Age-related Brain Metabolic Changes up to Seventh Decade in Healthy Humans

Genetic risk of dementia modifies obesity effects on white matter myelin in cognitively healthy adults

“…This pattern suggests widespread age-related white matter atrophy (ISOSF) primarily due to a loss of myelin (MPF, R1) rather than axons (ICSF, ODI) and an age-related slowing of cell metabolism (kf). Reductions in kf are consistent with findings of compromised metabolic states related to energy synthesis and oxidative stress in the aging brain (Gaignard et al, 2017;Mattson and Arumugam, 2018) and accord with a recent report of age-related changes in brain metabolites including decreases in N-acetylaspartate (NAA) concentrations (Maghsudi et al, 2019).…”

sLASER and PRESS perform similarly at revealing metabolite‐age correlations at 3 T

“…However, there is a lack of data for sLASER in the literature with which to compare. Negative metabolite‐age correlations have been reported for tNAA in the literature 24,27,57 ; however, our results indicate no significant correlation with aging for tNAA for both PRESS and sLASER, possibly due to regional differences compared with the literature. Overall, PRESS and sLASER produced very similar results in metabolite‐age concentration relationships: For most metabolites, they agreed either in observing a metabolite‐age correlation or not observing any.…”

Replicability of proton MR spectroscopic imaging findings in mild traumatic brain injury: Implications for clinical applications

“…Three-dimensional 1 H MRSI data were acquired using a validated ( Ding et al, 2015 ) and widely used ( e.g., Lecocq et al, 2015 , Sabati et al, 2015 , Ding et al, 2016 , Zhang et al, 2018 , Maghsudi et al, 2020a , Maghsudi et al, 2020b , Zhang et al, 2020 ) echo-planar spectroscopic imaging (EPSI) prototype sequence with lipid inversion nulling: TR = 1710 ms, TE = 17.6 ms, flip angle = 73°, TI = 198 ms, FOV = 280 × 280 × 135 mm 3 , matrix = 50 × 50 × 18, nominal voxel volume = 0.235 cm 3 , 16:49 min. A 280 × 280 × 100 mm 3 excitation slab covered the base of the occipital lobe through the top the brain, parallel to the AC-PC axis, as shown in Fig.…”