Age‐related changes in biochemical and hematologic variables inBorzoi andBeagle puppies from birth to 8 weeks

Abstract

Clinicians should be aware of temporal changes in biochemical and hematologic values for puppies during the first 2 months of life to avoid misinterpretation of results.

Background Data for Hematological and Blood Chemical Examinations in Juvenile Beagles

“…It is known that the values of hematological and blood chemical parameters in dogs vary remarkably with growth [5], and the results obtained in the present study were roughly similar to those reported in previous papers [1,[3][4][5]. In 2012, rosset et al reported age-related changes in biochemical and hematologic variables in borzoi and beagle puppies from birth to 8 weeks [4], and they stressed that clinicians should be aware of temporal changes in biochemical and hematologic values for puppies during the first 2 months of life to avoid misinterpretation of results [4]. Toxicologists also have to be careful when they evaluate the results of hematological and blood chemical examinations.…”

“…however, physiological background data in juvenile dogs are still insufficient compared with those in juvenile rats. although some information about age-related changes in hematology and blood chemistry is available in dogs [1,[3][4][5], there are only a few reports that have attempted to summarize hematological and blood chemical data in juvenile beagle dogs used as control animals in toxicity studies conducted under controlled conditions. Therefore, as the first step to get useful historical background data in normal juvenile beagle dogs, this study was carried out to summarize the data on hematology and blood chemistry obtained from toxicity studies conducted in our laboratory and to compare them with those in adult beagle dogs.…”

Nontraditional Applications in Clinical Pathology

“…Erythrocyte values usually reach adult values around sexual maturity in animals (Chandler 1992). In Borzoi and Beagle puppies, HCT declines immediately after birth until week 6, then increases to adult levels by week 8 (Rosset et al 2012).…”

“…Lower serum creatinine concentrations in young puppies may be attributed to their lower muscle mass (Rosset et al 2012). Serum concentrations of calcium (total and unbound), phosphorus, magnesium, and ALP are affected by skeletal system development.…”

“…Hepatic maturity is reached quite early in life, that is, 5 to 8 weeks in dogs, but young animals typically have lower serum albumin concentrations and lower glycogen stores that make them susceptible to hypoglycemia (Johnston, Kustritz, and Olson 2010;Rosset et al 2012). The development of the renal system may be associated with lower GFR in young animals in comparison to adults.…”