Age-related behavioral and neurobiological changes: A review with an emphasis on memory

Kubanis, Patricia; Zornetzer, Steven F.

doi:10.1016/s0163-1047(81)91195-x

Cited by 219 publications

(57 citation statements)

References 206 publications

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“…This was shown years ago for other incidental learning (9,15). The one-trial memory task, whose persistence declines with age in rodents (8,9), is, of course, also incidental, as are all laboratory training and testing in this kind of task. 0.6 Ϯ 0.3 (6) MPH, methylphenidate.…”

Section: Discussionsupporting

confidence: 53%

“…8, 9, 23). It has been known for a long time that mnemonic and anatomical signs of decline appear in the human brain decades before senescence and progressively increase with age, starting as early as the age of 40 years or so (9,15).…”

Section: Discussionmentioning

confidence: 99%

“…Memories acquired without formal training and/or expectation of a retention test are called incidental (9,(14)(15)(16)(17). No doubt, a major part of regular declarative memories is incidental (18,19); we just learn as we live.…”

mentioning

confidence: 99%

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Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration

Izquierdo

Bevilaqua

Rossato

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Healthy human volunteers 16 -82 years of age with at least 10 years of schooling were exposed to two different memory tasks. The first task involved incidental memory. The subjects were asked, as casually as possible: ''Did you watch any movie on TV 2 days ago? And 7 days ago? If so, do you remember the title of the movie(s) and the name of the first two actors (actresses)?'' Retention scores (maximum ‫؍‬ 3: title, actor 1, and actor 2) were equally high (overall mean ‫؍‬ 2.6, n ‫؍‬ 61) in all age groups (16 -20, 21-30, 31-40, 41-60, and 61-82 years) for the day 2 scores. Scores for the movie seen 7 days before decreased significantly and progressively in the three older groups in relation to age, which indicates reduced persistence of this type of memory beginning at the age of 41-50 years and becoming more extensive over the years. The other task was a formal memory procedure. Subjects were asked to study a brief text with factual information on the 1954 World Soccer Cup for 10 min. They were then exposed to 10 questions on the text 2 days and, again, 7 days later. Retention scores declined between the two tests, but in this task, the decline of persistence occurred to a similar extent in all age groups, and thus was not dependent on age. Methylphenidate (10 mg p.o.) given 12 hours after acquisition markedly enhanced persistence of the two memory types. This suggests an involvement of dopaminergic processes in persistence in the late posttraining period.aging ͉ human aging ͉ incidental memory ͉ formal memory

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration

Izquierdo

Bevilaqua

Rossato

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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“…Furthermore, both cholinergic [32] and memory deficits [72] occur also in normal aging, although these dysfunctions differ qualitatively and quantitatively from those reported in AD. These observations, together with a wealth of data showing that anticholinergic drugs, such as scopolamine and atropine, produced learning and memory deficits [25,35,44], have led to the cholinergic hypothesis of geriatric cognitive dysfunction [10].…”

Section: Introductionmentioning

confidence: 63%

Interactions between histaminergic and cholinergic systems in learning and memory

Bacciottini

Passani

Mannaioni

et al. 2001

Behavioural Brain Research

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The aim of this review is to survey biochemical, electrophysiological and behavioral evidence of the interactions between the cholinergic and histaminergic systems and evaluate their possible involvement in cognitive processes. The cholinergic system has long been implicated in cognition, and there is a plethora of data showing that cholinergic deficits parallel cognitive impairments in animal models and those accompanying neurodegenerative diseases or normal aging in humans. Several other neurotransmitters, though, are clearly implicated in cognitive processes and interact with the cholinergic system. The neuromodulatory effect that histamine exerts on acetylcholine release is complex and multifarious. There is clear evidence indicating that histamine controls the release of central acetylcholine (ACh) locally in the cortex and amygdala, and activating cholinergic neurones in the nucleus basalis magnocellularis (NBM) and the medial septal area-diagonal band that project to the cortex and to the hippocampus, respectively. Extensive experimental evidence supports the involvement of histamine in learning and memory and the procognitive effects of H 3 receptor antagonists. However, any attempt to strictly correlate cholinergic/histaminergic interactions with behavioral outcomes without taking into account the contribution of other neurotransmitter systems is illegitimate. Our understanding of the role of histamine in learning and memory is still at its dawn, but progresses are being made to the point of suggesting potential treatment strategies that may produce beneficial effects on neurodegenerative disorders associated with impaired cholinergic function.

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“…The loss of short-term memory with aging, at one time a controversial hypothesis, has now been conclusively established, although the magnitude of the deficit is highly task-dependent (see Kubanis & Zornetzer, 1981;Meudell, 1983, for reviews). Variations of the delayed-response problem have been used in successful demonstrations of age-dependent deterioration of performance by nonhuman primates including rhesus monkeys (Bartus, Fleming & Johnson, 1978;Medin, 1969), capuchin monkeys (Bartus, Dean, & Beer, 1980), and chimpanzees (Riopelle & Rogers, 1965) .…”

mentioning

confidence: 99%

Error analysis of delayed response in aged squirrel monkeys

King

Michels

1989

Animal Learning & Behavior

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Young adult and aged squirrel monkeys were tested on variations of a two-choice, spatial delayedresponse task, Aged monkeys committed more errors than did young monkeys. However, the diminished accuracy of the aged monkeys was not attributable to a memory deficiency because the difference was independent of delay interval. Aged monkeys did not display less responsesequence variability and were no more likely to commit systematic errors than were young monkeys. When response accuracy decreased as a result of increased delay intervals, or absence of a predelay cue, both age groups increased the proportion of errors attributable to random responding; however, the proportion of errors attributable to systematic errors either decreased or remained constant.

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Age-related behavioral and neurobiological changes: A review with an emphasis on memory

Cited by 219 publications

References 206 publications

Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration

Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration

Interactions between histaminergic and cholinergic systems in learning and memory

Error analysis of delayed response in aged squirrel monkeys

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