Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence

Brinksma, Djûke M; Hoekstra, Pieter J.; Hoofdakker, Barbara J. van den; Bildt, Annelies de; Buitelaar, Jan K.; Hartman, Catharina A.; Dietrich, Andrea

doi:10.1016/j.jpsychires.2017.02.014

Cited by 14 publications

(10 citation statements)

References 36 publications

(42 reference statements)

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“…Finally, this study did not account for genetic factors and genetic confounding (e.g., gene–environment correlation) cannot be ruled out. Recent evidence suggests that genetic factors may interact with exposure to pre- and perinatal risk factors for ADHD with effects decreasing over time [44]; this suggests that age may also need to be taken into account when examining risk factors. Future work on early risk factors should employ genetically informed designs, where possible, and consider the effects of age.…”

Section: Discussionmentioning

confidence: 99%

Multi-rater developmental trajectories of hyperactivity–impulsivity and inattention symptoms from 1.5 to 17 years: a population-based birth cohort study

Vergunst

Tremblay

Galèra

et al. 2018

Eur Child Adolesc Psychiatry

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The developmental course of hyperactivity–impulsivity and inattention symptoms from infancy to adolescence has not been documented in a population sample. The aim of this study was to describe the developmental course of hyperactivity–impulsivity and inattention symptoms from 1.5 to 17 years using multiple informants, and to identify perinatal risk factors associated with following elevated (high-risk) trajectories. Using a population-based birth cohort ( n = 1374), symptom ratings from mothers (1.5–8 years), teachers (6–13 years) and participant self-reports (10–17 years) were combined using group-based multi-trajectory modeling to identify informants’ convergence in identifying high-symptom trajectories of hyperactivity–impulsivity and inattention over time. Perinatal risk factors associated with high-symptom trajectories were identified using stepwise logistic regression. The study found that symptoms of hyperactivity–impulsivity broadly declined from 1.5 to 17 years while symptoms of inattention remained constant. 21.4% of participants followed elevated trajectories of hyperactivity–impulsivity and 20.2% followed elevated trajectories of inattention; 11.6% followed elevated trajectories of both types of symptoms concurrently. Risk factors for high-risk trajectories of hyperactivity–impulsivity were low maternal education, prenatal alcohol exposure, non-intact family, maternal depression, and low child IQ; for high-risk inattention they were prenatal street drug exposure, early motherhood, low maternal education, maternal depression and low child IQ. Risk factors for trajectories of high-risk hyperactivity–impulsivity and inattention concurrently were low maternal education, maternal depression, and low child IQ. The combination of longitudinal assessments from multiple informants (i.e., mother, teacher, participant-reports) provides a new way to characterize hyperactivity–impulsivity and inattention phenotypes over time. Electronic supplementary material The online version of this article (10.1007/s00787-018-1258-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Multi-rater developmental trajectories of hyperactivity–impulsivity and inattention symptoms from 1.5 to 17 years: a population-based birth cohort study

Vergunst

Tremblay

Galèra

et al. 2018

Eur Child Adolesc Psychiatry

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“…Notably, consistent with our findings, Kistner-Griffin et al (2011) only found an association between offspring 5-HTTLPR genotype and ASD diagnosis in the Non-European ancestry cohort but not in the European ancestry cohort. While we controlled for multiple potentially mediating factors, we cannot preclude the influence of other potential factors such as prenatal stress (Hecht et al, 2016) and pregnancy and delivery complications (Brinksma et al, 2017). Inconsistent with earlier findings, maternal expressed emotion was similar between the two maternal genotype groups (Bakermans-Kranenburg and van Ijzendoorn, 2008;Cents et al, 2014;Mileva-Seitz et al, 2011;Morgan et al, 2018).…”

Section: Discussionmentioning

confidence: 50%

Maternal serotonin transporter genotype and offsprings' clinical and cognitive measures of ADHD and ASD

Hanswijk

Rooij

Oosterlaan

et al. 2021

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Individual differences in these early developing cognitive domains may be partially responsible for the long‐term effects of prenatal conditions on children's higher order cognitive functioning. Indeed, many studies document deficits in general cognitive capacities (e.g., mental development scores, attention) for children born preterm and/or low birth weight (Murray et al., ), and among children exposed to high levels of prenatal maternal stress (Huizink, Robles de Medina, Mulder, Visser, & Buitelaar, ) and obstetric complications (Brinksma et al., ).…”

Section: Prenatal Programming Of Efmentioning

confidence: 99%

Prenatal Risk Predicts Preschooler Executive Function: A Cascade Model

Camerota

Willoughby

2019

Child Development

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Little research has considered whether prenatal experience contributes to executive function (EF) development above and beyond postnatal experience. This study tests direct, mediated, and moderated associations between prenatal risk factors and preschool EF and IQ in a longitudinal sample of 1,292 children from the Family Life Project. A composite of prenatal risk factors (i.e., low birth weight, prematurity, maternal emotional problems, maternal prepregnancy obesity, and obstetric complications) significantly predicted EF and IQ at age 3, above quality of the postnatal environment. This relationship was indirect, mediated through infant general cognitive abilities. Quality of the postnatal home and child-care environments did not moderate the cascade model. These findings highlight the role of prenatal experience as a contributor to individual differences in cognitive development.

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Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence

Cited by 14 publications

References 36 publications

Multi-rater developmental trajectories of hyperactivity–impulsivity and inattention symptoms from 1.5 to 17 years: a population-based birth cohort study

Multi-rater developmental trajectories of hyperactivity–impulsivity and inattention symptoms from 1.5 to 17 years: a population-based birth cohort study

Maternal serotonin transporter genotype and offsprings' clinical and cognitive measures of ADHD and ASD

Prenatal Risk Predicts Preschooler Executive Function: A Cascade Model

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