are robust and at 9, 12, 18 and 24 months mean serotonin levels are low again and rhythm is becoming more disrupted. Previous studies have shown the 5-HT rhythmicity was established by 3 month in rat brain but disintegrated by 6 months of age. As melatonin, an endogenous synchronizer and an antiaging agent, declines with aging, the effects of exogenous melatonin administration on serotonin rhythmicity in SCN in 3, 6, 9 and 24 months old rats were studied to assess effects of aging on responsiveness to melatonin. Our studies indicated an age related loss of sensitivity to melatonin in the restoration of age induced changes in SCN serotonin amplitude and rhythmicity.

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Age-related changes in brain biogenic monoamines and monoamine oxidase

Cited by 19 publications

References 13 publications

Daily serotonin rhythms in rat brain during postnatal development and aging

Daily serotonin rhythms in rat brain during postnatal development and aging

Altered in vivo catecholamine release in the hypothalamic paraventricular nucleus of the aged rat

Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male Wistar rat

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