Age-related changes in apolipoprotein A-I expression

Shah, Gul N.; Wong, Norman C.; Mooradian, Arshag D.

doi:10.1016/0005-2760(95)00174-3

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…Another study in Chinese population also identified that serum apoA1 enhanced greatly with aging, while it decreased gently after 70 years old [42], and. in an in vivo study, the expression of ApoA1 gene influenced by age was reported [41]. However, transcriptional rate of the ApoAl gene and synthesis of hepatic ApoA l protein were decreased with age.…”

Section: Discussionmentioning

confidence: 94%

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Profiling Plasma Peptides for the Identification of Potential Ageing Biomarkers in Chinese Han Adults

Huang

Wang

et al. 2012

PLoS ONE

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Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.

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Section: Discussionmentioning

confidence: 94%

“…Plasma ApoA1 protein has been reported to significantly increase with age [41]. As a major protein component of high density lipoprotein (HDL) in plasma, the level of ApoA1 is positively associated with HDL cholesterol (HDL-C) levels and it is one of the indicators of cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

Profiling Plasma Peptides for the Identification of Potential Ageing Biomarkers in Chinese Han Adults

Huang

Wang

et al. 2012

PLoS ONE

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“…Thus, insulin resistance and hyperinsulinemia induced with a high-fructose diet in rats is associated with increased apo A-I levels (56). Similarly, aging in rats is associated with increased expression of apo A-I, although it is accompanied with insulin resistance (57).…”

Section: Effect Of Insulin Resistance On Apo A-i Expressionmentioning

confidence: 99%

Transcriptional Control of Apolipoprotein A-I Gene Expression in Diabetes

2004

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Cardiovascular disease continues to be the leading cause of mortality in diabetes. One of the factors contributing to the increased risk is the high prevalence rate of low plasma concentrations of HDL cholesterol. Multiple potential mechanisms account for the cardioprotective effects of HDL and its main protein apolipoprotein (apo) A-I. The reduced plasma concentrations of HDL could be the result of increased fractional clearance of HDL and reduced expression of apo A-I. In animal models of diabetes and in cell cultures treated with high concentrations of glucose, apo A-I expression is reduced. In this review we will discuss the alterations in transcriptional control of apo A-I in diabetes. The role of select nutritional and hormonal alterations commonly found in diabetes will be reviewed. Specifically, we will review the literature on the effect of hyperglycemia, hypoinsulinemia, and ketoacidosis, as well as the role of various mediators of insulin resistance, such as fatty acids, cytokines, and prostanoids, on apo A-I promoter activity. Identifying the mechanisms that modulate apo A-I gene expression will aid in the new development of therapeutic agents that increase plasma apo A-I and HDL concentrations.

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“…The absorbance of bands was analyzed after background subtraction. The reproducibility of the apoA-I quantitation was established with gels loaded with different amounts of authentic apoA-I [24,25].…”

Section: Western Blot Analysismentioning

confidence: 99%