“…For example, using magnetic resonance imaging (MRI) scans, Gur et al (1991) observed that brain atrophy as indicated by increased cerebrospinal fluid volume with age was greater in males than in females; Cowell et al (1994) found greater age-related reductions in brain volume for both frontal and temporal lobes in males than in females; and Pruessner, Collins, Pruessner and Evans (2001) found a reduction in hippocampal volume across early adulthood for males but not for females. From such findings, it would be predicted that corresponding age by gender interactions would be found in behavioral data and, indeed, greater age-related cognitive decline in males than in females has been observed in both cross-sectional and longitudinal studies (e.g., Barrett-Connor & Kritz-Silverstein, 1999;Larrabee & Crook, 1993;Meyer et al, 1999;Rowe, Turcotte, & Hasher, 2004;Wiederholt et al, 1993;Zelinski & Stewart, 1998). Interestingly, similar results have been found in two studies of spatial memory in rhesus monkeys (Lacreuse et al, 2005;Lacreuse, Herndon, Killiany, Rosene, & Moss, 1999), suggesting that biological rather than sociocultural factors may underlie the gender differences in age-related decline.…”