Age effect on hearing: A study on Japanese.

Tsuiki, Takashi; Sasamori, Shirou; Minami, Yoshinori; Ichinohe, Takakatsu; Murai, Kazuo; Murai, S.; Kawashima, Hiroshi

doi:10.4295/audiology.45.241

Cited by 22 publications

(15 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in line with a previous study [19]. Although the sexual difference of BC hearing is still controversial [20,21], the majority of studies have reported that male BC thresholds are worse than female BC thresholds, particularly at high frequencies [22][23][24].…”

Section: Discussionsupporting

confidence: 91%

Is sensorineural hearing loss with chronic otitis media due to infection or aging in older patients?

2009

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 91%

Is sensorineural hearing loss with chronic otitis media due to infection or aging in older patients?

2009

View full text Add to dashboard Cite

“…Detailed neuro-otological examinations, including pure-tone audiometry, were performed on 13 families at the Departments of Neurology and Otolaryngology, Tokyo Medical and Dental University. Progressive hearing impairment was assessed when the pure-tone average calculated from thresholds at the frequencies of 0.5, 1, and 2 kHz was more severe than the mean ϩ2 SD of age-matched normal Japanese population (Tsuiki et al 2002). By that criterion, 6 (42.9%) of 14 families had a hearing impairment other than age-related hearing loss.…”

Section: Recruitment Of Families With Chromosome 16q221-linked Adcamentioning

confidence: 99%

An Autosomal Dominant Cerebellar Ataxia Linked to Chromosome 16q22.1 Is Associated with a Single-Nucleotide Substitution in the 5′ Untranslated Region of the Gene Encoding a Protein with Spectrin Repeat and Rho Guanine-Nucleotide Exchange-Factor Domains

Ishikawa

Toru

Tsunemi

et al. 2005

The American Journal of Human Genetics

122

139

View full text Add to dashboard Cite

Autosomal dominant cerebellar ataxia (ADCA) is a group of heterogeneous neurodegenerative disorders. By positional cloning, we have identified the gene strongly associated with a form of degenerative ataxia (chromosome 16q22.1-linked ADCA) that clinically shows progressive pure cerebellar ataxia. Detailed examination by use of audiogram suggested that sensorineural hearing impairment may be associated with ataxia in our families. After restricting the candidate region in chromosome 16q22.1 by haplotype analysis, we found that all patients from 52 unrelated Japanese families harbor a heterozygous C-->T single-nucleotide substitution, 16 nt upstream of the putative translation initiation site of the gene for a hypothetical protein DKFZP434I216, which we have called "puratrophin-1" (Purkinje cell atrophy associated protein-1). The full-length puratrophin-1 mRNA had an open reading frame of 3,576 nt, predicted to contain important domains, including the spectrin repeat and the guanine-nucleotide exchange factor (GEF) for Rho GTPases, followed by the Dbl-homologous domain, which indicates the role of puratrophin-1 in intracellular signaling and actin dynamics at the Golgi apparatus. Puratrophin-1--normally expressed in a wide range of cells, including epithelial hair cells in the cochlea--was aggregated in Purkinje cells of the chromosome 16q22.1-linked ADCA brains. Consistent with the protein prediction data of puratrophin-1, the Golgi-apparatus membrane protein and spectrin also formed aggregates in Purkinje cells. The present study highlights the importance of the 5' untranslated region (UTR) in identification of genes of human disease, suggests that a single-nucleotide substitution in the 5' UTR could be associated with protein aggregation, and indicates that the GEF protein is associated with cerebellar degeneration in humans.

show abstract

“…While many hearing-sensitivity studies sampling hundreds to thousands of different-aged subjects have provided much insight into sex- and age-specific hearing loss [14] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [31] , these studies used different hearing-test parameters (e.g., range of frequencies) and hearing-loss definitions [24] . Moreover, some studies sampled only individuals older than 48 years [17] , which makes it impossible to determine when hearing-thresholds first deteriorate.…”

Section: Introductionmentioning

confidence: 99%

Patterns of hearing changes in women and men from denarians to nonagenarians

Wasano

Kaga

Ogawa

2021

The Lancet Regional Health - Western Pacific

View full text Add to dashboard Cite

Background: Hearing loss needs to be diagnosed and treated early, especially in older individuals, since presbycusis potentially increases the risk of depression and dementia. However, standard data on hearing thresholds across the life-span in Japanese individuals are lacking.Methods: In a retrospective consecutive sample of 10681 native-Japanese speakers (37.3% men; 10-99 years; left-right hearing threshold difference of < 15 dB for all tested pure tones; free of external, middle, or inner ear disease), we determined standard age-decade and sex-specific pure-tone air-conduction (125, 250, 500, 1000, 2000, 4000, and 8000 Hz) hearing threshold norms. The main outcome measures were pure-tone averages for both ears by age-decade and sex.Findings: For participants in their 20s, hearing thresholds at higher frequencies ( > 10 0 0 Hz) were significantly worse in men than in women. For participants ≥70 years, hearing thresholds at low frequencies were higher in women. Hearing thresholds at 10 0 0, 20 0 0, and 40 0 0 Hz tended to deteriorate, starting in the teenage years through the 50s, with some decades showing significantly worse decline. Sex differences were absent in the youngest and oldest groups.Interpretation: Standard age-and sex-specific audiometric data reported here for Japanese individuals over nine age-decades are based on the largest dataset analyzed to date. While hearing thresholds of men and women in the very young and the very old age groups were indistinguishable in their cohorts, patterns of hearing changes for other age cohorts differed by direction and sex.

show abstract

Age effect on hearing: A study on Japanese.

Cited by 22 publications

References 7 publications

Is sensorineural hearing loss with chronic otitis media due to infection or aging in older patients?

Is sensorineural hearing loss with chronic otitis media due to infection or aging in older patients?

An Autosomal Dominant Cerebellar Ataxia Linked to Chromosome 16q22.1 Is Associated with a Single-Nucleotide Substitution in the 5′ Untranslated Region of the Gene Encoding a Protein with Spectrin Repeat and Rho Guanine-Nucleotide Exchange-Factor Domains

Patterns of hearing changes in women and men from denarians to nonagenarians

Contact Info

Product

Resources

About