Age Influence on the Immune System

Makinodan, Takashi; Kay, Marguerite M. B.

doi:10.1016/s0065-2776(08)60047-4

Cited by 643 publications

(216 citation statements)

References 211 publications

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“…Although we did not observe any age-related alteration of telomerase induction in lymphocyte subsets after short term stimulation, it is not clear whether or not sustained induction of telomerase activity changes with age. Previous reports have shown an age-associated increase of activationinduced apoptosis (40 -42) and changes in subset composition (3,43) and in immune functions (1). It is possible that some of these age-related factors may affect the sustained expression of telomerase in lymphocytes during long term culture or in vivo.…”

Section: Figurementioning

confidence: 97%

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Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age

Son

Murray

Yanovski

et al. 2000

The Journal of Immunology

184

147

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Age effects on telomere length and telomerase expression in peripheral blood lymphocytes were analyzed from 121 normal individuals age newborn to 94 years and revealed several new findings. 1) Telomere shortening was observed in CD4+ and CD8+ T and B cells with age. However, the rate of telomere loss was significantly different in these populations, 35 ± 8, 26 ± 7, and 19 ± 7 bp/year for CD4+ and CD8+ T and B cells, respectively. In addition, CD4+ T cells had the longest average telomeres at all ages, followed by B cells, with CD8+ T cell telomeres the shortest, suggesting that these lymphocyte populations may have different replicative histories in vivo. 2) Telomerase activity in freshly isolated T and B cells was indistinguishably low to undetectable at all ages but was markedly increased after Ag and costimulatory receptors mediated stimulation in vitro. Furthermore, age did not alter the magnitude of telomerase activity induced after stimulation of T or B lymphocytes through Ag and costimulatory receptors or in response to PMA plus ionomycin treatment. 3) The levels of telomerase activity induced by in vitro stimulation varied among individual donors but were highly correlated with the outcome of telomere length change in CD4+ T cells after Ag receptor-mediated activation. Together, these results indicate that rates of age-associated loss of telomere length in vivo in peripheral blood lymphocytes is specific to T and B cell subsets and that age does not significantly alter the capacity for telomerase induction in lymphocytes.

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Section: Figurementioning

confidence: 97%

“…T he impact of aging on immune function is well documented (1). At the cellular level, evidence suggests that aging is associated with decreases in the numbers of circulating CD4 ϩ T and B lymphocytes in peripheral blood (2) and with changes in composition of T lymphocyte subsets (3).…”

mentioning

confidence: 99%

Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age

Son

Murray

Yanovski

et al. 2000

The Journal of Immunology

184

147

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“…The dysregulation of immune function with ageing is well established (94,95); it contributes to higher incidence of, and increased morbidity and mortality from, cancer and infectious autoimmune and neoplastic diseases (91,92). A large part of the overall decline is made up of decreases in T cell-mediated function, including thymus involution and in vivo decreases in DTH response; the graft-versus-host reaction; resistance to tumours, viruses and parasites; T cell-dependent primary and secondary antibody responses; and the proportion of T cell subsets with naive cell surface markers (93).…”

Section: Immune Functionmentioning

confidence: 99%

The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

Raman

Pal

Ganesan

et al. 2016

Eye

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“…It is well established that aging individuals suffer from a decline in their natural as well as adaptive immune functions (Haughton & Whitmore, 1978;Makinodan & Kay, 1980;Tyan, 1981). The concurrence of decreased immune reactivity and the high incidence of tumours in old individuals raises the possibility that the deterioration of the general immune status is causally related to the increased risk of developing spontaneous neoplasms with advanced age (Keast, 1970).…”

mentioning

confidence: 99%

“…Some forms of immunological decline can be restored by adoptive transfer into old animals of immunocytes from young ones (Makinodan & Kay, 1980). In most cases however, spontaneous tumour development in old animals was not inhibited or delayed by administration of immune competent cells from young donors.…”

mentioning

confidence: 99%

B16 melanoma development, NK activity cytostasis and natural antibodies in 3 and 12 month old mice

Ehrlich¹,

Smorodinsky²,

Efrati³

et al. 1984

Br J Cancer

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Summary Three types of natural immune responses against malignant cells were studied in vitro: Cytotoxicity mediated by splenic NK cells; cytostasis mediated by splenocytes and binding of naturally occurring antibodies to various tumour targets. These responses were studied in untreated 3 and 12 month old mice and in mice of both age groups inoculated with B16 melanoma cells. The results showed that in normal mice NK activity decreases with age, cytostatic activity remains unchanged and the titre of natural antibodies increases.Twelve-month old mice were shown to be appreciably more resistant than 3 month old mice to the development of tumours from subthreshold numbers of B16 tumour cells.In mice injected with threshold amounts of the B16 tumour, there was no change in any of the responses in the tumour-free period, but there was a decrease in NK activity and an increase in cytostatic activity when a large tumour mass developed. An increase in the titre of natural antibodies in young mice injected with the tumour was also seen. The correlation between these changes and tumour appearance and development is discussed.

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Age Influence on the Immune System

Cited by 643 publications

References 211 publications

Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age

Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age

The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

B16 melanoma development, NK activity cytostasis and natural antibodies in 3 and 12 month old mice

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