Age distribution of Spitz nevus vs malignant melanoma

Herreid, Peter A.; Shapiro, P.

doi:10.1001/archderm.132.3.352

Cited by 45 publications

(13 citation statements)

References 4 publications

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“…In particular, our results are consistent with prior studies describing younger age at diagnosis for patients with Spitz nevi (mean age range: 18.8-22 years in published Iiterature 2, 6, 7, 8 ), compared with older age at diagnosis for patients with Spitzoid malignant melanoma, 2 confirming that Spitz nevi may arise in adults and children. 2, 6, 7, 8, 9, 10, 13 Like prior case series of Spitz nevi, we also found predominance of these lesions in female patients, 6, 7, 8, 9, 10 which were also more likely to be smaller in size compared with Spitzoid malignant melanomas. In our study the most common histopathologic type of Spitz nevi was compound, followed by intradermal and junctional.…”

Section: Discussionsupporting

confidence: 92%

“…1, 2, 3, 4, 5 Spitzoid malignant melanomas are melanomas bearing histologic resemblance to Spitz nevi. Unified interpretation of histopathologic criteria and clinical characteristics for distinguishing these lesions are lacking.…”

mentioning

confidence: 99%

“…2, 6, 7, 8, 9, 10 To date, however, most clinicopathologic studies of Spitz nevi and Spitzoid malignant melanomas have been restricted to case reports and small case series of limited generalizability with very few large studies, 2, 6, 7, 8, 9, 10 constraining our ability to confidently identify clinical features significantly associated with Spitz nevus versus Spitzoid malignant melanoma diagnoses. Given this knowledge gap, there is a need to leverage larger cohorts of patients with Spitz nevi and Spitzoid malignant melanomas to characterize both potential patient- and tumor-level factors that may assist in classification of these lesions.…”

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confidence: 99%

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Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: The Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008

Lott

Wititsuwannakul

Lee

et al. 2014

Journal of the American Academy of Dermatology

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Background Spitz nevi and Spitzoid malignant melanomas are uncommon and may be difficult to distinguish histopathologically. Identification of clinical features associated with these lesions may aid in diagnosis. Objective We sought to identify clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas. Methods We conducted a retrospective cohort study of Spitz nevi and Spitzoid malignant melanomas from the Yale University Spitzoid Neoplasm Repository diagnosed from years 1991 through 2008. Descriptive statistics and multivariate logistic regression were used to compare select patient- and tumor-level factors associated with each lesion. Results Our cohort included 484 Spitz nevi and 54 Spitzoid malignant melanomas. Spitz nevi were more common (P = .03) in females (65%; n = 316) compared with Spitzoid malignant melanomas (50%; n = 27), occurred more frequently in younger patients (mean age at diagnosis 22 vs 55 years; P < .001), and more likely presented as smaller lesions (diameter 7.6 vs 10.5 mm; P < .001). Increasing age (odds ratio 1.16, 95% CI [1.09, 1.14]; P< .001) and male gender (odds ratio 2.77, 95% CI [1.17, 6.55]; P< .02) predicted Spitzoid malignant melanoma diagnosis. Limitations Small sample size, unmeasured confounding, and restriction to a single institution may limit the accuracy and generalizability of our findings. Conclusions Age and gender help predict diagnosis of Spitz nevi and Spitzoid malignant melanomas.

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%

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confidence: 99%

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Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: The Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008

Lott

Wititsuwannakul

Lee

et al. 2014

Journal of the American Academy of Dermatology

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“…The only reliable way to distinguish Spitz‐like melanoma from atypical Spitz tumor is by the occurrence of widespread metastases. The age of the patient was proposed as the only differential diagnostic criterion by some authors (12,13). Although Spitz‐like melanoma is very rare during the first decade of life, atypical tumors with Spitzoid features still have the possibility of metastasis, even in this age group (14).…”

Section: Discussionmentioning

confidence: 99%

A Current Dilemma in Histopathology: Atypical Spitz Tumor or Spitzoid Melanoma?

Gürbüz

Apaydın

Müezzínoğlu

et al. 2002

Pediatric Dermatology

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Both clinically and histopathologically, melanoma of childhood is a rarely encountered lesion. In addition, it has particular histopathologic diagnostic problems. Differential diagnosis of this lesion and Spitz nevus is at times very problematic, in that distant metastases and death of the patient may be the only diagnostic criteria for some cases. We present a 4-year-old girl with an atypical melanocytic neoplasm with Spitzoid features on the left subscapular region.

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“…Spitz nevi are more common in children but can arise throughout life. They typically present as skin-colored, pink, brown or black dome shaped lesions that may regress over time 8 . While they most commonly occur as solitary lesions, they can occasionally present in an agminated (grouped) or disseminated fashion.…”

Section: Introductionmentioning

confidence: 99%

Eruptive Spitz nevus, a striking example of benign metastasis

Raghavan

Kapler

Dinges

et al. 2020

Sci Rep

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Metastasis is generally considered a characteristic of malignant tumors. Herein, we describe a patient with more than one hundred discrete Spitz nevi scattered all over her skin. Molecular analysis from three of the lesions identified a ROS1 fusion oncogene with identical genomic breakpoints, indicating that the nevi arose from a single transformed melanocyte and then disseminated throughout the integument. The demonstration of widespread distribution of a benign tumor with limited proliferative capability indicates that metastatic dissemination is not contingent on full malignant transformation. Thus, eruptive Spitz nevus is a striking example of benign metastasis, demonstrating that metastasis can occur before malignant transformation.

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Age distribution of Spitz nevus vs malignant melanoma

Cited by 45 publications

References 4 publications

Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: The Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008

Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: The Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008

A Current Dilemma in Histopathology: Atypical Spitz Tumor or Spitzoid Melanoma?

Eruptive Spitz nevus, a striking example of benign metastasis

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