Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles
Jessica A. Noche,
Hamsanandini Radhakrishnan,
Margo F. Ubele
et al.
Abstract:Aging dogs serve as a valuable preclinical model for Alzheimer's disease (AD) due to their natural age-related development of beta-amyloid (Aβ) plaques, human-like metabolism, and large brains that are ideal for studying structural brain aging trajectories from serial neuroimaging. Here we examined the effects of chronic treatment with the calcineurin inhibitor (CNI) tacrolimus or the nuclear factor of activated T cells (NFAT)-inhibiting compound Q134R on age-related canine brain atrophy from a longitudinal st… Show more
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