Age-related alterations in emotional behaviors and amygdalar corticotropin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats

Pisarska, Marta M.; Mulchahey, J.J.; Welge, Jeffrey A.; Geracioti, Thomas D.; Kasckow, John

doi:10.1016/s0006-8993(00)02606-8

Cited by 35 publications

(19 citation statements)

References 26 publications

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“…In the plus-maze, our data suggest a decrease in anxiety-related behavior over aging, in agreement with previous studies (Pisarska et al 2000;Torras-Garcia et al 2005, but Boguszewski andZagrodzka 2002;Bessa et al 2005). As this decrease was not observed in middle-aged rats, it is probably not a phenomenon protracting over lifespan.…”

Section: Emotional Behaviorssupporting

confidence: 93%

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Harati

Barbelivien

Herbeaux

et al. 2012

AGE

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We assessed lifelong environmental enrichment effects on possible age-related modifications in emotional behaviors, spatial memory acquisition, retrieval of recent and remote spatial memory, and cholinergic forebrain systems. At the age of 1 month, Long-Evans female rats were placed in standard or enriched rearing conditions and tested after 3 (young), 12 (middle-aged), or 24 (aged)months. Environmental enrichment decreased the reactivity to stressful situations regardless of age. In the water maze test, it delayed the onset of learning deficits and prevented age-dependent spatial learning and recent memory retrieval alterations. Remote memory retrieval, which was altered independently of age under standard rearing conditions, was rescued by enrichment in young and middle-aged, but unfortunately not aged rats. A protected basal forebrain cholinergic system, which could well be one out of several neuronal manifestations of lifelong environmental enrichment, might have contributed to the behavioral benefits of this enrichment.

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Section: Emotional Behaviorssupporting

confidence: 93%

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Harati

Barbelivien

Herbeaux

et al. 2012

AGE

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“…These data suggest that, normally, activation of the 5-HT-3A receptor inhibits expression of CRH in the central nucleus of the amygdala. Elevated levels of CRH mRNA in the central nucleus of the amygdala tend to be correlated or associated with increased anxiety in the elevated plus maze [49,50]. However, the increased CRH mRNA we observed in the central amygdala of KO mice was not associated with increased measures of anxiety in the plus maze, open field, or light -dark tests.…”

Section: Discussioncontrasting

confidence: 51%

Changes in anxiety-related behaviors and hypothalamic–pituitary–adrenal activity in mice lacking the 5-HT-3A receptor

Bhatnagar

Sun

Raber

et al. 2004

Physiology & Behavior

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The serotonin-3 (5-HT-3A) receptor has been localized in limbic and brainstem structures that regulate anxiety-related behavior and hypothalamic -pituitary -adrenal (HPA) activity, but its role in regulating anxiety-related behaviors is equivocal, and evidence for its role in regulating HPA activity is limited. Therefore, we used 5-HT-3A receptor knockout (KO) mice to further study these issues. Behavior in the elevated plus maze, open field, light -dark box and after Pavlovian fear conditioning was examined in addition to HPA activity under basal and acute stress conditions. Compared to age-matched adult male wild-type (WT) controls, adult male KO mice exhibited increased distance traveled in the open arms of the elevated plus maze, consistent with decreased measures of anxiety. There were no differences between the two genotypes in exploratory behavior in the open field or light -dark test. KO mice displayed enhanced fear conditioning indexed by fearinduced freezing behavior. KO mice displayed lower adrenocorticotropin (ACTH) responses to restraint or lipopolysaccharide (LPS). In addition, lower vasopressin mRNA in the paraventricular nucleus of the hypothalamus (PVN) and higher corticotropin-releasing hormone (CRH) mRNA in the central amygdala were observed in KO compared to WT mice. Therefore, deletion of the 5-HT-3A receptor revealed an important role for this receptor in regulating HPA responses to acute stress and a potential interaction between the 5-HT-3A receptor and CRH in the amygdala. Together, these data suggest that the 5-HT-3A receptor does not have a unitary role in the regulation of anxiety-and fear-related behaviors but has a potentially substantial role in the regulation of HPA activity. D 2004 Elsevier Inc. All rights reserved.

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“…However, previous studies showed middle-aged related differences in plasmatic CORT or corticotropin-releasing factor responses to different types of stress when compared to young animals (Nolan et al, 1991;Pisarska et al, 2000). Reports of increased CORT levels for 3 days post-stress exist (Gaillet et al, 1991;Ottenweller et al, 1994), however, in most cases, the plasmatic CORT response corresponds to a transitory peak occurring within the first 30 min post (stress) stimulus (Xu et al, 1997).…”

Section: Gsm Exposure Stress and Emotional Memorymentioning

confidence: 94%

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Bouji¹,

Lecomte²,

Hode³

et al. 2012

Experimental Gerontology

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. Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats. Experimental Gerontology, Elsevier, 2012, 47 (6) ABSTRACTThe widespread use of mobile phones raises the question of the effects of electromagnetic fields (EMF, 900 MHz) on the brain. Previous studies reported increased levels of the glial fibrillary acidic protein (GFAP) in the rat's brain after a single exposure to 900 MHz global system for mobile (GSM) signal, suggesting a potential inflammatory process. While this result was obtained in adult rats, no data is currently available in older animals. Since the transition from middle-age to senescence is highly dependent on environment and lifestyle, we studied the reactivity of middle-aged brains to EMF exposure. We assessed the effects of a single 15 min GSM exposure (900MHz; specific absorption rate (SAR) = 6 W/kg) on GFAP expression in young adults (6 week-old) and middle-aged rats (12 month-old). Brain interleukin (IL)-1β and IL-6, plasmatic levels of corticosterone (CORT), and emotional memory were also assessed.Our data indicated that, in contrast to previously published work, acute GSM exposure did not induce astrocytes activation. Our results showed an IL-1β increase in the olfactory bulb and enhanced contextual emotional memory in GSM-exposed middle-aged rats, and increased plasmatic levels of CORT in GSM-exposed young adults. Altogether, our data showed an age dependency of reactivity to GSM exposure in neuroimmunity, stress and behavioral parameters. Reproducing these effects and studying their mechanisms may allow a better understanding of mobile phone EMF effects on neurobiological parameters.

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Age-related alterations in emotional behaviors and amygdalar corticotropin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats

Cited by 35 publications

References 26 publications

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Changes in anxiety-related behaviors and hypothalamic–pituitary–adrenal activity in mice lacking the 5-HT-3A receptor

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

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