Age of Initiation, Smoking Patterns, and Risk in a Population of Working Adults

Lando, Harry A.; Thai, Dzung; Murray, David M.; Robinson, Leslie A.; Jeffery, Robert W.; Sherwood, Nancy E.; Hennrikus, Deborah J.

doi:10.1006/pmed.1999.0590

Cited by 107 publications

(72 citation statements)

References 21 publications

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“…Although it was known that there is a high prevalence of multiple product use and an early age of tobacco use initiation among AN people ), a significant portion of participants tried using tobacco at a very young age (11 years and younger). Early age of onset of smoking has been associated with heavy smoking, higher nicotine dependence, less interest in quitting, and greater risk of disease as an adult (Lando et al, 1999). However, in this study population, the amount of tobacco consumed per day and dependence scores were relatively low.…”

Section: Discussioncontrasting

confidence: 57%

Tobacco Use Among Southwestern Alaska Native People

Renner

Lanier

Lindgren

et al. 2012

Nicotine & Tobacco Research

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Section: Discussioncontrasting

confidence: 57%

Tobacco Use Among Southwestern Alaska Native People

Renner

Lanier

Lindgren

et al. 2012

Nicotine & Tobacco Research

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“…In accordance with the observation that onset of smoking during adolescence is associated with more severe ND in adult smokers, 82,92,93 Weiss et al 82 studied a sample of 2827 long-term smokers, using a dichotomized definition of ND severity based on FTND scores: low (FTND = 0-4) and high (FTND 6-10). Six SNPs were significantly associated with ND with P-values ranging from 0.0032-0.0005 (including rs1699968, rs1051730 and rs578776) only in the early onset of smoking group (age 16 years or younger), but not in the late onset group (age 17 years or older).…”

mentioning

confidence: 89%

Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions

Greenbaum¹,

Lerer²

2009

Mol Psychiatry

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Nicotine dependence (ND), a major public health challenge, is a complex, multifactorial behavior, in which both genetic and environmental factors have a role. Brain nicotinic acetylcholine receptor (nAChR)-encoding genes are among the most prominent candidate genes studied in the context of ND, because of their biological relevance as binding sites for nicotine. Until recently, most research on the role of nAChRs in ND has focused on two of these genes (encoding the a4-and b2-subunits) and not much attention has been paid to the possible contribution of the other nine brain nAChR subunit genes (a2-a3, a5-a7, a9-a10, b3-b4) to the pathophysiology and genetics of ND. This situation has changed dramatically in the last 2 years during which intensive research had addressed the issue, mainly from the genetics perspective, and has shown the importance of the CHRNA5-CHRNA3-CHRNB4 and CHRNA6-CHRNB3 loci in ND-related phenotypes. In this review, we highlight recent findings regarding the contribution of non-a4/b2-subunit containing nAChRs to ND, based on several lines of evidence: (1) human genetics studies (including linkage analysis, candidate-gene association studies and whole-genome association studies) of several ND-related phenotypes; (2) differential pharmacological and biochemical properties of receptors containing these subunits; (3) evidence from genetically manipulated mice; and (4) the contribution of nAChR genes to ND-related personality traits and neurocognitive profiles. Combining neurobiological genetic and behavioral perspectives, we suggest that genetic susceptibility to ND is not linked to one or two specific nAChR subtype genes but to several. In particular, the a3, a5-6 and b3-4 nAChR subunit-encoding genes may play a much more pivotal role in the neurobiology and genetics of ND than was appreciated earlier. At the functional level, variants in these subunit genes (most likely regulatory) may have independent as well as interactive contributions to the ND phenotype spectrum. We address methodological challenges in the field, highlight open questions and suggest possible pathways for future research.

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“…Similarly, early smoking onset is associated with daily smoking, daily quantity of cigarettes and long smoking careers (Grant 1998;Lando et al 1999), as well as excessive alcohol consumption and alcohol use disorders (Grant 1998). As alcohol and tobacco are generally the first drugs with which adolescents experiment (Shiffman & Balabanis 1995), it is likely that initiation of drinking among non-drinkers will be highly associated with prior smoking (and initiation of smoking among non-smokers will be highly associated with prior drinking).…”

Section: Introductionmentioning

confidence: 99%

Adolescent alcohol and tobacco use: onset, persistence and trajectories of use across two samples

et al. 2002

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Aims-We examined the alcohol-tobacco relationship using two prospective, ethnically diverse samples. Trajectories of alcohol and tobacco use are portrayed overall and by sex and ethnicity. Using prospective analyses, we examine directional influences between alcohol and tobacco use, and we characterize initiation versus persistence of drinking and smoking as a function of use of the other substance.Design, setting-Data were from the National Longitudinal Study of Adolescent Health (AddHealth) and the Adolescent Health Risk Study (AHRS). Follow-up intervals for AddHealth and AHRS were 1 and 5 years, respectively.Participants-AddHealth respondents (n = 4831) were on average 14.8 years old (48% male, 23% black, 61% white) and AHRS respondents (n = 1814) were on average 16.7 years old (47% male, 44% black, 49% white).Measurements-Two alcohol consumption variables and two smoking variables were used: drinking frequency and heavy drinking frequency, and regular (current) smoking and daily number of cigarettes.Findings-Alcohol and tobacco use exhibited monotonic increases over adolescence and young adulthood. Men and white respondents reported more use than women and black respondents. Alcohol and tobacco were moderately associated at both times. Analyses revealed that prior alcohol use predicted tobacco use more strongly than the converse. Initiation of smoking was a function of prior drinking; to a lesser extent, initiation of drinking was a function of prior smoking. Persistence of smoking was a function of prior drinking and persistence of drinking was a function of prior smoking.Conclusions-Provisional support exists for the claim that alcohol use predicts tobacco use more strongly than the converse. For both drinking and smoking, onset and persistence are predicted by prior use of the other substance, and these associations were robust across sex and ethnicity.

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Age of Initiation, Smoking Patterns, and Risk in a Population of Working Adults

Cited by 107 publications

References 21 publications

Tobacco Use Among Southwestern Alaska Native People

Tobacco Use Among Southwestern Alaska Native People

Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions

Adolescent alcohol and tobacco use: onset, persistence and trajectories of use across two samples

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