Age is not a risk factor in survival of severely ill patients with co-morbidities in a medical intensive care unit

Kır, Seher; Bahçeci, Buğra Kaan; AYRANCI, Eyüp; Balkoca, Murat; Çolak, Özkul Yılmaz; Ayrancı, Esma; Dilek, Melda

doi:10.1007/s11845-020-02298-0

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…Despite the prognostic role of age among hospitalized elderly patients [23] and the associated risk of treatment restriction in older adults [37] , this study showed that chronologic age is not a predictor of mortality and should not lead to treatment restriction. This finding is supported by other studies [7,45,46] as frailty, comorbidity and severity of illness are more important than age per se [47] . Also, gender was not found to be a predictor of mortality, supporting other findings of another prospective cohort study including hospitalized older adults [23,46] .…”

Section: Discussionsupporting

confidence: 83%

“…This finding is supported by other studies [7,45,46] as frailty, comorbidity and severity of illness are more important than age per se [47] . Also, gender was not found to be a predictor of mortality, supporting other findings of another prospective cohort study including hospitalized older adults [23,46] . There were overlapping causes of admission at HDUs; this study demonstrated that ARI and sepsis are the 2 most common principal causes of admission among critically ill older adults, following previous reports [48,49] .…”

Section: Discussionsupporting

confidence: 83%

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Predictors of in-hospital mortality in critically ill Geriatric patients

2021

IJOAR

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Objective: To determine the predictors of in-hospital mortality in critically ill older patients. Participants and Methods: A prospective cohort study including 305 critically ill older adults (age ≥60 years) who were admitted to High Dependency Units (HDUs) in a tertiary care university hospital from March 22, 2019 to January 4, 2020. Demographic, clinical and laboratory data of participants were collected thought a review of medical records and clinical observation at HDUs till either death or discharge alive. Statistical analysis included univariate analysis of selected potential predictors such as various comorbidities, C- reactive protein / Albumin ratio (CAR), Neutrophil-lymphocyte ratio (NLR), Red cell distribution width (RDW), Po2/Fio2 ratio (PFR), Simplified acute physiology score II (SAPS II), Charlson comorbidity index (CCI) and multidrug-resistant Gram-negative bacterial (MDR-GNB) infection to ascertain their association with mortality, followed by multivariable logistic regression to derive the final prediction model. The discriminative ability of the model was evaluated by using the receiver operating characteristic (ROC) curve. RESULTS: Overall mortality was 53.1%. Multivariate regression analysis revealed independent predictors of mortality including dementia in clinical history with an odds ratio (OR) of 4.86 (95% CI: 1.28-18.34), total protein with an OR of .53 (95% CI: .30-.95) and the use of mechanical ventilation (MV) and/or intravenous cardiovascular support with an OR of 148.34 (95% CI: 34.28-641.77), formulating a novel prognostic model with an area under the ROC curve of .93 (95% CI: .89-.96, P.000). CONCLUSION: History of dementia, total protein and the use of MV and/or intravenous cardiovascular support are predictors of mortality in critically ill geriatric patients. It provides a novel prognostic model which needs validation in other multicenter prospective studies.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

Predictors of in-hospital mortality in critically ill Geriatric patients

2021

IJOAR

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“…In addition, recent studies also demonstrated age to be independently associated with increased mortality in patients with ARDS [ 22 , 23 ], and older patients had higher mortality rate than younger patients [ 9 , 24 , 25 ]. However, Kır et al reported no significant differences in mortality between older patients and younger patients [ 26 ]. In our study, 58.4% of the patients aged no less than 65 years.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding patients with ARDS, older patients have been reported with more co-morbidities and higher disease severity [ 3 , 9 , 12 , [24] , [25] , [26] ]. Although these results may contribute to higher rates of mortality of older patients, the results of published studies were controversial.…”

Section: Discussionmentioning

confidence: 99%