Age is not a contraindication to pancreaticoduodenectomy

Hodul, Pam; Tansey, Joseph; Golts, Eugene; Oh, Daniel D.; Pickleman, Jack; Aranha, Gerard V.

doi:10.1016/s0016-5085(00)81967-8

Cited by 44 publications

(59 citation statements)

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“…A total of 21 studies were identified (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). A total of 6,933 PDs were collected, and of these, 1,931 PDs (27.9%) were performed in elderly patients.…”

Section: Systematic Reviewmentioning

confidence: 99%

Age does not affect complications and overall survival rate after pancreaticoduodenectomy: Single-center experience and systematic review of literature

Miyazaki

Kobayashi

Amikura

et al. 2016

BST

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Section: Systematic Reviewmentioning

confidence: 99%

Age does not affect complications and overall survival rate after pancreaticoduodenectomy: Single-center experience and systematic review of literature

Miyazaki

Kobayashi

Amikura

et al. 2016

BST

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“…Although the elderly population has a higher prevalence of comorbidities, American Society of Anesthisiologists (ASA) scores and co-morbidities were evenly distributed between the two age groups [36,39,40,42,43]. Furthermore, patients with ASA grade IV were either excluded from pancreatic resection or were in the minority [24, 32-34, 38, 39].…”

Section: Pancreatic Resection For Pancreatic and Ampullary Cancermentioning

confidence: 99%

Should We Deny Surgery for Malignant Hepato‐Pancreatico‐Biliary Tumors to Elderly Patients?

Petrowsky

Clavien

2005

World j. surg.

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Abstract. Malignant hepato-pancreatico-biliary (HPB) tumors have their highest incidence within the sixth to eighth decades of life. The aging of the world population has resulted in a dramatic increase in the number of elderly patients considered for resection of malignant HPB tumors. Because elderly patients are more likely to have more co-morbidities, cognitive impairment, and decreased life expectancy, the benefit and appropriateness of these procedures must be scrutinized for geriatric patients. Therefore, many surgeons have compared the perioperative and long-term outcome of hepatic and pancreatic resections for elderly and younger patients. In most series the elderly population was defined by an age of 70 years or older. The results demonstrate that hepatic resection for hepatocellular carcinoma and colorectal liver metastases can be safely performed in well-selected elderly patients with long-term outcome comparable to younger patients. Similar findings are also reported for pancreatic resection in elderly patients with either ampullary or pancreatic cancer. Although the survival benefit of pancreatico-duodenectomy is limited in all age groups, the absence of competitive therapy justifies this procedure as the sole curative option in younger as well as older patients. Data on resection of gallbladder cancer and hilar bile duct cancer in the elderly are sparse, but there is evidence from large series on resection of these types of tumors that advanced age per se is not a risk factor for reduced outcome. Therefore, surgical options should not be denied to elderly patients with a malignant HPB tumor, and the evaluation should include surgeons expert in HPB surgery.

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“…Similar results have been reported by others. Hodul et al [6] studied in 122 patients with pancreatoduodenectomy, including 48 patients aged over 70 years, and reported no significant difference between older group and younger group comparing the rate of complications, such as wound infection, abdominal abscess, pancreatic leak, and so on. A retrospective study carried out on 97 patients with a gastric tumor measuring 10 cm or more in diameter showed age was not the influencing factor of frequency of complications [5] .…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggested that elderly surgical patients had high morbidity and mortality [3,4] . Other reports showed that there was no significant difference in the rate of complications and death between the older and the younger surgical patients [5,6] . Two hundreds and eleven patients undergone major abdominal operations, including hepatectomy, gastrectomy and pancreatoduodenectomy in recent 5 years were analyzed retrospectively to see whether the older patients face more risks than younger patients.…”

Section: Introductionmentioning

confidence: 91%

Safe major abdominal operations: Hepatectomy, gastrectomy and pancreatoduodenectomy in elder patients

Yu²,

Xu³

2004

WJG

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AIM:To evaluate the impact of advanced age on outcome after hepatectomy, gastrectomy and pancreatoduodenectomy. METHODS:Two hundreds and eleven patients undergone hepatectomy, gastrectomy and pancreatoduodenectomy from January 1998 to September 2002 were analyzed retrospectively. Clinicopathologic features and operative outcome of 83 patients aged 65 years or more were compared with that in 128 younger patients aged less than 65 years. RESULTS:The nutritional state, such as pre-operation level of serum albumin and hemoglobin in the older patients was poorer than that in the younger patients. The older patients had higher comorbidities than the younger patients (48.2% vs 15.6%). No significant difference was observed in perioperative mortality, and complication rate between the older and younger patients (2.4% vs 1.6% and 22.9% vs 20.3%, respectively). Multivariate analysis demonstrated that pancreatoduodenectomy, hepatectomy with resection of more than 2 segments and comorbidities were independent predictors of postoperative complication, whereas age was not (P=0.3172). CONCLUSION:It is safe for patients aged 65 years or more to undergo hepatic, pancreatic and gastric resection if great care is taken during perioperative period.Wu YL, Yu JX, Xu B. Safe major abdominal operations: Hepatectomy, gastrectomy and pancreatoduodenectomy in elder patients. World

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Age is not a contraindication to pancreaticoduodenectomy

Cited by 44 publications

References 0 publications

Age does not affect complications and overall survival rate after pancreaticoduodenectomy: Single-center experience and systematic review of literature

Age does not affect complications and overall survival rate after pancreaticoduodenectomy: Single-center experience and systematic review of literature

Should We Deny Surgery for Malignant Hepato‐Pancreatico‐Biliary Tumors to Elderly Patients?

Safe major abdominal operations: Hepatectomy, gastrectomy and pancreatoduodenectomy in elder patients

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