Age Is a Greater Influence on Small Saccades Than Target Size in Normal Subjects on the Horizontal Video Head Impulse Test

Jay, David R.; Cane, Debbie; Howe, Simon

doi:10.3389/fneur.2019.00328

Cited by 11 publications

(29 citation statements)

References 58 publications

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“…Another reason for inaccurate CSs could be, in contrast to what was assumed, the fixation target was not a point but had a spatial spread, and a saccade that brought the fovea to some location within the target region could be good enough. 24…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Saccade Gain in Video Head Impulse Testing

Wang

et al. 2020

Otolaryngol.--head neck surg.

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Objective To quantitatively analyze corrective saccade (CS) gain and further characterize the specific relationship between vestibulo-ocular reflex (VOR) gain and CS gain in patients with vestibular loss and healthy controls. Study Design Prospective combined with retrospective study. Setting Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University. Subjects and Methods Forty patients with unilateral vestibular loss and 40 participants with normal vestibular function were subjected to video head impulse testing (vHIT). The analysis of the horizontal semicircular canal VOR and CS gains was based on individual head impulses. Results The patient group had significantly higher CS gain and lower VOR gain than the control group ( P < .001). While there was no significant correlation between VOR and CS gains in the control group after adjusting for age and sex ( P = .689), VOR gain negatively correlated with CS gain in the patient group ( r = −0.853, P < .001). The specific relationship between VOR and CS gains was characterized as y = −1.17x + 1.12 (x: VOR gain, y: CS gain; r 2 = 0.732, P < .001) in the patient group. Conclusions In healthy participants, CS was not correlated with VOR gain, suggesting that CS is not due to VOR hypofunction. In patients with unilateral vestibular loss, CS was closely associated with VOR gain and can almost correct gaze position errors required for visual stabilization. CS gain could be an important indicator to diagnose vestibular loss and help physicians identify abnormal vHIT curves caused by artifacts and irregular practices.

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Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Saccade Gain in Video Head Impulse Testing

Wang

et al. 2020

Otolaryngol.--head neck surg.

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“…13,14 Indeed, in our study, the canal response was statistically worse in the elderly, probably due to the loss of inner ear function from underlying pathology coupled with aging process, 15 conse-quently they demonstrated a lesser improvement in DHI scores compared with younger patients. A recent study 16 showed a significant correlation between age and VOR gain, the saccade profile of normal subjects on the horizontal VHIT. Moreover, both the cVEMP and oVEMP tests show an age-related deterioration in the corresponding neural functions.…”

Section: Discussionmentioning

confidence: 94%

Vestibular Neuritis in Patients Among Different Age Groups: Clinical Features and Outcomes

et al. 2020

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Background Patients with vestibular neuritis (VN) displayed differential prognosis despite of the same treatment. Thus, identifying unique characteristics in different populations and creating individually customized treatments are necessary. However, studies about the clinical features according to different ages are scarce. Purpose This article compares the differences in VN patients among different age groups. Research Design A prospective study. Study Sample A total of 70 VN patients were enrolled in the present study. Intervention All the patients started vestibular rehabilitation at the time of initial presentation to our clinic. They were followed up at 1-month intervals using the questionnaire until 4 months. Data Collection and Analysis Patients' clinical data including clinical presentation, vestibular testing results, treatment, and recovery was collected and analyzed with Duncan's multiple range test, the sign test, and the Kruskal–Wallis test using SPSS18.0. Results The mean age of the 70 patients was 47.2 ± 17.1, ranging from 10 to 76 years old. The sex ratios (male:female) were 3.5 in the adolescent group, 0.643 in the young adult group, 1.375 in the middle-aged group, and 0.583 in the senior group. The prevalence of hypertension and diabetes mellitus showed a significantly increasing trend from young adults to the seniors (p < 0.05). The caloric response was statistically worse in the senior group than the other groups (p < 0.05). The abnormal rates for video head impulse test, vestibular-evoked myogenic potential, and vestibular autorotation test did not differ significantly in different age groups. A significant difference between prerehabilitation and postrehabilitation total Dizziness Handicap Inventory (DHI) scores was identified in all the groups (p < 0.05). The younger patients demonstrated a greater improvement than patients in the senior group, meanwhile adolescents improved the most (p < 0.05). Hospital Anxiety and Depression Scale (HADS) was the lowest in the adolescent group (p < 0.05). DHI score at acute stage was significantly correlated with HADS (r = 0.597, p < 0.05). Conclusion The canal response was statistically better for younger patients compared with the elderly. The younger patients demonstrated a greater improvement than patients in the senior group, among whom adolescents improved the most, meanwhile psychological factors played a minor role in adolescents. Self-perceived disability-handicap positively correlated with anxiety and depression in all patients.

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“…An earlier timing [ 34 , 35 ] and a higher level of grouping (clustering regarding timing, quantified using the PR-score) of saccades might be indicative of compensation and might be correlated with a lower handicap in patients with vestibular hypofunction [ 36 – 40 ]. However, corrective saccades do not only reflect clinically relevant vestibular hypofunction or compensatory mechanisms: small saccades also appear in healthy subjects, especially with increasing age [ 41 ].…”

Section: The Video-head Impulse Test (Vhit)mentioning

confidence: 99%

Diagnosing vestibular hypofunction: an update

et al. 2020

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Unilateral or bilateral vestibular hypofunction presents most commonly with symptoms of dizziness or postural imbalance and affects a large population. However, it is often missed because no quantitative testing of vestibular function is performed, or misdiagnosed due to a lack of standardization of vestibular testing. Therefore, this article reviews the current status of the most frequently used vestibular tests for canal and otolith function. This information can also be used to reach a consensus about the systematic diagnosis of vestibular hypofunction.

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Age Is a Greater Influence on Small Saccades Than Target Size in Normal Subjects on the Horizontal Video Head Impulse Test

Cited by 11 publications

References 58 publications

Quantitative Analysis of Saccade Gain in Video Head Impulse Testing

Quantitative Analysis of Saccade Gain in Video Head Impulse Testing

Vestibular Neuritis in Patients Among Different Age Groups: Clinical Features and Outcomes

Diagnosing vestibular hypofunction: an update

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