Age differences in fatigue, decrements in energy, and sleep disturbance in oncology patients receiving chemotherapy

Bischel, Lindsey; Ritchie, Christine S.; Kober, Kord M.; Paul, Steven M.; Cooper, Bruce A.; Chen, Lee May; Levine, Jon D.; Hammer, Marilyn J.; Wright, Fay; Miaskowski, Christine

doi:10.1016/j.ejon.2016.07.002

Cited by 20 publications

(12 citation statements)

References 52 publications

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“…[1] Fatigue negatively impacts patients’ daily activities and their quality of life (QOL). [2] While a growing body of evidence suggests that average fatigue severity is associated with a number of demographic and clinical characteristics,[3–10] these studies did not evaluate diurnal variations in fatigue severity. Recent work by our research team [11–14] and others [15–17] found that fatigue severity is extremely variable over the course of a day and among individuals.…”

Section: Introductionmentioning

confidence: 99%

Distinct evening fatigue profiles in oncology outpatients receiving chemotherapy

Wright

Cooper

Conley

et al. 2017

Fatigue: Biomedicine, Health & Behavior

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Background Fatigue is the most common and debilitating symptom experienced by oncology patients during chemotherapy (CTX). Fatigue severity demonstrates a large amount of inter-individual and diurnal variability. Purpose Study purposes were to evaluate for subgroups of patients with distinct evening fatigue profiles and evaluate how these subgroups differed on demographic, clinical, and symptom characteristics. Methods Outpatients with breast, gastrointestinal, gynecological, or lung cancer (n=1332) completed questionnaires six times over two cycles of CTX. Lee Fatigue Scale (LFS) evaluated evening fatigue severity. Latent profile analysis was used to identify distinct evening fatigue profiles. Results Four distinct evening fatigue classes (i.e., Low (14.0%), Moderate (17.2%), High (36.0%), Very High (32.8%)) were identified. Compared to the Low class, patients in the Very High evening fatigue class were: younger, female, had childcare responsibilities, had more years of education, had a lower functional status, had a higher comorbidity burden, and were diagnosed with breast cancer. Patients in the Very High class reported higher levels of depressive symptoms, sleep disturbance, and evening fatigue at enrollment. Conclusions Findings provide new insights into modifiable risk factors for higher levels of evening fatigue. Clinicians can use this information to identify higher risk patients and plan appropriate interventions.

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Section: Introductionmentioning

confidence: 99%

Distinct evening fatigue profiles in oncology outpatients receiving chemotherapy

Wright

Cooper

Conley

et al. 2017

Fatigue: Biomedicine, Health & Behavior

Self Cite

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“…The effect of chemotherapy on sleep quality has been well documented in patients with cancer (Bischel et al, ; Hong et al, ). Palesh et al () concluded that the rate of sleep disturbance was three times higher in patients receiving chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence showed that patients with cancer could have decreased sleep time and sleep efficiency (Daniel et al, 2016). In previous studies, persistent insomnia symptoms were reported to occur in as many as 22%-28% of long-term paediatric cancer survivors (Daniel et al, 2016;Zhou, Manley, Marcus, & Recklitis, 2016 The effect of chemotherapy on sleep quality has been well documented in patients with cancer (Bischel et al, 2016;Hong et al, 2014). Palesh et al (2010) concluded that the rate of sleep disturbance was three times higher in patients receiving chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…It is noteworthy that the standard chemotherapeutic agents for OS may generate many adverse short-term and long-term health impacts (Longhi, Ferrari, Bacci, & Specchia, 2007). In previous studies, sleep disturbance has been reported as a side effect of chemotherapy in patients with cancer (Bischel et al, 2016;Hong, Tian, & Wu, 2014). Specifically, paediatric cancer patients treated with chemotherapy may be more vulnerable to increased cluster of fatigue and sleep disturbance.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of sleep quality in adolescent patients with osteosarcoma using Pittsburgh Sleep Quality Index

Tao

et al. 2019

Eur J Cancer Care

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The sleep quality of patients with osteosarcoma (OS) was poorly understood. We aimed to evaluate the prevalence of sleep dysfunction in adolescent patients with OS using the Pittsburgh Sleep Quality Index (PSQI) and to further investigate the psychometric properties of the PSQI in this cohort of patients. Fifty four adolescent patients with OS who underwent chemotherapy treatment in our clinic centre were included. Sleep quality was assessed with the Chinese PSQI. Cronbach's alpha was calculated to evaluate the internal consistency. The confirmatory factor analysis (CFA) was used to determine the fitness of a two‐factor structure. Sleep disturbance was observed in 57.4% (31/54) of the patients. Patients with the presence of metastasis or more than 2 cycles of chemotherapy were found to have remarkably higher median global score. The overall Cronbach's alpha was 0.87. The CFA showed an overall comparative fit index of 0.97, a root mean square error of approximation of 0.06 and a standardised root mean square residual of 0.07 respectively. PSQI was a reliable instrument to evaluate the sleep quality of adolescent patients with OS. Over half of the patients may experience sleep disturbance during the treatment. Early psychological interventions were recommended to improve the sleep quality of the patients.

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“…Patient characteristics may also be associated with sleep disturbance in patients with cancer. Younger age has been associated with increased sleep disturbance [15,[22][23][24], although other studies have found no association between age and sleep disturbance in patients with breast cancer [1]. Additionally, a large (n=12,098) longitudinal study found that breast cancer diagnosis was not signi cantly related to decreased sleep quality compared to pre-diagnosis, although sleep quality continued to decrease over time [25].…”

Section: Introductionmentioning

confidence: 98%

Factors Associated with Sleep Disturbances in Women Undergoing Treatment for Early-Stage Breast Cancer

Grayson

Sereika

Harpel

et al. 2021

Preprint

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PurposeThe purpose of this study was to examine factors associated with sleep disturbance in women receiving adjuvant therapy for breast cancer. MethodsThis study employed a cross-sectional design using data collected at 3-months post-surgery from an ongoing longitudinal parent study. Adjuvant treatment groups included chemotherapy, radiation, aromatase inhibitor, and no adjuvant treatment. Symptoms were measured using the patient self-report measures. ResultsThe sample included 156 women diagnosed with early-stage breast cancer. There were significant differences in levels of reported sleep disturbance between treatment groups (p=0.049), with significantly higher levels of sleep disturbances in those receiving radiation compared to those receiving no adjuvant treatment (p=0.038) and in those receiving chemotherapy and those receiving no adjuvant treatment (p=0.027). Increased sleep disturbance was found to be a significant predictor for increased pain severity, nausea severity, anxiety, depressive symptoms, fatigue, decreased physical function, and decreased ability to participate in social roles and activities. Co-occurring symptoms with sleep disturbance differed between adjuvant treatment groups. Sleep disturbance was also associated with younger age (p=0.008). ConclusionsPatients undergoing chemotherapy or radiation for breast cancer report higher levels of sleep disturbance than those not receiving adjuvant therapy. Sleep disturbance is associated with other symptoms experienced by patients with cancer and thus requires continual assessment and future research into effective interventions.

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Age differences in fatigue, decrements in energy, and sleep disturbance in oncology patients receiving chemotherapy

Cited by 20 publications

References 52 publications

Distinct evening fatigue profiles in oncology outpatients receiving chemotherapy

Distinct evening fatigue profiles in oncology outpatients receiving chemotherapy

Evaluation of sleep quality in adolescent patients with osteosarcoma using Pittsburgh Sleep Quality Index

Factors Associated with Sleep Disturbances in Women Undergoing Treatment for Early-Stage Breast Cancer

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