Age Modulates the Association of Caffeine Intake With Cognition and With Gray Matter in Elderly Diabetics

West, Rebecca; Ravona‐Springer, Ramit; Livny, Abigail; Heymann, Anthony; Shahar, Danit R.; LeRoith, Derek; Preiss, Rachel; Zukran, Ruth; Silverman, Jeremy M.; Schnaider‐Beeri, Michal

doi:10.1093/gerona/gly090

Cited by 17 publications

(33 citation statements)

References 41 publications

(59 reference statements)

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“…Kimura et al discovered that L-theanine plays a positive role in anti-stress by reducing stress-induced heart rate and salivary immunoglobulin A (s-lgA) during a stressed mental arithmetic task [3]. The beneficial effect of caffeine on cognitive functioning was reported at least two decades ago [17] and replicated by recent studies [18, 19]. Although individual constituents of tea have been related to the roles of maintaining cognitive abilities and preventing cognitive decline, a study with behavioural and neurophysiological measures showed that there was a degraded effect or no effect when a constituent was administered alone and a significant effect was observed only when constituents were combined [20].…”

Section: Introductionmentioning

confidence: 99%

Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation

Romero-García

Suckling

et al. 2019

Aging

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The majority of tea studies have relied on neuropsychological measures, and much fewer on neuroimaging measures, especially for interregional connections. To date, there has been no exploration of the effect of tea on system-level brain networks. We recruited healthy older participants to two groups according to their history of tea drinking frequency and investigated both functional and structural networks to reveal the role of tea drinking on brain organization. The results showed that tea drinking gave rise to the more efficient structural organization, but had no significant beneficial effect on the global functional organization. The suppression of hemispheric asymmetry in the structural connectivity network was observed as a result of tea drinking. We did not observe any significant effects of tea drinking on the hemispheric asymmetry of the functional connectivity network. In addition, functional connectivity strength within the default mode network (DMN) was greater for the tea-drinking group, and coexistence of increasing and decreasing connective strengths was observed in the structural connectivity of the DMN. Our study offers the first evidence of the positive contribution of tea drinking to brain structure and suggests a protective effect on age-related decline in brain organisation.

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Section: Introductionmentioning

confidence: 99%

Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation

Romero-García

Suckling

et al. 2019

Aging

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“…Penelitian yang dilakukan oleh West et al (2019) pada sampel individu lansia dengan diabetes melitus tipe 2 (DM tipe 2), didapatkan bahwa tingkat asupan kafein yang lebih tinggi secara signifikan berkaitan dengan kinerja kognitif yang lebih baik dan volume gray matter yang lebih besar. Asupan kafein memiliki hubungan yang kecil akan tetapi signifikan dengan kognisi keseluruhan (p = 0,018), memori kerja / perhatian (p = 0,002), kategorisasi semantik (p = 0,026), dan fungsi eksekutif (p =.…”

Section: Hasil Dan Pembahasanunclassified

“…Asupan kafein memiliki hubungan yang kecil akan tetapi signifikan dengan kognisi keseluruhan (p = 0,018), memori kerja / perhatian (p = 0,002), kategorisasi semantik (p = 0,026), dan fungsi eksekutif (p =. 047) (West et al, 2019). Hal ini juga sejalan dengan penelitian oleh eskelinen et al (2010), bahwa konsumsi kopi sebanyak 3-5 cangkir per hari memiliki 65-70% penurunan risiko demensia dan 62-64% penurunan risiko penyakit alzheimer dibandingkan dengan konsumsi kopi yang lebih sedikit (p≤ 0,05) (Eskelinen & Kivipelto, 2010).…”

Section: Hasil Dan Pembahasanunclassified

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Konsumsi Kopi untuk Mencegah Penyakit Alzheimer

Husodo

2020

jiskh

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Abstract. Coffee is one of the most consumed beverages in the world and most adults drink coffee every day. Coffee contains hundreds of bioactive compounds, including caffeine, chlorogenic acid, polyphenols, and small amounts of minerals and vitamins, which are known to have positive effects on brain health. Alzheimer's disease is a degenerative disease of the brain and the most common cause of dementia characterized by decreased memory, language, problem solving and other cognitive skills that affect a person's ability to perform daily activities. The purpose of this literature study is to determine the benefits of coffee consumption in preventing Alzheimer's disease. Method. This research is a literature study and library sources used involving 15 libraries from 1 national journal and 14 international journals. Result. Several studies have shown the preventive effects of coffee on Alzheimer's disease and cognitive decline through various mechanisms such as a role in lowering plasma Aβ levels, as well as an antioxidant that can reduce inflammation and protect against dementia. Conclusion. Coffee can have a protective effect on Alzheimer's disease and is safe to consume if it does not exceed the recommended dosage. Abstract. Kopi adalah salah satu minuman yang paling banyak dikonsumsi di dunia dan sebagian besar or ang dewasa minum kopi setiap hari. Kopi mengandung ratusan senyawa bioaktif, termasuk kafein, asam klorogenat, polifenol, dan sejumlah kecil mineral dan vitamin yang di antaranya diketahui memiliki efek positif bagi kesehatan otak. Penyakit Alzheimer adalah penyakit degeneratif pada otak dan penyebab paling umum dari demensia yang ditandai dengan penurunan daya ingat, bahasa, pemecahan masalah, dan keterampilan kognitif lain yang memengaruhi kemampuan seseorang untuk melakukan aktivitas sehari-hari. Tujuan dari studi literatur ini adalah untuk mengetahui manfaat konsumsi kopi untuk mencegah penyakit Alzheimer. Metode. Penelitian ini merupakan studi literatur dan sumber pustaka yang digunakan melibatkan 15 pustaka yang berasal dari 1 jurnal nasional dan 14 jurnal internasional. Hasil. Beberapa studi menunjukkan efek pencegahan dari kopi pada penyakit Alzheimer dan penurunan kognitif melalui berbagai mekanisme misalnya berperan dalam penurunan kadar Aβ plasma,serta sebagai antioksidan yang dapat mengurangi peradangan dan melindungi dari demensia. Kesimpulan. Kopi dapat memberikan efek protektif pada penyakit alzheimer serta aman dikonsumsi apabila tidak melebihi dosis yang dianjurkan

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“…They are ubiquitous in human biological fluids [12][13][14], serum/plasma, particularly, cannot be excluded, previous research has reported that trace amounts of CA and/or its several metabolites were detected in serum from normal adults, even in human subjects who had abstained from methylxanthines for 1 week [15][16][17]. Recently, studies have shown that CA is also associated with cognitive function and white matter lesions in the elderly [18][19][20][21][22]. It was reported that serum levels of CA and its metabolites were significantly decreased in patients with early PD [19,23].…”

Section: Introductionmentioning

confidence: 99%

Detection of caffeine and its main metabolites for early diagnosis of Parkinson's disease using micellar electrokinetic capillary chromatography

et al. 2020

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Caffeine (CA) is a common xanthine alkaloid found in tea leaves, coffee beans, and other natural plants, and is the most widely used psychotropic substance in the world. Accumulating evidence suggests that low plasma levels of CA and its metabolites may serve as reliable diagnostic markers for early Parkinson's disease (PD) patients. In this study, we demonstrated a new MEKC method for determining CA and its three main downstream metabolites, paraxanthine (PX), theobromine (TB), and theophylline (TP), in human plasma. Plasma samples were collected, and analyzed using MEKC, after SPE. The running buffer was composed of 35 mM phosphate, pH of 10.5, and 25 mM SDS. The separation voltage was 15 kV and the detection wavelength was at 210 nm. Under the optimum conditions, four distinct analytes were completely separated and detected in less than 12 min. Method limits of detection were as low as 7.5 ng/mL for CA, 5.0 ng/mL for TB, and 4.0 ng/mL for both PX and TP. The recoveries were between 88.0% and 105.9%. This method was successfully applied to 27 human plasma samples. The results indicate that the plasma concentrations of the four analytes are significantly lower in patients with early PD than in control subjects (p < 0.05). The area under curve was improved to 0.839 when CA and its three main metabolites were included, suggesting that MEKC testing of CA, TP, TB, and PX may serve as a potential method for early diagnosis of PD.

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Age Modulates the Association of Caffeine Intake With Cognition and With Gray Matter in Elderly Diabetics

Abstract: Caffeine intake may have a beneficial role in cognitive functioning of elderly adults with T2D, which may be moderated by age. Greater GM volume may be a mechanism underlying the association of higher caffeine intake with better cognitive function.

Cited by 17 publications

References 41 publications

Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation

Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation

Konsumsi Kopi untuk Mencegah Penyakit Alzheimer

Detection of caffeine and its main metabolites for early diagnosis of Parkinson's disease using micellar electrokinetic capillary chromatography

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