Age‐related changes in bladder function with altered angiotensin II receptor mechanisms in rats

Mori, Kenichi; Noguchi, Mitsuru; Tobu, Shohei; Sato, Fuminori; Mimata, Hiromitsu; Tyagi, Pradeep; Chancellor, Michael B.; Yoshimura, Naoki

doi:10.1002/nau.22849

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Angiotensin 2 receptor is a vasoconstrictor reportedly involved in tissue remodeling associated with inflammation and fibrosis in the bladder wall. 19 Adrenomedullin has a vasodilatory effect on smooth muscles with nitric oxide and is considered to be involved in detrusor instability, angiogenesis, and cell proliferation. 20 The increased urinary level of adrenomedullin in patients with cystitis has been reported, 21 which could be related to the expressions of UPK1B and CST6, which may, in turn, involve in mucosal permeability and protective function.…”

Section: Discussionmentioning

confidence: 99%

Candidate genes involved in the defunctionalization and refunctionalization of the urinary bladder induced by bladder anuria and reperfusion

Kisou

Inoue

Nishijima

et al. 2020

Neurourology and Urodynamics

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Aims We develop a novel rabbit urinary diversion model of bladder defunctionalization due to bladder anuria followed by refunctionalization due to urine reperfusion to investigate the molecular biological background. To validate the results, we used reverse transcription‐polymerase chain reaction (RT‐PCR) to analyze human specimens from defunctionalized bladders in patients receiving dialysis before kidney transplantation. Methods Female rabbits were divided into three groups: control, defunctionalized, and refunctionalized. The bilateral ureters were anastomosed to vagina in the defunctionalized and refunctionalized groups at 0 weeks. In the refunctionalized group, the unilateral ureter was reanastomosed to the bladder at 8 weeks. Results The capacity and compliance of the rabbit bladder in the refunctionalized group were significantly lower than those in the control group at 8 weeks and higher than those in the defunctionalized group at 14 weeks. The significant downregulation of IGFBP2, UPK1B, and CST6 in the defunctionalized group compared with that in the control groups, and the significant downregulation of AGTR2 in the refunctionalized group compared with that in the defunctionalized group in the rabbit bladder‐muscle DNA microarray were validated by RT‐PCR. Human bladder muscle indicated significant downregulation of UPK1B and CST6 and significant downregulation of IGFBP2 in the defunctionalized group, which is consistent with both rabbit bladder‐muscle DNA microarray and rabbit bladder RT‐PCR results. Conclusions The present study using novel model of bladder defunctionalization followed by refunctionalization indicated the consistent downregulation of UPK1B and CST6 in muscle and the consistent downregulation of IGFBP2 in mucosa in process of bladder defunctionalization, which was validated by human specimens.

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Section: Discussionmentioning

confidence: 99%

Candidate genes involved in the defunctionalization and refunctionalization of the urinary bladder induced by bladder anuria and reperfusion

Kisou

Inoue

Nishijima

et al. 2020

Neurourology and Urodynamics

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“…A idade -é um dos grandes fatores de risco para LUTS 46 , com alterações de sinalização purinérgica (ATP), com diminuição da sinalização colinérgica 47,48 , com alterações no funcionamento do detrusor, como bexiga hiperativa, que é a causa de incontinência mais comum nos idosos 42 .…”

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Obstrução Infravesical em Homens com Sintomas do Trato Urinário Inferior Correlation of tools for objective evaluation of infravesical obstruction of men with lower urinary tract symptoms CAMPINAS 2019 ORESTES MAZZARIOL JUNIOR Correlação de Ferramentas não invasivas na Avaliação da Obstrução Infravesical em Homens com Sintomas do Trato Urinário Inferior Correlation of tools for objective evaluation of infravesical obstruction of men with lower urinary tract symptoms Tese de Doutorado apresentada à Faculdade de Ciências Médicas da Universidade Estadual de Campinas como parte dos requisitos exigidos para a obtenção do Título de Doutor em Ciências.

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Addressing challenges in underactive bladder: recommendations and insights from the Congress on Underactive Bladder (CURE-UAB)

et al. 2017

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Underactive bladder (UAB) is an expanding troublesome health issue, exerting a major influence on the health and independence of older people with a disproportionally low level of attention received. The 2nd International Congress on Underactive Bladder (CURE-UAB 2) convened in Denver, CO on December 3 and 4, 2015, and comprised of top clinicians, scientists, and other stakeholders to address the challenges in UAB. A series of workshops aimed to define UAB and its phenotype, define detrusor underactivity (DU) and create a subtyping of DU, evaluate existing animal models for DU, and lastly to establish research priorities for UAB.

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Age‐related changes in bladder function with altered angiotensin II receptor mechanisms in rats

Cited by 6 publications

References 25 publications

Candidate genes involved in the defunctionalization and refunctionalization of the urinary bladder induced by bladder anuria and reperfusion

Candidate genes involved in the defunctionalization and refunctionalization of the urinary bladder induced by bladder anuria and reperfusion

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Addressing challenges in underactive bladder: recommendations and insights from the Congress on Underactive Bladder (CURE-UAB)

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