Age distribution and outcomes in patients undergoing breast cancer resection in Saudi Arabia

Alabdulkarim, Balqis; Hassanain, Mazen; Bokhari, Areej; Alsaif, Abdulaziz; Alkarji, Hana

doi:10.15537/smj.2018.5.21993

Cited by 17 publications

(33 citation statements)

References 21 publications

(38 reference statements)

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“…However, it has served the purpose of providing primary data, which is comparable with similar recent and historical studies. The patterns of incidence and mortality rates for breast cancer vary across countries and are attributable to a combination of demographic, heredity, environmental, and lifestyle factors [7]. In developing countries, the incidence of breast cancer is increasing and is becoming more similar to developed countries [7].…”

Section: Discussionmentioning

confidence: 99%

“…The patterns of incidence and mortality rates for breast cancer vary across countries and are attributable to a combination of demographic, heredity, environmental, and lifestyle factors [7]. In developing countries, the incidence of breast cancer is increasing and is becoming more similar to developed countries [7]. Although, at present, the incidence of breast cancer in developed countries remains higher, mortality is lower [7].…”

Section: Discussionmentioning

confidence: 99%

“…In developing countries, the incidence of breast cancer is increasing and is becoming more similar to developed countries [7]. Although, at present, the incidence of breast cancer in developed countries remains higher, mortality is lower [7]. Several factors, including late presentation, may explain this, as the disease stage at diagnosis is strongly associated with patient outcomes [7].…”

Section: Discussionmentioning

confidence: 99%

“…Current guidelines from the Saudi Center of Evidence-Based Healthcare recommend starting screening with mammography at the age of 40, five years younger than the American Cancer Society guidelines [7]. This recommended age was chosen by the Saudi expert panel based on the increased incidence of breast cancer in patients aged 40-49 years as compared with other countries [8][9].…”

Section: Discussionmentioning

confidence: 99%

“…Although the average age of diagnosis falls within this age group (40-49 years), 20% of our study population was younger and would not have been diagnosed with screening. Furthermore, the application of these guidelines has been limited, as indicated by another study that found that almost 92% of women over 50 have never undergone screening [7]. According to current guidelines, patients aged >40 years should undergo mammography every one or two years.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Incidence Rates of Breast Cancer by Age and Tumor Characteristics Among Saudi Women: Recent Trends

Asiri¹,

Asiri²,

Ulahannan³

et al. 2020

Cureus

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Introduction and objectives With such a huge country as Saudi Arabia, it would be expected to have variations in the pattern and incidence of breast diseases. This study aims to determine the recent trends in breast cancer incidence rates by age and tumor characteristics among female patients treated in the Armed Forces Hospital Southern Region (AFHSR) from the period of January 2010 to December 2017. Methods This study is a retrospective chart review where all breast biopsy reports of female patients were seen between January 2010 and December 2017 at the AFHSR, Saudi Arabia, to observe the pattern of breast cancer as well as to calculate the incidence rates by age and tumor characteristics among the study subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Incidence Rates of Breast Cancer by Age and Tumor Characteristics Among Saudi Women: Recent Trends

Asiri¹,

Asiri²,

Ulahannan³

et al. 2020

Cureus

View full text Add to dashboard Cite

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Targeted sequencing of crucial cancer causing genes of breast cancer in Saudi patients

Alanazi

Parine

Shaik

et al. 2020

Saudi Journal of Biological Sciences

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Breast cancer is the most common cancer among women worldwide, causing 15% of cancer-related deaths among women. Breast cancer incidence rate is increasing in most countries. In Saudi Arabia, breast cancer constitutes nearly 22% of the newly diagnosed cancer cases in women. Breast cancer incidence in the women population of Saudi Arabia is 25.9%, with 18.2% mortality. In this study, targeted sequencing of 164 selected genes was performed on germline and somatic DNA derived from the blood and tissue samples of 50 breast cancer patients using customized panel on Ion torrent platform. This study focused on the identification of genetic variations of different cancer-causing genes, raising the hope for identification of personalized prognosis. After final filtration and validation, we found protein-truncating, non-synonymous missense, and splice site mutations in the known susceptibility genes for breast cancer. We identified a total of 14 point mutations and one deletion in BRCA1 , BRCA2 , and RAD50 genes from the BRCA panel analysis of breast cancer samples. In the customized panel analysis, we identified 37 potential mutations in 25 breast cancer risk associated genes. Out of these, most mutations were observed in TP53. After filtration, we observed 7 mutations in TP53 genes (n = 7:- one stop gain (p.R81X), four non-synonymous (p.R81X, p.Y88C, p.R141H, and p.V25D), and two deletions (c.59delC and c.327delC)). Among the mutations detected in our study, TP53 (p.R81X), VHL (p.E52X), and BRCA2 (p.K3326X) mutations, which lead to an aberrant transcript with a premature stop codon, were reported for the first time in breast cancer patients from Saudi Arabia. Our study will help in identifying the damaging mutations and predisposing genes in Saudi breast cancer patients.

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Identification and characterization of ATM founder mutation in BRCA-negative breast cancer patients of Arab ethnicity

Bu,

Siraj,

Al-Rasheed

et al. 2023

Sci Rep

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Breast cancer (BC) is the most prevalent malignancy among women worldwide with germline pathogenic variants/likely pathogenic variants (PVs/LPVs) in BRCA1/2 accounting for a large portion of hereditary cases. Recently, heterozygous PVs/LPVs in the ATM serine/threonine kinase or Ataxia-telangiectasia mutated gene (ATM) has been identified as a moderate susceptibility factor for BC in diverse ethnicities. However, the prevalence of ATM PVs/LPVs in BC susceptibility in Arab populations remains largely unexplored. This study investigated the prevalence of ATM PVs/LPVs among BC patients from Saudi Arabia, employing capture-sequencing technology for ATM PVs/LPVs screening in a cohort of 715 unselected BC patients without BRCA1/2 PVs/LPVs. In addition, founder mutation analysis was conducted using the PHASE program. In our entire cohort, four unique PVs/LPVs in the ATM gene were identified in six cases (0.8%). Notably, one recurrent LPV, c.6115G > A:p.Glu2039Lys was identified in three cases, for which haplotype analysis confirmed as a novel putative founder mutation traced back to 13 generations on average. This founder mutation accounted for half of all identified mutant cases and 0.4% of total screened cases. This study further reveals a significant correlation between the presence of ATM mutation and family history of BC (p = 0.0127). These findings underscore an approximate 0.8% prevalence of ATM germline PVs/LPVs in Arab BC patients without BRCA1/2 PVs/LPVs and suggest a founder effect of specific recurrent ATM mutation. These insights can help in the design of a genetic testing strategy tailored to the local population in Saudi Arabia, thereby, enabling more accurate clinical management and risk prediction.

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Age distribution and outcomes in patients undergoing breast cancer resection in Saudi Arabia

Cited by 17 publications

References 21 publications

Incidence Rates of Breast Cancer by Age and Tumor Characteristics Among Saudi Women: Recent Trends

Incidence Rates of Breast Cancer by Age and Tumor Characteristics Among Saudi Women: Recent Trends

Targeted sequencing of crucial cancer causing genes of breast cancer in Saudi patients

Identification and characterization of ATM founder mutation in BRCA-negative breast cancer patients of Arab ethnicity

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