Age Differences in Vestibular Brain Connectivity Are Associated With Balance Performance

Noohi, Fatemeh; Kinnaird, Catherine R.; Dios, Yiri De; Kofman, I. S.; Wood, Scott J.; Bloomberg, Jacob J.; Mulavara, Ajitkumar P.; Sienko, Kathleen H.; Polk, Thad A.; Seidler, Rachael D.

doi:10.3389/fnagi.2020.566331

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…These results might indicate that the static balance ability of the older adults with MCI standing on hard support surface was poorer compared to the older adults with normal cognition in the eyes open condition, which may be related to the significant changes in the white matter and the functional connectivity of Cortical Vestibular Network (CVN) [ 26 , 32 ]. A recent magnetic resonance imaging study showed that the CVN, a key brain region that integrates visual, auditory, and vestibular sensory information in older adults with MCI [ 33 ], was significantly correlated with their poorer balance function [ 32 ]. Its alterations might disrupt structural brain connectivity and interfere with neural pathways that control balance, resulting in the inability of the Central Nervous System (CNS) to effectively access or integrate sensory information, which may be the reason for the poorer balance in older adults with MCI [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

The static balance ability on soft and hard support surfaces in older adults with mild cognitive impairment

Qi,

Zhou,

Mao

et al. 2023

PLoS ONE

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Objective This study aimed to assess the static balance ability of the older adults with mild cognitive impairment (MCI) while standing on soft and hard support surfaces. Methods Forty older adults participated in this study (21 in the MCI group and 19 in the control group). Participants were required to perform balance tests under four conditions of standing: standing on a hard support surface with eyes open, standing on a soft support surface with eyes open, standing on a hard support surface with eyes closed, and standing on a soft support surface with eyes closed. Each test was measured in three trials and each trial lasted 30 seconds. Participants were asked to take off their shoes and place their feet in a parallel position with a 20-centimeter distance for bipedal support. The trajectories of the center of pressure (COP) were measured using a Kistler force platform with a frequency of 1000 Hz to assess balance while standing in both groups, with larger COP trajectories indicating poorer static balance in older adults. Results With eyes open, the displacement of COP in the anterior-posterior direction(D-ap) (hard support surface: P = 0.003) and the 95% confidence ellipse area(95%AREA-CE) (soft support surface: P = 0.001, hard support surface: P < 0.001) of the COP in the MCI group standing on hard and soft support surfaces were significantly larger than the control group. The 95%AREA-CE (P < 0.001) of the COP in the MCI group on the soft support surface was significantly larger than on the hard support surface. With eyes closed, the root mean square distance(RDIST), root mean square distance-ML(RDISTml), and 95%AREA-CE of the COP were no significant between-group differences when standing on hard support surfaces. However, the RDIST (P = 0.014), RDISTml (P = 0.014), and 95%AREA-CE (P = 0.001) of the COP in the MCI group on the soft support surfaces were significantly larger than the control group. The 95%AREA-CE (P < 0.001), RDIST (P < 0.001), and RDISTml (P < 0.001) of the COP in the MCI group on the soft support surface were significantly larger than the hard support surface. Conclusion With eyes open, the older adults with MCI showed poorer static balance ability compared to the older adults with normal cognition on soft and hard support surfaces. With eyes closed, the older adults with MCI showed poorer static balance on soft support surfaces, but no differences on hard support surfaces compared with the older adults with normal cognition. With eyes open and closed, the older adults with MCI showed poorer static balance on soft support surfaces as compared to hard support surfaces.

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Section: Discussionmentioning

confidence: 99%

The static balance ability on soft and hard support surfaces in older adults with mild cognitive impairment

Qi,

Zhou,

Mao

et al. 2023

PLoS ONE

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“…At rest, a pound of muscle that has not participated in TRX Suspension Trainer s requires 5-6 kcal per day for protein breakdown and synthesis, while a pound of muscle that HAS participated in TRX Suspension Trainer s requires approximately 9 kcal per day for protein breakdown and repair [10] . High-volume TRX Suspension Training (8 sets of 8 exercises) increased energy metabolism by 8-9%, 72 h after exercise.…”

Section: Trx Suspension Training and Energy Metabolismmentioning

confidence: 99%

“…The relevant parameters are walking ability cycle time, rhythm, stride length and leg range of motion. The average speed of an elderly person is 0.48 to 0.67 meters per second [10] . Elderly people often increase their walking speed by increasing stride frequency; in contrast, young people increase their stride length.…”

Section: Effect Of Trx Suspension Training On Walking Ability In the ...mentioning

confidence: 99%

Effect of TRX Suspension Training on Physical Function in Elderly Men with Sarcopenia

Zhang

2022

JCNR

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Elderly people have reduced muscle mass, decreased physical function and an increased hospitalization probability, which affect their quality of life and even lead to death in severe cases. Scholars at home and abroad have studied progressive body muscle loss associated with increase of age, decreased muscle strength and muscle function impairment syndrome and how to prevent them. Much research have been done preventing diseases and improving muscle strength through exercising, nutrition, and drug intervention, and these measures have been proven effective. This article describes the effect of exercising in reducing muscle disease, improving muscle mass, and physical abilities of the elderly. This study can not only effectively enrich the research results related to exercise therapy of sarcopenia, but is also in line with national strategies and policies such as the “national fitness campaign,” “Healthy China 2030 Plan Outline,” and “Healthy China Action 2019-2030” depending on the health conditions of the elderly population. Besides, this paper aims to develop individualized exercise programs, provide scientific basis for the prevention and treatment of sarcopenia in the elderly, reduce the risk of fall damage in the elderly, and promote the physical health level of the elderly.

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“…The connectome of parabrachial nuclei has been investigated only with task-based fMRI [Sklerov et al, 2019], thus, to our knowledge, our findings on their connectivity to the rest of the brain are original as well. For Ve, available literature of the vestibular network only reports the functional connectivity to the whole brainstem as a single node [Noohi et al, 2020] or to roughly divided brainstem macroregions [Kirsch et al, 2016]; thus, we consider our findings of Ve connectivity as original. The functional connectome of RMg has been investigated in [Bianciardi et al, 2016] and [Bär et al, 2016], which also report its connections to PAG and insula within the salience network.…”

Section: Noveltymentioning

confidence: 99%

Functional connectome of brainstem nuclei involved in autonomic, limbic, pain and sensory processing in living humans from 7 Tesla resting state fMRI

Singh

Stauder

García‐Gomar

et al. 2021

Preprint

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Despite remarkable advances in mapping the functional connectivity of the cortex, the functional connectivity of subcortical regions is understudied in living humans. This is the case for brainstem nuclei that control vital processes, such as autonomic, limbic, nociceptive and sensory functions. This is because of the lack of precise brainstem nuclei localization, of adequate sensitivity and resolution in the deepest brain regions, as well as of optimized processing for the brainstem. To close the gap between the cortex and the brainstem, on 20 healthy subjects, we computed a correlation based functional connectome of 15 brainstem nuclei involved in autonomic, limbic, nociceptive, and sensory function (superior and inferior colliculi, ventral tegmental area parabrachial pigmented nucleus complex, microcellular tegmental nucleus prabigeminal nucleus complex, lateral and medial parabrachial nuclei, vestibular and superior olivary complex, superior and inferior medullary reticular formation, viscerosensory motor nucleus, raphe magnus, pallidus, and obscurus, and parvicellular reticular nucleus alpha part) with the rest of the brain. Specifically, we exploited 1.1mm isotropic resolution 7 Tesla resting state fMRI, ad hoc coregistration and physiological noise correction strategies, and a recently developed probabilistic template of brainstem nuclei. Further, we used 2.5mm isotropic resolution resting state fMRI data acquired on a 3 Tesla scanner to assess the translatability of our results to conventional datasets. We report highly consistent correlation coefficients across subjects, confirming available literature on autonomic, limbic, nociceptive and sensory pathways, as well as high interconnectivity within the central autonomic network and the vestibular network. Interestingly, our results showed evidence of vestibulo autonomic interactions in line with previous work. Comparison of 7 Tesla and 3 Tesla findings showed high translatability of results to conventional settings for brainstem cortical connectivity and good yet weaker translatability for brainstem brainstem connectivity. The brainstem functional connectome might bring new insight in the understanding of autonomic, limbic, nociceptive and sensory function in health and disease.

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Age Differences in Vestibular Brain Connectivity Are Associated With Balance Performance

Cited by 6 publications

References 30 publications

The static balance ability on soft and hard support surfaces in older adults with mild cognitive impairment

The static balance ability on soft and hard support surfaces in older adults with mild cognitive impairment

Effect of TRX Suspension Training on Physical Function in Elderly Men with Sarcopenia

Functional connectome of brainstem nuclei involved in autonomic, limbic, pain and sensory processing in living humans from 7 Tesla resting state fMRI

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