Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan

Sawahata, Michiru; Sugiyama, Yukihiko; Nakamura, Yosikazu; Nakayama, Masayuki; Mato, Naoko; Yamasawa, Hideaki; Bando, Masashi

doi:10.1016/j.rmed.2014.12.012

Cited by 64 publications

(50 citation statements)

References 28 publications

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“…We also found, as expected, an increased risk of sarcoidosis in black women compared with white women, with very similar estimates to those previously reported (6). Sarcoidosis has often been described as a disease occurring most commonly in younger adults, although there is some recent evidence of an increasing age at diagnosis in various populations (25,26) as well as differences in age at onset by race (27). In a U.S. population, the peak in annual incidence in white women was observed at age 40 to 49 years and a decade earlier in black women (6).…”

Section: Discussionsupporting

confidence: 90%

“…A recent study in Japan found that in women, only the second peak was still observed in the last decade (25). In the current study, women were already aged 25 to 44 years at baseline, and incidence in young adulthood could not be assessed; however, our results are consistent with an increase in sarcoidosis incidence after the age of 50 years for women.…”

Section: Brief Communicationsupporting

confidence: 63%

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Epidemiology of Sarcoidosis in a Prospective Cohort Study of U.S. Women

et al. 2016

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Rationale: Sarcoidosis is a systemic granulomatous and inflammatory disorder that most often involves the lungs but also affects many other organs. Data on sarcoidosis from large epidemiological studies remain scarce.Objectives: To evaluate the baseline prevalence and 22-year incidence of sarcoidosis and their associations with demographic and geographic characteristics in a large cohort of U.S. women. Methods:The Nurses' Health Study II is a prospective cohort study of U.S. female nurses enrolled in 1989 (aged 25-44 yr, n = 116,430). Data on major illnesses were collected through biennial questionnaires . Cases were identified by the nurses' self-report of physician-diagnosed sarcoidosis. Associations of demographic and geographic characteristics with sarcoidosis were evaluated by logistic regression and Cox models. Measurements and Main Results:A total of 377 sarcoidosis cases were identified. The baseline prevalence was 100/100,000 women. The average annual incidence rate was 11/100,000 during 2,275,028 person-years of follow up. Incidence rate increased with age (P = 0.003), from 9 to 15/100,000 in women aged less than 35 to 55 or more years, respectively. Black women had a higher prevalence (odds ratio, 5.24; 95% confidence interval, 2.87-9.55) and incidence (hazard ratio, 3.80; 95% confidence interval, 2.31-6.24) than white women. Across U.S. regions, more than twofold differences were observed in sarcoidosis prevalence and incidence, with consistently higher rates in the Northeast. Conclusions:We provide recent national data on the epidemiology of sarcoidosis among U.S. women. Important differences in prevalence and incidence were observed across U.S. regions. Large epidemiological studies are needed to better understand the causes of the observed demographic and geographic differences in sarcoidosis.

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Section: Discussionsupporting

confidence: 90%

Section: Brief Communicationsupporting

confidence: 63%

Epidemiology of Sarcoidosis in a Prospective Cohort Study of U.S. Women

et al. 2016

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“…Even though it was previously reported that the presence of hypercalcemia increases after 45 years of age [19], another study did not find differences in calcium values among elderly patients (≥65 years) [5]. We did not find a significant difference in serum calcium levels between groups.…”

Section: Discussioncontrasting

confidence: 92%

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2017

Eurasian J Med

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Objective: While the incidence of sarcoidosis peaks between 20 and 39 years, it is comparatively low in elderly subjects. We sought to determine whether there are age-dependent differences in the demographic and laboratory characteristics of patients with sarcoidosis. Materials and Methods: We retrospectively collected information from our database using the International Classification of Disease (ICD) diagnostic code D86 between 2008 and 2014. Patients were divided into three groups: 20-39 years old (Group 1), 40-59 years old (Group 2), and 60-80 years old (Group 3). Results: A total of 3988 patients with code of D86 were included in the study. After the exclusion of noneligible patients, the number of cases in Groups 1, 2, and 3 were 276, 641, and 352, respectively. The groups were compared according to demographic characteristics, ICD diagnostic codes, and laboratory parameters. The ratio of female patients was significantly higher in Group 3 than in Groups 1 and 2 (p=0.000). There was no difference in diagnostic codes of the ICD subgroups between groups (p=0.19). While the level of bloodurea nitrogen was significantly higher in Group 3 patients than in other groups (p=0.000), serum angiotensinconverting enzyme (ACE) values were found to be significantly low in Group 3 (p=0.010). The mean ACE values did not differ between females and males (50.8±39.3 and 59.1±45.5 mg/dL, respectively) (p=0.18). Conclusion:The majority of patients with sarcoidosis were female in all age groups and pulmonary sarcoidosis was the most common presentation of the disease. Elderly patients (≥60 years) with sarcoidosis had lower serum ACE levels than younger patients.

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“…[123] It typically affects women in the age group from 20 to 60 years. It is diagnosed pathologically by the presence of noncaseating granulomas on biopsy of the lesion and presents in one or more of the following ways – pulmonary involvement in the form of hilar adenopathy or reticular shadows or extrapulmonary involvement in the form of eye/joint/skin/cardiac/central nervous system lesions.…”

Section: Discussionmentioning

confidence: 99%

Dry cough in a middle-aged man

Singh

Singh²,

Jindal

2016

Lung India

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Cough is often a distressing feature and may be caused due to varied reasons. A 39-year-old man presented with complaints of cough and had significant pigeon exposure. His chest X-ray revealed mediastinal enlargement and computed tomography chest revealed air trapping and mediastinal lymphadenopathy. Both endobronchial and transbronchial biopsies revealed granulomas. Thus, the patient was diagnosed as a case of sarcoidosis and started on steroids. Hypersensitivity pneumonitis may often mimic sarcoidosis; however, the presence of endobronchial granulomas will diagnose the latter condition.

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Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan

Abstract: Elderly patients at diagnosis had various extrathoracic involvement including eye, skin, and cardiac lesions. Moreover, the age at diagnosis of sarcoidosis has continued to increase in both sexes, influencing the recent trends in clinical characteristics.

Cited by 64 publications

References 28 publications

Epidemiology of Sarcoidosis in a Prospective Cohort Study of U.S. Women

Epidemiology of Sarcoidosis in a Prospective Cohort Study of U.S. Women

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Dry cough in a middle-aged man

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