Age differences in the association between sleep and Alzheimer's disease biomarkers in the EPAD cohort

Naismith, Sharon L.; Leng, Yue; Palmer, John H.; Lucey, Brendan P.

doi:10.1002/dad2.12380

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Compared to the latter, long sleep duration (≥9 h) was not significantly associated with higher Aβ burden, however it was significantly associated with worse cognitive performance in multiple domains, depressive symptoms and daytime napping (Winer et al, 2021). To investigate the age-related relationship between sleep disorders (measured by the Pittsburgh Sleep Quality Index) and AD biomarkers (CSF p-tau/Aβ42 ratio), a large group of cognitively unimpaired subjects >50 years was studied (Naismith et al, 2022). In subjects aged 50-62 years, shorter sleep duration and higher sleep efficiency were significantly associated with higher p-tau/Aβ42 ratio even when adjusted for depressive symptoms, ApOE e4 carrier status, vascular risk, hippocampal volume and WMH volume.…”

Section: Sleep and Amyloidmentioning

confidence: 99%

Associations of sleep disorders with all-cause MCI/dementia and different types of dementia – clinical evidence, potential pathomechanisms and treatment options: A narrative review

Mayer,

Frohnhofen,

Jokisch

et al. 2024

Front. Neurosci.

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Due to worldwide demographic change, the number of older persons in the population is increasing. Aging is accompanied by changes of sleep structure, deposition of beta-amyloid (Aß) and tau proteins and vascular changes and can turn into mild cognitive impairment (MCI) as well as dementia. Sleep disorders are discussed both as a risk factor for and as a consequence of MCI/dementia. Cross-sectional and longitudinal population-based as well as case–control studies revealed sleep disorders, especially sleep-disorderded breathing (SDB) and excessive or insufficient sleep durations, as risk factors for all-cause MCI/dementia. Regarding different dementia types, SDB was especially associated with vascular dementia while insomnia/insufficient sleep was related to an increased risk of Alzheimer’s disease (AD). Scarce and still inconsistent evidence suggests that therapy of sleep disorders, especially continuous positive airway pressure (CPAP) in SDB, can improve cognition in patients with sleep disorders with and without comorbid dementia and delay onset of MCI/dementia in patients with sleep disorders without previous cognitive impairment. Regarding potential pathomechanisms via which sleep disorders lead to MCI/dementia, disturbed sleep, chronic sleep deficit and SDB can impair glymphatic clearance of beta-amyloid (Aß) and tau which lead to amyloid deposition and tau aggregation resulting in changes of brain structures responsible for cognition. Orexins are discussed to modulate sleep and Aß pathology. Their diurnal fluctuation is suppressed by sleep fragmentation and the expression suppressed at the point of hippocampal atrophy, contributing to the progression of dementia. Additionally, sleep disorders can lead to an increased vascular risk profile and vascular changes such as inflammation, endothelial dysfunction and atherosclerosis which can foster neurodegenerative pathology. There is ample evidence indicating that changes of sleep structure in aging persons can lead to dementia and also evidence that therapy of sleep disorder can improve cognition. Therefore, sleep disorders should be identified and treated early.

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Section: Sleep and Amyloidmentioning

confidence: 99%

Associations of sleep disorders with all-cause MCI/dementia and different types of dementia – clinical evidence, potential pathomechanisms and treatment options: A narrative review

Mayer,

Frohnhofen,

Jokisch

et al. 2024

Front. Neurosci.

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Association Between Sleep Quantity and Quality in Early Adulthood With Cognitive Function in Midlife

Leng,

Knutson,

Carnethon

et al. 2024

Neurology

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Background and Objective Growing evidence supports an association between sleep quality and risk of dementia. However, little is known about whether objectively measured sleep duration and quality influence cognition in midlife, a period of importance for understanding the direction of the association between sleep and dementia. We examined the association between sleep duration and quality, measured when participants were in their mid-30s to late 40s, and midlife cognition assessed 11 years later among Black and White adults. Methods As part of the Coronary Artery Risk Development in Young Adults cohort study, sleep duration and quality were assessed objectively using wrist actigraphy and subjectively by Pittsburgh Sleep Quality Index (PSQI) at 2003–2005. During 2015–2016, we evaluated midlife cognition using the Digit Symbol Substitution Test (DSST), Stroop test, Rey Auditory Verbal Learning Test, Montreal Cognitive Assessment (MoCA), and Letter Fluency and Category Fluency tests. We used multivariable logistic regression to examine the association between sleep parameters and poor cognitive performance, which was defined as a score that was >1 SD below the mean score. Results The 526 participants (58% women and 44% Black) had a mean age of 40.1 ± 3.6 years at baseline, a mean sleep duration of 6.1 ± 1.1 hours, and mean sleep fragmentation index (calculated as the sum of the percentage of time spent moving and the percentage of immobile periods ≤1 minute) of 19.2 ± 8.1%, and 239 (45.6%) participants reported poor sleep as defined by a PSQI global score of >5. After adjustment for demographics, education, smoking, body mass index, depression, physical activity, hypertension, and diabetes, those in the highest vs lowest tertile of sleep fragmentation index had over twice the odds of having poor cognitive performance (>1 SD below the mean) on the DSST (odds ratio [OR] = 2.97; 95% CI 1.34–6.56), fluency (OR = 2.42; 95% CI 1.17–5.02), and MoCA test (OR = 2.29; 95% CI 1.06–4.94). The association between sleep fragmentation and cognitive performance did not differ by race or sex. Objective sleep duration or subjective sleep quality was not associated with cognition in midlife. Discussion Actigraphy-measured high sleep fragmentation rather than sleep duration was associated with worse cognition among middle-aged Black and White men and women. Sleep quality is important for cognitive health even as early as midlife.

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The Crosstalk Between Amyloid-β, Retina, and Sleep for the Early Diagnosis of Alzheimer’s Disease: A Narrative Review

De Guia,

Eslick,

Naismith

et al. 2024

ADR

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Alzheimer’s disease (AD) is the most common type of dementia, which is characterised by progressive memory loss and accumulation of hallmark markers amyloid-β (Aβ) and neurofibrillary tangles in the diseased brain. The current gold standard diagnostic methods have limitations of being invasive, costly, and not easily accessible. Thus, there is a need for new avenues, such as imaging the retina for early AD diagnosis. Sleep disruption is symptomatically frequent across preclinical and AD subjects. As circadian activity, such as the sleep-wake cycle, is linked to the retina, analysis of their association may be useful additions for achieving predictive AD diagnosis. In this narrative review, we provide an overview of human retina studies concerning the deposition of Aβ, the role of the retina in sleep-wake cycle, the disruption of sleep in AD, and to gather evidence for the associations between Aβ, the retina, and sleep. Understanding the mechanisms behind the associations between Aβ, retina, and sleep could assist in the interpretation of retinal changes accurately in AD.

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Age differences in the association between sleep and Alzheimer's disease biomarkers in the EPAD cohort

Cited by 3 publications

References 37 publications

Associations of sleep disorders with all-cause MCI/dementia and different types of dementia – clinical evidence, potential pathomechanisms and treatment options: A narrative review

Associations of sleep disorders with all-cause MCI/dementia and different types of dementia – clinical evidence, potential pathomechanisms and treatment options: A narrative review

Association Between Sleep Quantity and Quality in Early Adulthood With Cognitive Function in Midlife

The Crosstalk Between Amyloid-β, Retina, and Sleep for the Early Diagnosis of Alzheimer’s Disease: A Narrative Review

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