Age-related change in neural processing of time-dependent stimulus features

Kisley, Michael A.; Davalos, Deana B.; Engleman, Laura L.; Guinther, Paul M.; Davis, Hasker P.

doi:10.1016/j.cogbrainres.2005.09.014

Cited by 52 publications

(33 citation statements)

References 120 publications

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“…Smaller amplitude MMNs have been observed in patients with multiple sclerosis (Jung et al 2006; Santos et al 2006) Parkinson’s disease (Pekkonen et al 1995; Brønnick et al 2010), and in elderly participants with dementia compared to healthy normal elderly controls (Schroeder et al 1995; Mowszowski et al 2012). Somewhat smaller MMNs have been found in normal, healthy, elderly participants compared to younger controls (Kisley et al 2005; Foster et al 2013) but not to the extent found for clinical disorders such as those individuals with dementia. Conversely, there is indication that in patients with Alzheimer’s disease, intact auditory processing is indexed by MMN relative to attention-dependent processing (Gaeta et al 1999; Vecchio and Määttä 2011).…”

Section: What Is the Mmn?mentioning

confidence: 83%

Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction

et al. 2014

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Cognition is often affected in a variety of neuropsychiatric, neurological, and neurodevelopmental disorders. The neural discriminative response, reflected in mismatch negativity (MMN) and its magnetoencephalographic equivalent (MMNm), has been used as a tool to study a variety of disorders involving auditory cognition. MMN/MMNm is an involuntary brain response to auditory change or, more generally, to pattern regularity violation. For a number of disorders, MMN/MMNm amplitude to sound deviance has been shown to be attenuated or the peak-latency of the component prolonged compared to controls. This general finding suggests that while not serving as a specific marker to any particular disorder, MMN may be useful for understanding factors of cognition in various disorders, and has potential to serve as an indicator of risk. This review presents a brief history of the MMN, followed by a description of how MMN has been used to index auditory processing capability in a range of neuropsychiatric, neurological, and neurodevelopmental disorders. Finally, we suggest future directions for research to further enhance our understanding of the neural substrate of deviance detection that could lead to improvements in the use of MMN as a clinical tool.

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Section: What Is the Mmn?mentioning

confidence: 83%

Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction

et al. 2014

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“…Numerous cross-sectional studies of age effects on MMN in healthy individuals (Cooper et al, 2006, Czigler et al, 1992, Kisley et al, 2005, Pekkonen et al, 1996, Woods, 1992) indicate an age-related diminution of MMN, although there is evidence that the degree of this decline depends on stimulus parameters (Pekkonen, 2000, Todd et al, 2008). In contrast, the natural history of MMN amplitude across schizophrenia patients’ lifespan and stage of illness is not well understood.…”

Section: Introductionmentioning

confidence: 99%

The relationship between preattentive sensory processing deficits and age in schizophrenia patients

Kiang

Braff

Sprock

et al. 2009

Clinical Neurophysiology

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Objective-Auditory mismatch negativity (MMN) and P3a index preattentive detection of rare stimuli. Their amplitudes normally decrease with age. Previous studies have reported generally smaller than normal MMN and P3a in schizophrenia patients. We aimed to further characterize the course of these deficits over schizophrenia patients' lifespan.Methods-In 253 schizophrenia patients and 147 normal comparison participants (NCPs) encompassing a wide age range (18-65), event-related potentials were recorded while participants watched a silent video and were presented binaurally with 1-kHz tones 500 ms apart, including standards (P=.90, 50-ms duration) and deviants (P=0.10, 100-ms).Results-Over the entire age range, MMN and P3a were smaller in schizophrenia patients than NCPs. MMN amplitude declined with age in both groups, though slightly less steeply in schizophrenia patients than NCPs. P3a amplitude declined with age in NCPs but not in schizophrenia patients.Conclusions-In our cohort of schizophrenia patients, MMN and P3a deficits were already present at the youngest ages. MMN declined further with age, whereas P3a amplitude remained stable.Significance-This knowledge about how MMN and P3a amplitudes vary with age in schizophrenia patients compared to NCPs can help improve the utility of these indices as clinical endophenotypes or biomarkers.

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“…Nonrespiratory factors such as age, sex, arousal state, emotion, and attention can affect individual's sensory gating (Davenport and Vovk, 2009;Guterman et al, 1992;Hetrick et al, 1996;Kisley et al, 2001Kisley et al, , 2005Neylan et al, 1999). Among these factors, attention is of critical importance (Guterman et al, 1992;Hillyard et al, 1973;Hotting et al, 2003).…”

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confidence: 99%

Respiratory-Related-Evoked Potential Measures of Respiratory Sensory Gating in Attend and Ignore Conditions

Chan

Davenport

2009

Journal of Clinical Neurophysiology

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Respiratory sensory gating is evidenced by decreased respiratory-related-evoked potentials (RREP) amplitude of the N1 peak for the second stimulus (S2) when two occlusions are separated by a 500-millisecond interval. The RREP N1 peak amplitude ratio of the S2 and the first occlusion (S1), S2/S1, is usually <0.5. Controlled attention of respiratory loads is measured by the P300 peak of the RREP. We hypothesized that the paired occlusion elicited N1 and the P300 peak amplitudes will be modulated by controlled attention. The RREP was recorded in ignore and attend trials. The amplitudes of the RREP Nf, P1, N1, and P300 peaks for S1 and S2 and the S2/S1 ratios were measured for both trials. The S1 amplitudes of the Nf, P1, and N1 peaks were not significantly different between the attend and ignore conditions. The S2 Nf, P1, and N1 peak amplitudes were not significantly different between conditions but were all significantly less than S1. The S2/S1 ratios for Nf, P1, and N1 peaks were not significantly different between the attend and ignore conditions. The S1 RREP P300 peak amplitude in attend trials was significantly greater than in ignore trails. The attend S1 P300 amplitude was significantly greater than the attend S2 amplitude. The attend P300 S2/S1 ratio was significantly less than the ignore ratio. These results demonstrated that respiratory gating is evident in both attend and ignore conditions. The P300 peak S2/S1 ratio is consistent with controlled attention modulation of central neural gating of respiratory mechanosensation.

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Age-related change in neural processing of time-dependent stimulus features

Cited by 52 publications

References 120 publications

Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction

Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction

The relationship between preattentive sensory processing deficits and age in schizophrenia patients

Respiratory-Related-Evoked Potential Measures of Respiratory Sensory Gating in Attend and Ignore Conditions

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