Age-Dependent White Matter Characteristics of the Cerebellar Peduncles from Infancy Through Adolescence

Bruckert, Lisa; Shpanskaya, Katie; McKenna, Emily; Borchers, Lauren R.; Yablonski, Maya; Blecher, Tal; Ben-Shachar, Michal; Travis, Katherine E.; Feldman, Heidi M.; Yeom, Kristen W.

doi:10.1007/s12311-018-1003-9

Cited by 25 publications

(37 citation statements)

References 52 publications

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“…Of special note, cerebellar white matter consists of early-maturing tracts (41) that reach their asymptotic DTI metric values during the first decade of life, with no significant changes in FA or MD during the rest of childhood or adolescence (42, 43). In particular, DTI metrics of all three cerebellar peduncles bilaterally plateau at 70 months of age (44). Therefore, no age-related changes in the cerebellar peduncles would be expected in the range of 13–25 years of the subject groups that we studied.…”

Section: Discussionmentioning

confidence: 99%

Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion

et al. 2019

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Concussion, or mild traumatic brain injury (mTBI), is a major public health concern, linked with persistent post-concussive syndrome, and chronic traumatic encephalopathy. At present, standard clinical imaging fails to reliably detect traumatic axonal injury associated with concussion and post-concussive symptoms. Diffusion tensor imaging (DTI) is an MR imaging technique that is sensitive to changes in white matter microstructure. Prior studies using DTI did not jointly investigate white matter microstructure in athletes, a population at high risk for concussive and subconcussive head traumas, with those in typical emergency room (ER) patients. In this study, we determine DTI scalar metrics in both ER patients and scholastic athletes who suffered concussions and compared them to those in age-matched healthy controls. In the early subacute post-concussion period, athletes demonstrated an elevated rate of regional decreases in axial diffusivity (AD) compared to controls. These regional decreases of AD were especially pronounced in the cerebellar peduncles, and were more frequent in athletes compared to the ER patient sample. The group differences may indicate differences in the mechanisms of the concussive impacts as well as possible compound effects of cumulative subconcussive impacts in athletes. The prevalence of white matter abnormality in cerebellar tracts lends credence to the hypothesis that post-concussive symptoms are caused by shearing of axons within an attention network mediated by the cerebellum, and warrant further study of the correlation between cerebellar DTI findings and clinical, neurocognitive, oculomotor, and vestibular outcomes in mTBI patients.

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Section: Discussionmentioning

confidence: 99%

Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion

et al. 2019

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“…AFQ uses a three-step procedure to identify each tract in each individual: whole brain tracking, automatic segmentation using anatomically defined template Regions Of Interest (ROIs) in standard (MNI) space warped into native space, and automatic refinement and cleaning ( Yeatman et al, 2012b ). The AFQ pipeline has been successfully implemented for neonatal images in infants as young as 1 day old ( Bruckert et al, 2019b , Langer et al, 2017 ). To begin the process, the individual’s T1 weighted image is aligned with a template containing the ROIs.…”

Section: Methodsmentioning

confidence: 99%

Neonatal white matter tract microstructure and 2-year language outcomes after preterm birth

Dubner

Rose

Bruckert

et al. 2020

NeuroImage: Clinical

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“…Imaging parameters and methods for dMRI data preprocessing, analyses of subject’s motion, and individual native-space tractography have been described in several previous publications (Dodson et al, 2018; Borchers et al, 2019a; Bruckert et al, 2019) and are briefly summarized below.…”

Section: Methodsmentioning

confidence: 99%

White Matter Plasticity in Reading-Related Pathways Differs in Children Born Preterm and at Term: A Longitudinal Analysis

Bruckert

Borchers

Dodson

et al. 2019

Front. Hum. Neurosci.

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Children born preterm (PT) are at risk for white matter injuries based on complications of prematurity. They learn to read but on average perform below peers born full term (FT). Studies have yet to establish whether properties of white matter pathways at the onset of learning to read are associated with individual variation later in reading development in PT children. Here, we asked whether fractional anisotropy (FA) at age 6 years is associated with reading outcome at age 8 years in PT children in the same pathways as previously demonstrated in a sample of FT children. PT ( n = 34, mean gestational age = 29.5 weeks) and FT children ( n = 37) completed diffusion MRI and standardized measures of non-verbal IQ, language, and phonological awareness at age 6 years. Reading skills were assessed at age 8 years. Mean tract-FA was extracted from pathways that predicted reading outcome in children born FT: left arcuate fasciculus (Arc), bilateral superior longitudinal fasciculus (SLF), and left inferior cerebellar peduncle (ICP). We explored associations in additional pathways in the PT children: bilateral inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and uncinate fasciculus. Linear regression models examined whether the prediction of reading outcome at age 8 years based on mean tract-FA at age 6 years was moderated by birth group. Children born PT and FT did not differ significantly in tract-FA at age 6 years or in reading at age 8 years. Sex, socioeconomic status, and non-verbal IQ at age 6 years were associated with reading outcome and were included as covariates in all models. Birth group status significantly moderated associations between reading outcome and mean tract-FA only in the left Arc, right SLF, and left ICP, before and after consideration of pre-literacy skills. Microstructural properties of these cerebral and cerebellar pathways predicted later reading outcome in FT but not in PT children. Children born PT may rely on alternative pathways to achieve fluent reading. These findings have implications for plasticity of neural organization after early white matter injury.

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Age-Dependent White Matter Characteristics of the Cerebellar Peduncles from Infancy Through Adolescence

Cited by 25 publications

References 52 publications

Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion

Disrupted White Matter Microstructure of the Cerebellar Peduncles in Scholastic Athletes After Concussion

Neonatal white matter tract microstructure and 2-year language outcomes after preterm birth

White Matter Plasticity in Reading-Related Pathways Differs in Children Born Preterm and at Term: A Longitudinal Analysis

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