Age differences in the neural systems supporting human allocentric spatial navigation

Moffat, Scott D.; Elkins, Wendy; Resnick, Susan M.

doi:10.1016/j.neurobiolaging.2005.05.011

Cited by 232 publications

(245 citation statements)

References 34 publications

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“…For both age groups, level of activation in hippocampus and parahippocampal gyrus was positively correlated with navigation accuracy [26]. In addition, age-related attenuation in functional activation in prefrontal and parahippocampal areas was accompanied by brain volume reduction [39].…”

Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 96%

“…Participants could navigate through the virtual environment with the use of keyboard, control pad, joystick, or mouse. The most frequently used virtual environment is the virtual maze, in which participants were instructed to learn and recall the topographical information to locate a target object or to find their way out of the maze [22][23][24][25][26][27]. Another frequently used virtual environment is a complex virtual town, in which participants were asked to freely navigate the environment first and later they were required to either head directly toward the goal location or follow a trail of arrows [28][29][30][31].…”

Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 99%

“…Involvement of the hippocampus has usually been implicated in allocentric representations of space that allow the computation of the direction from any start location to any goal location [29]. The parietal cortex is another brain region that has been frequently identified as being involved in spatial navigation [24,26,29,31,36] and has been implicated in providing complementary egocentric representations of locations [37]. Various brain correlates were attributed to different cognitive strategies during spatial navigation.…”

Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 99%

“…In addition to the hippocampus many other brain regions, including parahippocampal gyrus, parietal cortex, caudate nucleus, frontal cortex, posterior cingulate cortex, cerebellum, putamen, thalamus, and retrosplenial cortex, have also been identified as possible elements of a navigation system from numerous PET [29,38] and fMRI virtual reality findings [22,24,26,31,36]. For example, the parahippocampal gyrus has been implicated in allocentric representations with a different role than the hippocampus.…”

Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 99%

“…Virtual reality studies using fMRI to study age-related differences in spatial navigation have found that, compared to younger adults, older adults showed reduced activation in the hippocampus, parahippocampal gyrus, and parietal cortex [26,39,40]. For both age groups, level of activation in hippocampus and parahippocampal gyrus was positively correlated with navigation accuracy [26].…”

Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 99%

See 4 more Smart Citations

Applications of Virtual Reality Technology in Brain Imaging Studies

Chou¹,

Weingarten²,

Madden³

et al. 2012

Virtual Reality in Psychological, Medical and Pedagogical Applications

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Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 96%

Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 99%

Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 99%

Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 99%

Section: Spatial Navigation "Where Am I?" "Where Are Other Places Witmentioning

confidence: 99%

See 3 more Smart Citations

Applications of Virtual Reality Technology in Brain Imaging Studies

Chou¹,

Weingarten²,

Madden³

et al. 2012

Virtual Reality in Psychological, Medical and Pedagogical Applications

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Mobile phone exposure and spatial memory

Wiholm

Löwden

Kuster

et al. 2008

Bioelectromagnetics

Self Cite

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Radiofrequency (RF) emission during mobile phone use has been suggested to impair cognitive functions, that is, working memory. This study investigated the effects of a 2 1/2 h RF exposure (884 MHz) on spatial memory and learning, using a double-blind repeated measures design. The exposure was designed to mimic that experienced during a real-life mobile phone conversation. The design maximized the exposure to the left hemisphere. The average exposure was peak spatial specific absorption rate (psSAR10g) of 1.4 W/kg. The primary outcome measure was a "virtual" spatial navigation task modeled after the commonly used and validated Morris Water Maze. The distance traveled on each trial and the amount of improvement across trials (i.e., learning) were used as dependent variables. The participants were daily mobile phone users, with and without symptoms attributed to regular mobile phone use. Results revealed a main effect of RF exposure and a significant RF exposure by group effect on distance traveled during the trials. The symptomatic group improved their performance during RF exposure while there was no such effect in the non-symptomatic group. Until this new finding is further investigated, we can only speculate about the cause.

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Self‐reported navigation ability is associated with optic flow‐sensitive regions’ functional connectivity patterns during visual path integration

et al. 2019

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Introduction Spatial navigation is a complex cognitive skill that varies between individuals, and the mechanisms underlying this variability are not clear. Studying simpler components of spatial navigation may help illuminate factors that contribute to variation in this complex skill; path integration is one such component. Optic flow provides self‐motion information while moving through an environment and is sufficient for path integration. This study aims to investigate whether self‐reported navigation ability is related to information transfer between optic flow‐sensitive (OF‐sensitive) cortical regions and regions important to navigation during environmental spatial tasks. Methods Functional magnetic resonance imaging was used to define OF‐sensitive regions and map their functional connectivity (FC) with the retrosplenial cortex and hippocampus during visual path integration (VPI) and turn counting (TC) tasks. Both tasks presented visual self‐motion through a real‐world environment. Correlations predicting a positive association between self‐reported navigation ability (measured with the Santa Barbara Sense of Direction scale) and FC strength between OF‐sensitive regions and retrosplenial cortex and OF‐sensitive regions and the hippocampus were performed. Results During VPI, FC strength between left cingulate sulcus visual area (L CSv) and right retrosplenial cortex and L CSv and right hippocampus was positively associated with self‐reported navigation ability. FC strength between right cingulate sulcus visual area (R CSv) and right retrosplenial cortex during VPI was also positively associated with self‐reported navigation ability. These relationships were specific to VPI, and whole‐brain exploratory analyses corroborated these results. Conclusions These findings support the hypothesis that perceived spatial navigation ability is associated with communication strength between OF‐sensitive and navigationally relevant regions during visual path integration, which may represent the transformation accuracy of visual motion information into internal spatial representations. More broadly, these results illuminate underlying mechanisms that may explain some variability in spatial navigation ability.

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Age differences in the neural systems supporting human allocentric spatial navigation

Cited by 232 publications

References 34 publications

Applications of Virtual Reality Technology in Brain Imaging Studies

Applications of Virtual Reality Technology in Brain Imaging Studies

Mobile phone exposure and spatial memory

Self‐reported navigation ability is associated with optic flow‐sensitive regions’ functional connectivity patterns during visual path integration

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