Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer

Neven, Patrick; Calster, Ben Van; Bempt, I. Van den; Huffel, Sabine Van; Belle, Vanya Van; Hendrickx, Wouter; Decock, Julie; Wildiers, Hans; Paridaens, Robert; Amant, Frédéric; Leunen, Karin; Berteloot, Patrick; Timmerman, D.; Limbergen, Erik; Weltens, Caroline; Bogaert, Walter Van den; Smeets, Ann; Vergote, Ignace; Christiaens, Melissa; Drijkoningen, Maria

doi:10.1007/s10549-007-9687-4

Cited by 13 publications

(10 citation statements)

References 26 publications

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“…Our observed associations with age are in accordance with the findings in the literature for Caucasian women [39]. At a higher age, tumors are more often ER positive [39,40,41,42]. In the study by Parise et al [39], the increase in the percentage of the ER + /PR + /HER2 - subtype with increasing age almost mirrored the increasing proportion of BC cases in white women [39].…”

Section: Discussionsupporting

confidence: 91%

Impact of Body Mass Index on Prognostically Relevant Breast Cancer Tumor Characteristics

Eichholzer

Huang²,

Modlasiak³

et al. 2013

Breast Care

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Background: This study analyzes the association of body mass index (BMI) and prognostically relevant breast cancer (BC) characteristics in a country that has been rather spared of the global obesity epidemic. Patients and Methods: Based on 20-year data (1999-2009, n = 1,414) of the prospective relational BC database of the University Hospital Basel, Switzerland, the associations between BMI, tumor size and stage, histological subtype, grading, hormonal receptor status, HER2 status and ‘triple-negative' status were evaluated. Multivariate analysis considered BMI and patient's age. Results: The association between increasing BMI and the above-mentioned variables were as follows (results described in each case: Beta-coefficient or odds ratio, 95% confidence interval, p value): tumor size, (1) entire cohort: 0.03 (0.01-0.05), p < 0.001, (2) tumor found by self-palpation: 0.05 (0.03-0.07), p < 0.001, (3) tumor found by radiological examination: 0.03 (0-0.07), p = 0.044; advanced TNM stage: 1.16 (1.02-1.31), p = 0.022; histological subtype: 1.04 (0.89-1.22), p = 0.602; unfavorable grading: 1.11 (1.00-1.25), p = 0.057; positive estrogen receptor status: 0.95 (0.83-1.09), p = 0.459; positive HER2 status: 0.92 (0.74-1.15), p = 0.467; presence of a ‘triple-negative' carcinoma: 1.19 (0.93-1.52), p = 0.165. Consideration of only postmenopausal BC patients (n = 1,063) did attenuate the results, but did not change the direction of the associations with BMI. Conclusion: BMI was positively associated with TNM stage, grading and tumor size for tumors that were found by self-detection, as well as for those lesions detected by radiological breast examinations.

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Section: Discussionsupporting

confidence: 91%

Impact of Body Mass Index on Prognostically Relevant Breast Cancer Tumor Characteristics

Eichholzer

Huang²,

Modlasiak³

et al. 2013

Breast Care

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“…Results reported in this study were based only on an IHC score of >0. Positivity for psoriasin/S100A7 (a marker that correlates with indicators of poor prognosis) and CK5/6 (one of the markers of basal phenotype) was set at >0, for Ki67 at >30 (corresponding to the median of the ER− TMA), whereas for EGFR and HER‐2, only breast cancers that showed strong, intense membranous immunopositivity of IHC 3+ (>30% of invasive tumour cells) were considered positive, as reported, used and recommended by other groups 32–34 …”

Section: Methodsmentioning

confidence: 99%

Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancers

et al. 2008

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Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancersAims: Small breast epithelial mucin (SBEM) is a recently described gene product that shows promise as a new breast biomarker. The aim was to investigate for the first time SBEM protein expression in a large cohort (n = 300) of invasive breast cancers, its relationship to established clinical variables and its association with clinical outcome. Methods and results: Immunohistochemical analysis was performed on tissue microarrays consisting of 149 oestrogen receptor (ER) a) and 151 ERa+ breast cancers. Overall, 18% of tumours were SBEM+ (n = 53 ⁄ 300). However, SBEM protein was more frequently observed in ER) (22%) than in ER+ cancers (13%; P = 0.049). A significant association with psoriasin ⁄ S100A7 expression (P £ 0.0001) was observed in the entire cohort. SBEM was also positively associated with HER-2 (P = 0.046) in ER) cancers, and increased levels of SBEM were strongly associated with higher tumour grade (P = 0.0015). Furthermore, SBEM expression showed a trend towards an association with reduced overall survival and relapse-free survival in the ER+ cohort (P = 0.063 and P = 0.072, respectively). Conclusions: Our results suggest that SBEM may identify a unique subset of breast cancers with poor prognosis and may have future implications for therapeutic management of this disease.

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“…Histology and multifocal disease were analyzed as dichotomous variables, the combined receptor status as six-level categorical. Determination of tumor grading and ER, PR, and HER-2/neu status was done according to established procedures, which have been described in more detail elsewhere [8]. A breast cancer was allocated to the lobular subtype if more than 90% of the tumor mass harboured morphological features of the lobular type; this was always confirmed by lack of E-cadherin expression.…”

Section: Variables Studiedmentioning

confidence: 99%

Lobular and non-lobular breast cancers differ regarding axillary lymph node metastasis: a cross-sectional study on 4,292 consecutive patients

Vandorpe

Smeets

Calster

et al. 2011

Breast Cancer Res Treat

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Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer

Abstract: There is a qualitative interaction between age and expression of steroid and HER-2 receptors. Our findings suggest a strong age-related selective growth advantage for breast tumour cells belonging to the ER+PR+HER-2+ subgroup.

Cited by 13 publications

References 26 publications

Impact of Body Mass Index on Prognostically Relevant Breast Cancer Tumor Characteristics

Impact of Body Mass Index on Prognostically Relevant Breast Cancer Tumor Characteristics

Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancers

Lobular and non-lobular breast cancers differ regarding axillary lymph node metastasis: a cross-sectional study on 4,292 consecutive patients

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