Age Matching Improves Graft Survival After Living Donor Kidney Transplantation

Lee, S.H.; Oh, Chang‐Keun; Shin, Gyu‐Tae; Kim, H.; Kim, S.J.

doi:10.1016/j.transproceed.2013.10.049

Cited by 11 publications

(6 citation statements)

References 18 publications

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“…Using data from 1269 patients, 44 of whom had a donor older than 55, Waiser et al (2000) found that kidneys from donors >55 increased the risk of graft failure in young recipients (<55) almost two-fold but had no significant effect in older recipients (>55). In their univariate analysis of 201 live donor kidney transplantation recipients, Lee et al (2014) found that the 10-year graft survival of recipients with donors >10 years younger than the recipients was reduced in comparison to those instances in which the ages of recipient and donor were matched (i.e. <10 years of difference between the recipient and their donor).…”

Section: Resultsmentioning

confidence: 99%

“…An exception to this pattern is the augmented risk of graft failure in transplants from pediatric donors that the studies by Baldwin et al (2013) and Laging et al (2012) found in lung and kidney transplantation data, respectively. Apart from these results, some studies in kidney transplantation have reported a relatively positive effect in patient or graft survival outcomes derived from age matching between donors and recipient (Chavalitdhamrong et al, 2008; Waiser et al, 2000; Lee et al, 2014). However, the number of recipients receiving grafts from old donors in these studies was not high enough to provide solid evidence of this.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of donor age on organ transplants: A review and implications for aging research

Dayoub

Cortese

Anžič

et al. 2018

Experimental Gerontology

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Despite the considerable amount of data available on the effect of donor age upon the outcomes of organ transplantation, these still represent an underutilized resource in aging research. In this review, we have compiled relevant studies that analyze the effect of donor age in graft and patient survival following liver, kidney, pancreas, heart, lung and cornea transplantation, with the aim of deriving insights into possible differential aging rates between the different organs. Overall, older donor age is associated with worse outcomes for all the organs studied. Nonetheless, the donor age from which the negative effects upon graft or patient survival starts to be significant varies between organs. In kidney transplantation, this age is within the third decade of life while the data for heart transplantation suggest a significant effect starting from donors over age 40. This threshold was less defined in liver transplantation where it ranges between 30 and 50 years. The results for the pancreas are also suggestive of a detrimental effect starting at a donor age of around 40, although these are mainly derived from simultaneous pancreas-kidney transplantation data. In lung transplantation, a clear effect was only seen for donors over 65, with negative effects of donor age upon transplantation outcomes likely beginning after age 50. Corneal transplants appear to be less affected by donor age as the majority of studies were unable to find any effect of donor age during the first few years posttransplantation. Overall, patterns of the effect of donor age in patient and graft survival were observed for several organ types and placed in the context of knowledge on aging.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effects of donor age on organ transplants: A review and implications for aging research

Dayoub

Cortese

Anžič

et al. 2018

Experimental Gerontology

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“…The gap between the shorter lifespan of older recipients after and the longer graft survival of younger grafts might result in higher DWGF risk. Lee et al suggested that it is better to reduce the age difference between recipients and donors for good graft survival as well as reducing the risk of DWGF [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Death with graft function after kidney transplantation: a single-center experience

Kim

Lee

et al. 2017

Clin Exp Nephrol

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BackgroundDeath with graft function (DWGF) is an important cause of long-term loss of grafts and patients. In this study, we investigated clinical characteristics and causes of DWGF in kidney transplant recipients.MethodsWe recruited kidney allograft recipients who underwent surgery during 1973–2016 at Seoul National University Hospital in Korea (n = 2137). We divided recipients into four groups: alive with graft function (AWGF), alive with graft loss (AWGL), DWGF, and death with graft loss (DWGL).ResultsAmong 455 recipients with graft loss, 88 (19.3%) lost graft function due to death. DWGF was responsible for 38.6% of a total of 228 deaths. Recipients with DWGF were older, more often diabetic, and experienced delayed graft function more often compared to patients with AWGF, AWGL, and DWGL. Additionally, they had fewer episodes of acute rejection than AWGF and AWGL patients. The majority of DWGF developed because of infection (40.9%), malignancy (28.4%), and cardiovascular disease (11.4%). Infection-related mortality was highest within the first year after transplantation. Death due to malignancy was lowest within the first year, but increased thereafter.ConclusionsIn our center, DWGF was a significant cause of graft loss. Infection and malignancy were the leading causes of DWGF during the overall post-transplantation period. Therefore, close monitoring for infection and malignancy should be instituted to lessen the burden of graft loss.

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“…Different opinion from other studies in adult KT have reported a relatively potential positive effect in patient or graft survival outcomes derived from age matching between donors and recipient [27] [28] [29] [30].…”

Section: Discussionmentioning

confidence: 92%

CD62L Percentage in Peripheral T Cells of Kidney Transplant Recipients Children

Rashad¹,

Fadel²,

Salah³

et al. 2021

OJNeph

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Backgrounds: Recent advances in post Kidney Transplantation (KT) care, have led to a dramatic improvement in short-term outcomes in order to achieve transplantation tolerance; including the ideal tool for clinical monitoring & new therapeutic line. This study was undertaken to analyze the CD62L in Kidney Transplant Recipients (KTRs) and to investigate its efficacy as a marker of good graft survival. Methods: Fifty pediatric KTRs and 12 healthy controls were included in the study, the frequency of T cell activation markers; CD62L was measured with flow cytometry after renal transplantation. Clinical, laboratory, immunosuppressive therapy data and graft function of transplant recipients were collected and correlated with their CD62L peripheral blood percentage. Results: The circulating CD62L% was significantly more in transplant recipients than controls (44.74% ± 17.45% vs. 33.36% ± 11.54%, p = 0.02). CD 62L% was more frequent in recipients of living related donors (p = 0.05), positively correlated with donor age (p = 0.04, r = −0.29*) and CD 4% (p = 0.000, r = 0.615). CD26L% did not show significant association with acute rejection or chronic rejection (p = 0.432, p = 0.91 respectively) or with graft function (serum creatinine or eGFR, p = 0.086, p = 0.988 respectively) or immunosuppressive medications. Conclusion: Peripheral CD62L% is increased after KT than healthy controls, however, it cannot reflect either clinical (serum creatinine and eGFR) or pathological renal graft injury. CD62L surface marker needs more analysis for its potential diagnostic and therapeutic implications as a Treg cell activation marker.

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Age Matching Improves Graft Survival After Living Donor Kidney Transplantation

Cited by 11 publications

References 18 publications

The effects of donor age on organ transplants: A review and implications for aging research

The effects of donor age on organ transplants: A review and implications for aging research

Death with graft function after kidney transplantation: a single-center experience

CD62L Percentage in Peripheral T Cells of Kidney Transplant Recipients Children

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